Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Clara Bovino"'
Autor:
Matt Timmers, Andi Kipper, Raphael Frey, Stef Notermans, Maksym Voievudskyi, Claire Wilson, Nina Hentzen, Michael Ringle, Clara Bovino, Bernhard Stump, Cristianne J. F. Rijcken, Tina Vermonden, Ingrid Dijkgraaf, Rob Liskamp
Publikováno v:
Pharmaceuticals, Vol 16, Iss 8, p 1155 (2023)
The recently developed compound, tetramethylthiocycloheptyne sulfoximine (TMTHSI), has shown to be a promising strained alkyne for strain-promoted azide–alkyne cycloaddition (SPAAC), metal-free click chemistry. This research explores the properties
Externí odkaz:
https://doaj.org/article/9da70c47b33e40b898bbaddea38432fe
Autor:
Ornella Letari, Benedetta Buzzi, Paolo Garofalo, Luigi Piero Stasi, Luca Canciani, Gianfranco Caselli, Fabrizio Colace, Roberto Artusi, Matteo Salvi, Clara Bovino, Patrice Larger, Stefano Mandelli, Lorenzo Perugini, Silvia Giambuzzi, Sabrina Pucci, PierLuigi Toro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:2653-2658
Starting from a orexin 1 receptor selective antagonist 4,4-disubstituted piperidine series a novel potent 5-azaspiro[2.4]heptane dual orexin 1 and orexin 2 receptor antagonist class has been discovered. SAR and Pharmacokinetic optimization of this se