Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Clara K. Schindler"'
Autor:
David C. Henshall, Shana L. Skradski, Robert Meller, Tomohiro Araki, Manabu Minami, Clara K. Schindler, Jing-Quan Lan, David P. Bonislawski, Roger P. Simon
Publikováno v:
Neurobiology of Disease, Vol 10, Iss 2, Pp 71-87 (2002)
The caspase family of cell death proteases has been implicated in the mechanism of neuronal death following seizures. We investigated the expression and processing of caspases 6 and 7, putative executioner caspases. Brief limbic seizures were evoked
Externí odkaz:
https://doaj.org/article/1c6ba07d93bf4282acc9572331c39fc0
Autor:
David C. Henshall, Nikolaus Plesnila, Tobias Engel, Clara K. Schindler, Jochen H. M. Prehn, Aurelien Caballero-Caballero, Andreas Strasser
Publikováno v:
Journal of Neurochemistry. 115:92-101
Prolonged seizures activate members of the Bcl-2 homology domain 3-only sub-group of the Bcl-2 protein family, which are essential for initiation of apoptosis signaling. Bid is a potent pro-apoptotic Bcl-2 homology domain 3-only protein, which upon p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61b340c5c5d54c9b10067d86449e2df6
https://doi.org/10.1111/j.1471-4159.2010.06909.x
https://doi.org/10.1111/j.1471-4159.2010.06909.x
Autor:
Mark Dunleavy, Claire Ewart, Christian Kerskens, Ross D. Dolan, David C. Henshall, Clara K. Schindler, Sachiko Shinoda, Oliviero L. Gobbo
Publikováno v:
The American Journal of Pathology. 176:330-342
Hippocampal sclerosis is a common pathological finding in patients with temporal lobe epilepsy, including children, but a causal relationship to early-life seizures remains in question. Neonatal status epilepticus in animals can result in neuronal de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bef22e25038e69189a70d3293f5d02e
https://doi.org/10.2353/ajpath.2010.090119
https://doi.org/10.2353/ajpath.2010.090119
Autor:
Robert Meller, Clara K. Schindler, Akitaka Yamamoto, Roger P. Simon, Brona M. Murphy, Carmen Bellver-Estelles, Waro Taki, Norman K. So, David C. Henshall
Publikováno v:
Experimental Neurology. 202:410-420
Seizures, particularly when prolonged, may cause neuronal loss within vulnerable brain structures such as the hippocampus, in part by activating programmed (apoptotic) cell death pathways. Experimental modeling suggests that seizures activate tumor n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541d3c1316d9fee3d44d892270eddbc2
https://doi.org/10.1016/j.expneurol.2006.07.003
https://doi.org/10.1016/j.expneurol.2006.07.003
Autor:
Manabu Minami, Julie A. Saugstad, Corrin Erin Clayton, Jennifer A. Cameron, Andrea Nicole Ordonez, Robert Meller, Clara K. Schindler, David C. Henshall, Daniel John Torrey, Roger P. Simon
Publikováno v:
Journal of Biological Chemistry. 281:7429-7436
A previous exposure to a non-harmful ischemic insult (preconditioning) protects the brain against subsequent harmful ischemia (ischemic tolerance). In contrast to delayed gene-mediated ischemic tolerance, little is known about the molecular mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda979574e9c9370ecd1cc55d565b9a0
https://doi.org/10.1074/jbc.m512138200
https://doi.org/10.1074/jbc.m512138200
Autor:
Clara K. Schindler, David C. Henshall, Jochen H. M. Prehn, Roger P. Simon, Erik G. Pearson, Norman K. So, Helena P. Bonner
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 26:583-589
Programmed cell death (apoptosis) signaling pathways have been implicated in seizure-induced neuronal death and the pathogenesis of human temporal lobe epilepsy (TLE). End-stage DNA fragmentation during cell death may be mediated by nucleases includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d342e93f73a54bef95bab0a8f385ca
https://doi.org/10.1038/sj.jcbfm.9600219
https://doi.org/10.1038/sj.jcbfm.9600219
Autor:
Waro Taki, Clara K. Schindler, Roger P. Simon, Sachiko Shinoda, Tomohiro Araki, Jing-Quan Lan, David C. Henshall
Publikováno v:
Journal of Neuroscience Research. 76:121-128
Although mice are amenable to gene knockout, they have not been exploited in the setting of seizure-induced neurodegeneration due to the resistance to injury of key mouse strains. We refined and developed models of seizure-induced neuronal death in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58823cfd15395dcaaa499557ab77d6f7
https://doi.org/10.1002/jnr.20064
https://doi.org/10.1002/jnr.20064
Autor:
Sachiko Shinoda, Waro Taki, Roger P. Simon, Clara K. Schindler, David C. Henshall, Julie A. Saugstad, Jing Quan-Lan
Publikováno v:
Journal of Neurochemistry. 86:460-469
Seizure-induced neuronal death may involve coordinated intracellular trafficking and protein–protein interactions of members of the Bcl-2 family. The 14-3-3 proteins are known to sequester certain pro-apoptotic members of this family. BH3-interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0e2b5219241199c3821de8de3bf6cf0
https://doi.org/10.1046/j.1471-4159.2003.01860.x
https://doi.org/10.1046/j.1471-4159.2003.01860.x
Autor:
Clara K. Schindler, Roger P. Simon, Sachiko Shinoda, David C. Henshall, Tomohiro Araki, Jing-Quan Lan
Publikováno v:
Journal of Neurochemistry. 86:1260-1270
Death-associated protein (DAP) kinase is calcium-regulated and known to function downstream of death receptors, prompting us to examine its role in the mechanism of seizure-induced neuronal death. Brief seizures were focally evoked in rats, eliciting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1da99837456685845574d7ee8be0f698
https://doi.org/10.1046/j.1471-4159.2003.01934.x
https://doi.org/10.1046/j.1471-4159.2003.01934.x
Autor:
Jing-Quan Lan, Robert Meller, Clara K. Schindler, Roger P. Simon, David C. Henshall, Sachiko Shinoda, Tomohiro Araki, Shana L. Skradski, Waro Taki
Publikováno v:
European Journal of Neuroscience. 17:2065-2076
The consequences of activation of tumour necrosis factor receptor 1 (TNFR1) during neuronal injury remain controversial. The apoptosis signal-regulating kinase 1 (ASK1), a mitogen-activated protein kinase kinase kinase, can mediate cell death downstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e24591f619b42485902ac0e585a6ec8
https://doi.org/10.1046/j.1460-9568.2003.02655.x
https://doi.org/10.1046/j.1460-9568.2003.02655.x