Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Clara H. Eng"'
Autor:
Kimberly Kanada, Vishakha Gupta, Vivek T. Natarajan, David H. Way, Susan Huang, Sara Gabriele, Clara H. Eng, Rainer Hofmann-Wellenhof, Dale R. Webster, R. Carter Dunn, Kang Lee, David Coz, Lily Peng, Jessica Gallegos, Greg S. Corrado, Peggy Bui, Guilherme de Oliveira Marinho, Nalini Singh, Dennis Ai, Yuan Liu, Ayush Jain, Yun Liu
Publikováno v:
Nature Medicine. 26:900-908
Skin conditions affect an estimated 1.9 billion people worldwide. A shortage of dermatologists causes long wait times and leads patients to seek dermatologic care from general practitioners. However, the diagnostic accuracy of general practitioners h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03adba782c6fdb46b6d99afb234fc18
https://doi.org/10.1038/s41591-020-0842-3
https://doi.org/10.1038/s41591-020-0842-3
Autor:
Vishakha Gupta, Rory Sayres, Ayush Jain, David H. Way, Lily Peng, Yun Liu, Karen DeSalvo, Jay David Hartford, Yuan Liu, Peggy Bui, Clara H. Eng, Greg S. Corrado, Carter Dunn, Dale R. Webster, David Coz, Guilherme de Oliveira Marinho, Yi Gao, Susan Jen Huang, Kunal Nagpal, Kimberly Kanada
Publikováno v:
JAMA Netw Open
IMPORTANCE: Most dermatologic cases are initially evaluated by nondermatologists such as primary care physicians (PCPs) or nurse practitioners (NPs). OBJECTIVE: To evaluate an artificial intelligence (AI)–based tool that assists with diagnoses of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f15f4d01a80bdb2ad88ec9daa2f4c6eb
https://europepmc.org/articles/PMC8082316/
https://europepmc.org/articles/PMC8082316/
Publikováno v:
British Journal of Dermatology. 182:1277-1278
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32bed5f0cd47f57c8fa283fd448b9b65
https://doi.org/10.1111/bjd.18609
https://doi.org/10.1111/bjd.18609
Autor:
Clara H. Eng, Jay D. Keasling, Edward E. K. Baidoo, George Wang, Leonard Katz, Satoshi Yuzawa
Publikováno v:
Biochemistry. 55:1677-1680
Polyketide natural products have broad applications in medicine. Exploiting the modular nature of polyketide synthases to alter stereospecificity is an attractive strategy for obtaining natural product analogues with altered pharmaceutical properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b461176db235309f2349c97ed8861095
https://doi.org/10.1021/acs.biochem.6b00129
https://doi.org/10.1021/acs.biochem.6b00129
Autor:
Jay D. Keasling, Leonard Katz, Pierre Baldi, Christophe Magnan, Clara H. Eng, Tyler W. H. Backman, Constance B. Bailey, Hector Garcia Martin
Publikováno v:
Nucleic acids research, vol 46, iss D1
Nucleic Acids Research
Eng, C H, Backman, T W H, Bailey, C B, Magnan, C, Martin, H G, Katz, L, Baldi, P & Keasling, J D 2018, ' ClusterCAD: a computational platform for type I modular polyketide synthase design ', Nucleic Acids Research, vol. 46, no. D1, pp. D509-D515 . https://doi.org/10.1093/nar/gkx893
Nucleic Acids Research
Eng, C H, Backman, T W H, Bailey, C B, Magnan, C, Martin, H G, Katz, L, Baldi, P & Keasling, J D 2018, ' ClusterCAD: a computational platform for type I modular polyketide synthase design ', Nucleic Acids Research, vol. 46, no. D1, pp. D509-D515 . https://doi.org/10.1093/nar/gkx893
ClusterCAD is a web-based toolkit designed to leverage the collinear structure and deterministic logic of type I modular polyketide synthases (PKSs) for synthetic biology applications. The unique organization of these megasynthases, combined with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec6b91b3cf5e97872633b17c7c1b106
https://escholarship.org/uc/item/7h84g10b
https://escholarship.org/uc/item/7h84g10b
At the extreme energies of the Large Hadron Collider, massive particles can be produced at such high velocities that their hadronic decays are collimated and the resulting jets overlap. Deducing whether the substructure of an observed jet is due to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a16f290005bb437e94c635431ad53d3
Publikováno v:
The Journal of Antibiotics. 67:199-201
Enzyme analysis of the polyketide synthase leads to the discovery of a novel analog of the antibiotic α-lipomycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017c4125fc8c55c332ca85a9c99d4784
https://doi.org/10.1038/ja.2013.110
https://doi.org/10.1038/ja.2013.110
Publikováno v:
Biochemistry. 52:3791-3793
LipPks1, a polyketide synthase subunit of the lipomycin synthase, is believed to catalyze the polyketide chain initiation reaction using isobutyryl-CoA as a substrate, followed by an elongation reaction with methylmalonyl-CoA to start the biosynthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07608a03d749b4c072a1d277fbfd81e4
https://doi.org/10.1021/bi400520t
https://doi.org/10.1021/bi400520t