Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Clara Dees"'
Autor:
Ariella Zehender, Jingang Huang, Andrea-Hermina Györfi, Alexandru-Emil Matei, Thuong Trinh-Minh, Xiaohan Xu, Yi-Nan Li, Chih-Wei Chen, Jianping Lin, Clara Dees, Christian Beyer, Kolja Gelse, Zhong-Yin Zhang, Christina Bergmann, Andreas Ramming, Walter Birchmeier, Oliver Distler, Georg Schett, Jörg H. W. Distler
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Hyperactivation of TGFβ signaling is a common feature of fibrotic diseases. Here the authors show that genetic or pharmacologic inactivation of the tyrosine phosphatase SHP2 prevents TGFβ-induced JAK2/STAT3 signaling, inhibits fibroblast activation
Externí odkaz:
https://doaj.org/article/ca9d656a05724b31bfb9bc55df9634bf
Autor:
Julia Winkler, Andreas Mackensen, Jörg H W Distler, Clara Dees, Xianyi Meng, Andreas Beilhack, Wolfgang Herr, Honglin Zhu, Cuong Tran-Manh, Thuong Trinh-Minh, Katja Dreißigacker, Mirjana Ziemer, Yun Zhang, Bernd M. Spriewald, Chih-Wei Chen, Alexandru-Emil Matei, Sigrid Karrer, Daniel Wolff, Georg Schett, Lichong Shen, Markus Ditschkowski, Stefan Krauss
Publikováno v:
Blood. 137:2403-2416
Chronic graft-versus-host disease (cGVHD) is a major life-threatening complication of allogeneic hematopoietic stem cell transplantation. The molecular mechanisms underlying cGVHD remain poorly understood, and targeted therapies for clinical use are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a60a1e95fd9c059d23e4af1f24e9b75
https://doi.org/10.1182/blood.2020008720
https://doi.org/10.1182/blood.2020008720
Autor:
Philipp Ritt, Christoph Treutlein, Christina Bergmann, Andreas Ramming, Markus Köhner, Olaf Prante, Tobias Bäuerle, Alina Soare, Torsten Kuwert, Clara Dees, Jörg H W Distler, Michael Cordes, Theresa Ida Götz, Anna-Theresa Müller, Armin Atzinger, Verena Schönau, Oliver Distler, Christian Schmidkonz, Koray Tascilar, Johannes Knitza, Andrea-Hermina Györfi, Georg Schett, Anja Lück, Alexandru-Emil Matei
Publikováno v:
The Lancet Rheumatology. 3:e185-e194
Summary Background Interstitial lung disease (ILD) is the most common cause of death in systemic sclerosis. To date, the progression of systemic sclerosis-associated ILD is judged by the accrual of lung damage on CT and pulmonary function tests. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28e361d61a3ec6ad12acd7889f6b6801
https://doi.org/10.1016/s2665-9913(20)30421-5
https://doi.org/10.1016/s2665-9913(20)30421-5
Publikováno v:
Experimental Dermatology. 30:121-131
The activation of fibroblasts is required for physiological tissue remodelling such as wound healing. However, when the regulatory mechanisms are disrupted and fibroblasts remain persistently activated, the progressive deposition of extracellular mat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0749d590ac4dd496a9ec6339f04a6e76
https://doi.org/10.1111/exd.14193
https://doi.org/10.1111/exd.14193
Autor:
Clara Dees, Philip Janiak, Bertrand Léger, Christian Beyer, Alfiya Distler, Josef Pernerstorfer, Jean Pierre Bidouard, Laetitia Ledein, Serena Vettori, Stephane Illiano, Rachid Boukaiba, Jörg H W Distler, Oliver Distler, Matthias Schaefer, Hartmut Ruetten, Alexandre Jagerschmidt
Publikováno v:
British Journal of Pharmacology
Background and purpose Genetic deletion and pharmacological studies suggest a role for lysophosphatidic acid (LPA1 ) receptor in fibrosis. We investigated the therapeutic potential in systemic sclerosis (SSc) of a new orally active selective LPA1 rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3461709fb9e09a11345ee3c0c728b42c
https://doi.org/10.1111/bph.15190
https://doi.org/10.1111/bph.15190
Autor:
Raymund E. Horch, Ingo Ludolph, A. E. Matei, Jörg H W Distler, Alina Soare, Georg Schett, Carina Mihai, Andreas Ramming, Hermina A. Györfi, Simon Rauber, Thomas Wohlfahrt, Stephan von Hörsten, Chih-Wei Chen, Tobias Bäuerle, Clara Dees, Oliver Distler
Publikováno v:
Arthritis & Rheumatology. 72:137-149
OBJECTIVE Expression of dipeptidylpeptidase 4 (DPP-4) identifies a dermal fibroblast lineage involved in scarring during wound healing. The role of DDP-4 in tissue fibrosis is, however, unknown. The aim of the present study was to evaluate DPP-4 as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::423dcfe4121ce33759f308751b8b6255
https://doi.org/10.1002/art.41058
https://doi.org/10.1002/art.41058
Autor:
Michael Stürzl, Christian Beyer, Christiane Maier, Simon Rauber, Andreas Ramming, Falk Butter, Astrid Jüngel, Arif B. Ekici, Jörg H W Distler, Clara Dees, Steffen Uebe, Christoph Daniel, Stephen L. Nutt, Stefanie Weber, Michael Sticherling, Hans P. Kiener, Kolja Gelse, Georg Schett, Emmanuel Karouzakis, Susetta Finotto, E. Pachera, David W. Boykin, Alexandru-Emil Matei, Mark H. Kaplan, Andreas E. Kremer, Alina Soare, Elisabeth Naschberger, Oliver Distler, Gregory M.K. Poon, Markus Luber, Chih-Wei Chen, Alexander Kreuter, Thomas Wohlfahrt
Publikováno v:
Nature
Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue homeostasis and immune responses. In fibrotic diseases, fibroblasts synthesize abundant amounts of extracellular matrix, which induces scarring and organ failure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3525228a2dbf2fe6b17117fd7441a0
https://doi.org/10.1038/s41586-019-0896-x
https://doi.org/10.1038/s41586-019-0896-x
Autor:
Chih-Wei Chen, Mirjana Ziemer, Christina Bergmann, Ariella Zehender, Jörg H W Distler, Alexander Kreuter, Xiang Zhou, Annemarie Schwab, Andrea Hermina Györfi, Sara Chenguiti Fakhouri, A. Brandt, Aline Bozec, L. Hallenberger, Clara Dees, Roland Coras, Debomita Chakraborty, B. Merlevede, Honglin Zhu, Georg Schett, Thuong Trinh-Minh, Simon Rauber, Alexandru-Emil Matei
Publikováno v:
Annals of the rheumatic diseases. 80(8)
ObjectiveX-linked inhibitor of apoptosis protein (XIAP) is a multifunctional protein with important functions in apoptosis, cellular differentiation and cytoskeletal organisation and is emerging as potential target for the treatment of various cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf28e903b0eac2c7b1ad7537768c235
https://pubmed.ncbi.nlm.nih.gov/33903093
https://pubmed.ncbi.nlm.nih.gov/33903093
Autor:
Bertram Bengsch, Raymund E. Horch, Meik Kunz, Markus Luber, Georg Schett, Maximilian Fuchs, Alexandru-Emil Matei, Aleix Rius Rigau, Xuezhi Hong, Ingo Ludolph, Jörg H W Distler, Christina Bergmann, Chunguang Liang, Oliver Distler, Honglin Zhu, Clara Dees, Andrea-Hermina Györfi, Jiucun Wang
Publikováno v:
The Journal of experimental medicine. 218(9)
Transforming growth factor-β (TGFβ) is a key mediator of fibroblast activation in fibrotic diseases, including systemic sclerosis. Here we show that Engrailed 1 (EN1) is reexpressed in multiple fibroblast subpopulations in the skin of SSc patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c675c4f1184cd2f2e4102646a543b073
https://pubmed.ncbi.nlm.nih.gov/34259830
https://pubmed.ncbi.nlm.nih.gov/34259830
Autor:
Diana Distler, Andrea Hermina Györfi, Ingo Ludolph, Yun Zhang, Jörg H W Distler, Katja Dreissigacker, Thuong Trinh-Minh, Xiang Zhou, Xianyi Meng, Clara Dees, Andreas Ramming, Raymund E. Horch, Lichong Shen, Honglin Zhu, Christina Bergmann, Georg Schett
Publikováno v:
Annals of the rheumatic diseases. 79(9)
ObjectivesCoactivators are a heterogeneous family of transcriptional regulators that are essential for modulation of transcriptional outcomes and fine-tune numerous cellular processes. The aim of the present study was to evaluate the role of the coac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5ea4929cee2319b3e741c7a22dadfb
https://pubmed.ncbi.nlm.nih.gov/32482644
https://pubmed.ncbi.nlm.nih.gov/32482644