Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Clara Herrera Arozamena"'
Autor:
Martín Estrada-Valencia, Clara Herrera-Arozamena, Concepción Pérez, Dolores Viña, José A. Morales-García, Ana Pérez-Castillo, Eva Ramos, Alejandro Romero, Erik Laurini, Sabrina Pricl, María Isabel Rodríguez-Franco
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 712-727 (2019)
The design of multi-target directed ligands (MTDLs) is a valid approach for obtaining effective drugs for complex pathologies. MTDLs that combine neuro-repair properties and block the first steps of neurotoxic cascades could be the so long wanted rem
Externí odkaz:
https://doaj.org/article/ed3ffb901f804e3298167947f93fccbc
Autor:
Clara Herrera-Arozamena, Martín Estrada-Valencia, Patricia López-Caballero, Concepción Pérez, José A. Morales-García, Ana Pérez-Castillo, Eric del Sastre, Cristina Fernández-Mendívil, Pablo Duarte, Patrycja Michalska, José Lombardía, Sergio Senar, Rafael León, Manuela G. López, María Isabel Rodríguez-Franco
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
By replacing a phenolic ring of (E)-resveratrol with an 1,3,4-oxadiazol-2(3H)-one heterocycle, new resveratrol-based multi- target-directed ligands (MTDLs) were obtained. They were evaluated in several assays related to oxidative stress and inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba29a16c8d4c68e2a43e88dfcdc7e35c
http://hdl.handle.net/10261/270182
http://hdl.handle.net/10261/270182
Autor:
Clara Herrera-Arozamena, Olaia Martí-Marí, Martín Estrada, Mario de la Fuente Revenga, María Isabel Rodríguez-Franco
Publikováno v:
Molecules, Vol 21, Iss 9, p 1165 (2016)
The central nervous system of adult mammals has long been considered as a complex static structure unable to undergo any regenerative process to refurbish its dead nodes. This dogma was challenged by Altman in the 1960s and neuron self-renewal has be
Externí odkaz:
https://doaj.org/article/af766d37339b41eea17929d2cb7aa877
Autor:
Dolores Viña, Erik Laurini, Concepción Pérez, José A. Morales-García, Eva Ramos, Sabrina Pricl, María Isabel Rodríguez-Franco, Ana Perez-Castillo, Clara Herrera-Arozamena, Alejandro Romero, Martín Estrada-Valencia
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 712-727 (2019)
Journal of Enzyme Inhibition and Medicinal Chemistry
Digital.CSIC. Repositorio Institucional del CSIC
instname
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Journal of Enzyme Inhibition and Medicinal Chemistry
Digital.CSIC. Repositorio Institucional del CSIC
instname
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
The design of multi-target directed ligands (MTDLs) is a valid approach for obtaining effective drugs for complex pathologies. MTDLs that combine neuro-repair properties and block the first steps of neurotoxic cascades could be the so long wanted rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2268ce68b4d3f496cbf99e667b2ec2a1
https://doaj.org/article/ed3ffb901f804e3298167947f93fccbc
https://doaj.org/article/ed3ffb901f804e3298167947f93fccbc
Autor:
Lucía Viejo, María Isabel Rodríguez-Franco, Elies Molins, Daniel J. V. A. dos Santos, Lídia Gonçalves, Maria M. M. Santos, Clara Herrera-Arozamena, Cristóbal de los Ríos, Margarida Espadinha, Ricardo M R M Lopes
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
N-Methyl-D-aspartate receptors (NMDARs) are crucial for the normal function of the central nervous system (CNS), and fundamental in memory and learning-related processes. The overactivation of these receptors is associated with numerous neurodegenera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a397ed2a33305f849048690268adb758
http://hdl.handle.net/10261/219127
http://hdl.handle.net/10261/219127
Autor:
Concepción Pérez, Clara Herrera-Arozamena, Olaia Martí-Marí, María Isabel Rodríguez-Franco, Mario de la Fuente Revenga, Carlos A. Villalba-Galea, Martín Estrada-Valencia
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
By linking two N-methyl-N-carbocyclic quaternary ammonium groups to an azobenzene scaffold in meta- or para-positions we generated a series of photoswitchable neuromuscular ligands for which we coined the term “azocuroniums”. These compounds swit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf3cdf80ed4edae8f488ee4d249b1d8
http://hdl.handle.net/10261/217685
http://hdl.handle.net/10261/217685
Autor:
Ana Perez-Castillo, Laura Lagartera, Raquel Fernández-Ginés, Rafael León, María Isabel Rodríguez-Franco, Clara Herrera-Arozamena, Martín Estrada-Valencia, Ángel Juan García-Yagüe, Alberto Mills, Juan Felipe Franco-Gonzalez, Concepción Pérez, Manuela G. López, José A. Morales-García, Pablo Daniel Palacios Duarte, Patrycja Michalska, Antonio Cuadrado, Federico Gago
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
New multi-target indole and naphthalene derivatives containing the oxadiazolone scaffold as a bioisostere of the melatonin acetamido group have been developed. The novel compounds were characterized at melatonin receptors MT1R and MT2R, quinone reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9734c3a96d31d970da006c9946324156
http://hdl.handle.net/10261/219073
http://hdl.handle.net/10261/219073
Autor:
María Isabel Rodríguez-Franco, Carlos A. Villalba-Galea, Martín Estrada-Valencia, Clara Herrera-Arozamena
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Muscular nicotinic acetylcholine receptors (nAChR) are ligand-gated ion channels located in the plasma membrane of the post-junctional motor endplate in skeletal muscles. These receptors are responsible for triggering the electrical signal that leads
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98dfb50af3cdf1218f5e4035420191bd
http://hdl.handle.net/10261/206136
http://hdl.handle.net/10261/206136
Autor:
Daniel J. V. A. dos Santos, María Isabel Rodríguez-Franco, Lídia Gonçalves, Cristóbal de los Ríos, Clara Herrera Arozamena, Margarida Espadinha, João Lopes, Rocío Lajarín-Cuesta, Maria M. M. Santos, Jorge Dourado
Publikováno v:
Proceedings of 4th International Electronic Conference on Medicinal Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c92197f6b2944b7e50f12b91ed749236
https://doi.org/10.3390/ecmc-4-05631
https://doi.org/10.3390/ecmc-4-05631
Autor:
Dolores Viña, Concepción Pérez, Martín Estrada Valencia, Matilde Yáñez, Ana Perez-Castillo, Eva Ramos, Lucía de Andrés, Alejandro Romero, Erik Laurini, José A. Morales-García, Clara Herrera-Arozamena, Sabrina Pricl, María Isabel Rodríguez-Franco
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
In this work we describe neurogenic and neuroprotective donepezil-flavonoid hybrids (DFHs), exhibiting nanomolar affinities for the sigma-1 receptor and inhibition of key enzymes in Alzheimer's disease (AD), such as acetylcholinesterase (AChE), 5-lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247b8a43e5057075006e40205c4adf67
https://www.sciencedirect.com/science/article/pii/S0223523418305828
https://www.sciencedirect.com/science/article/pii/S0223523418305828