A modelling study highlights the power of detecting and isolating asymptomatic or very mildly affected individuals for COVID-19 epidemic management

Autor: Lía Mayorga, Clara García Samartino, Gabriel Flores, Sofía Masuelli, María V. Sánchez, Luis S. Mayorga, Cristián G. Sánchez

Publikováno v: BMC Public Health, Vol 20, Iss 1, Pp 1-11 (2020)

Abstract Background Mathematical modelling of infectious diseases is a powerful tool for the design of management policies and a fundamental part of the arsenal currently deployed to deal with the COVID-19 pandemic. Methods We present a compartmental

Externí odkaz: https://doaj.org/article/8bc94703fc724b328db9d4713e243d15

An oral vaccine based on U-Omp19 induces protection against B. abortus mucosal challenge by inducing an adaptive IL-17 immune response in mice.

Autor: Karina A Pasquevich, Andrés E Ibañez, Lorena M Coria, Clara García Samartino, Silvia M Estein, Astrid Zwerdling, Paula Barrionuevo, Fernanda S Oliveira, Christine Seither, Heribert Warzecha, Sergio C Oliveira, Guillermo H Giambartolomei, Juliana Cassataro

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e16203 (2011)

As Brucella infections occur mainly through mucosal surfaces, the development of mucosal administered vaccines could be radical for the control of brucellosis. In this work we evaluated the potential of Brucella abortus 19 kDa outer membrane protein

Externí odkaz: https://doaj.org/article/e8f429a7dee847bab0e60347215e54b4

A modelling study highlights the power of detecting and isolating asymptomatic or very mildly affected individuals for COVID-19 epidemic management

Autor: Clara García Samartino, Lía Mayorga, Maria Victoria Sanchez, Luis S. Mayorga, Cristián G. Sánchez, Gabriel Flores, Sofía Masuelli

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
BMC Public Health, Vol 20, Iss 1, Pp 1-11 (2020)
BMC Public Health

Background: Mathematical modelling of infectious diseases is a powerful tool for the design of management policies and a fundamental part of the arsenal currently deployed to deal with the COVID-19 pandemic. Methods: We present a compartmental model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77d277a7c817d98667837d4109e955f
https://doi.org/10.1186/s12889-020-09843-7

Mitochondrial stress triggers a pro-survival response through epigenetic modifications of nuclear DNA

Autor: María Roqué, Hernán Eiroa, Clara García Samartino, Patricia Silvia Romano, Lía Mayorga, Diego M. Marzese, Betiana Nebaí Salassa, Mariana Loos, Fabiana Lubieniecki

Publikováno v: Cellular and molecular life sciences : CMLS. 76(7)

Mitochondrial dysfunction represents an important cellular stressor and when intense and persistent cells must unleash an adaptive response to prevent their extinction. Furthermore, mitochondria can induce nuclear transcriptional changes and DNA meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d986a332886a10d2bfb675fb6707ae7b
https://pubmed.ncbi.nlm.nih.gov/30673822

Brucella abortusInhibits Major Histocompatibility Complex Class II Expression and Antigen Processing through Interleukin-6 Secretion via Toll-Like Receptor 2

Autor: Carlos A. Fossati, M. Victoria Delpino, Paula Barrionuevo, Jorge C. Wallach, Clara García Samartino, Juliana Cassataro, Astrid Zwerdling, Guillermo H. Giambartolomei, Karina A. Pasquevich

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The strategies that allow Brucella abortus to survive inside macrophages for prolonged periods and to avoid the immunological surveillance of major histocompatibility complex class II (MHC-II)-restricted gamma interferon (IFN-γ)-producing CD4+ T lym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2ef3b8e1de291e0cc3e1840596519a
https://doi.org/10.1128/iai.00949-07