Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19

Autor: Magdalene Joseph, Yin Wu, Richard Dannebaum, Florian Rubelt, Iva Zlatareva, Anna Lorenc, Zhipei Gracie Du, Daniel Davies, Fernanda Kyle-Cezar, Abhishek Das, Sarah Gee, Jeffrey Seow, Carl Graham, Dilduz Telman, Clara Bermejo, Hai Lin, Hosseinali Asgharian, Adam G. Laing, Irene del Molino del Barrio, Leticia Monin, Miguel Muñoz-Ruiz, Duncan R. McKenzie, Thomas S. Hayday, Isaac Francos-Quijorna, Shraddha Kamdar, Richard Davis, Vasiliki Sofra, Florencia Cano, Efstathios Theodoridis, Lauren Martinez, Blair Merrick, Karen Bisnauthsing, Kate Brooks, Jonathan Edgeworth, John Cason, Christine Mant, Katie J. Doores, Pierre Vantourout, Khai Luong, Jan Berka, Adrian C. Hayday

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(34)

Whereas pathogen-specific T and B cells are a primary focus of interest during infectious disease, we have used COVID-19 to ask whether their emergence comes at a cost of broader B cell and T cell repertoire disruption. We applied a genomic DNA-based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d30cd379a7c09962953e558243f5a1
https://pubmed.ncbi.nlm.nih.gov/35943978

Haplotyping germline and cancer genomes with high-throughput linked-read sequencing

Autor: Rajiv Bharadwaj, Hanlee P. Ji, Serge Saxonov, Alex Kindwall, Melissa Luo, Patrick Marks, Clara Bermejo, Landon Merrill, Francesca Meschi, Jessica M. Terry, Adrian Fehr, John Bell, Gerard M Vurens, Kristina Giorda, Adam Lowe, Heather Ordonez, Michael Schnall-Levin, Jorge Bernate, Josephine Y Lee, Phillip Belgrader, Glenn K. Lockwood, Steven W Short, Sukhvinder Kaur, Shawn Gauby, Lawrence Greenfield, Geoffrey P. McDermott, Stephanie Greer, Pranav Patel, Andrew D. Price, Benjamin J. Hindson, Nikola O Kondov, Grace X.Y. Zheng, Sofia Kyriazopoulou-Panagiotopoulou, David E Birch, Luz Montesclaros, Alexander Wong, Kamila Belhocine, Susan M. Grimes, Ryan Wilson, Donald A. Masquelier, Patrice A Mudivarti, Kevin D. Ness, Mirna Jarosz, Adrian Chan, Indira Wu, Erik S. Hopmans, Paul Wyatt, David Stafford, Paul Hardenbol, Anthony J. Makarewicz, Joshua Delaney, Yuan Li, Zachary Bent, Christopher Hindson, Christina Wood, Keith Bjornson, Billy T. Lau, William Haynes Heaton

Publikováno v: Nature biotechnology, vol 34, iss 3

Haplotyping of human chromosomes is a prerequisite for cataloguing the full repertoire of genetic variation. We present a microfluidics-based, linked-read sequencing technology that can phase and haplotype germline and cancer genomes using nanograms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61cceca38f7f8889494f6c31fa5fc631
https://escholarship.org/uc/item/0z84g4gh

Functional and genomic analyses of blocked protein O-mannosylation in baker's yeast

Autor: Pedro Botías, Johannes Hutzler, Andrea Schott, Jesús García-Cantalejo, Enrico Ragni, Heidi Piberger, Sabine Strahl, Ana Belen Sanz, Javier Arroyo, Clara Bermejo

Publikováno v: Molecular Microbiology. 79:1529-1546

Summary O-mannosylation is a crucial protein modification in eukaryotes that is initiated by the essential family of protein O-mannosyltransferases (PMTs). Here we demonstrate that in the model yeast Saccharomyces cerevisiae rhodanine-3-acetic acid d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08d363ea36db10e4c81a2c4b83734d1b
https://doi.org/10.1111/j.1365-2958.2011.07537.x

Different modulation of the outputs of yeast MAPK-mediated pathways by distinct stimuli and isoforms of the dual-specificity phosphatase Msg5

Autor: Clara Bermejo, Humberto Martín, María José Marín, María Molina, Marta Flández, Javier Arroyo

Publikováno v: Molecular Genetics and Genomics. 281:345-359

The activity of protein phosphatases on mitogen-activated protein kinases (MAPKS) is essential in the modulation of the final outcome of MAPK-signalling pathways. The yeast dual-specificity phosphatase (DSP) Msg5, expressed as two isoforms of differe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bfad503ef822290acd244815b21e1e2
https://doi.org/10.1007/s00438-008-0415-5

Genomic profiling of fungal cell wall-interfering compounds: identification of a common gene signature

Autor: José L. Revuelta, César Nombela, Clara Bermejo, Raúl García, José Manuel Rodríguez-Peña, Javier Botet, Juan Carlos Ribas, Javier Arroyo

Publikováno v: BMC Genomics
Digital.CSIC. Repositorio Institucional del CSIC
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
E-Prints Complutense. Archivo Institucional de la UCM

[Background]: The fungal cell wall forms a compact network whose integrity is essential for cell morphology and viability. Thus, fungal cells have evolved mechanisms to elicit adequate adaptive responses when cell wall integrity (CWI) is compromised.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09cc91fe88fd1c7592e18e97baf2baa1
http://europepmc.org/articles/PMC4560923