Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Clara Barrio-Garcia"'
Autor:
Santiago Barrio, Umair Munawar, Yuan Xiao Zhu, Nicola Giesen, Chang-Xin Shi, Matteo Da Viá, Ricardo Sanchez, Laura Bruins, Theresa Demler, Nicole Müller, Larissa Haertle, Andoni Garitano, Torsten Steinbrunn, Sophia Danhof, Isabel Cuenca, Clara Barrio-Garcia, Esteban Braggio, Andreas Rosenwald, Joaquin Martinez-Lopez, Leo Rasche, Marc S. Raab, A. Keith Stewart, Hermann Einsele, Thorsten Stühmer, K. Martin Kortüm
Publikováno v:
Haematologica, Vol 105, Iss 5 (2020)
Externí odkaz:
https://doaj.org/article/e19b4d01458b474b8355f2aae19fde17
Autor:
Anne Preis, Andre Heuer, Clara Barrio-Garcia, Andreas Hauser, Daniel E. Eyler, Otto Berninghausen, Rachel Green, Thomas Becker, Roland Beckmann
Publikováno v:
Cell Reports, Vol 8, Iss 1, Pp 59-65 (2014)
Termination and ribosome recycling are essential processes in translation. In eukaryotes, a stop codon in the ribosomal A site is decoded by a ternary complex consisting of release factors eRF1 and guanosine triphosphate (GTP)-bound eRF3. After GTP h
Externí odkaz:
https://doaj.org/article/15fd0e18d40f49a0a9b67c4687f05f60
Autor:
Torsten Steinbrunn, K. Martin Kortüm, Thorsten Stühmer, Ricardo Sanchez, Hermann Einsele, Chang Xin Shi, Joaquin Martinez-Lopez, Marc S. Raab, Nicole Müller, Sophia Danhof, Umair Munawar, Yuan Xiao Zhu, Andoni Garitano, Esteban Braggio, Larissa Haertle, Theresa Demler, Nicola Giesen, A. Keith Stewart, Santiago Barrio, Clara Barrio-Garcia, Andreas Rosenwald, Laura Ann Bruins, Matteo Claudio Da Via, Leo Rasche, Isabel Cuenca
Publikováno v:
Haematologica
The work was supported by the Deutsche Forschungsgemeinschaft (KFO216), the IZKF, the BTHA and the CDW Stiftung (KMK). UM was supported by a grant of the German Excellence Initiative to the Graduate School of Life Sciences, University of Wurzburg.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c35095fd130d7b283f0df8147bf1737
https://europepmc.org/articles/PMC7193510/
https://europepmc.org/articles/PMC7193510/
Autor:
Clara Barrio-Garcia, Roland Beckmann, Matthias Thoms, Ed Hurt, Dirk Flemming, Emma Thomson, Anshuk Sarkar
Publikováno v:
Nature Structural & Molecular Biology. 24:1107-1115
Assembly of fully functional ribosomes is a prerequisite for failsafe translation. This explains why maturing preribosomal subunits have to pass through an array of quality-control checkpoints, including nuclear export, to ensure that only properly a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81042cfaf9b170e1573796d034035b60
https://doi.org/10.1038/nsmb.3495
https://doi.org/10.1038/nsmb.3495
Autor:
Andrej Besse, Andreas Rosenwald, Severin Fink, Matteo DaVia, Manik Chatterjee, Marc S. Raab, Isabel Cuenca, Clara Barrio-Garcia, Joaquin Martinez-Lopez, Andoni Garitano-Trojaola, A. Keith Stewart, Roland Beckmann, Nicola Lehners, Esteban Braggio, Thorsten Stühmer, Santiago Barrio, K. Martin Kortüm, Ellen Leich, Ralf C. Bargou, Christoph Driessen, Hermann Einsele
Publikováno v:
Leukemia. 33(2)
Despite an increasing number of approved therapies, multiple myeloma (MM) remains an incurable disease and only a small number of patients achieve prolonged disease control. Some genes have been linked with response to commonly used anti-MM compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995d36449bb1f12935cb8af48d7a6d1a
https://pubmed.ncbi.nlm.nih.gov/30026573
https://pubmed.ncbi.nlm.nih.gov/30026573
Autor:
Marko Gogala, Clara Barrio-Garcia, B. Beatrix, Roland Beckmann, Thomas Becker, Jean Paul Armache, Otto Berninghausen
Publikováno v:
Nature. 506:107-110
The biogenesis of secretory as well as transmembrane proteins requires the activity of the universally conserved protein-conducting channel (PCC), the Sec61 complex (SecY complex in bacteria). In eukaryotic cells the PCC is located in the membrane of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afc9da30fbd515f922629ebb9803b458
https://doi.org/10.1038/nature12950
https://doi.org/10.1038/nature12950
Autor:
Ed Hurt, Jochen Baßler, Woonghee Lee, Sander Granneman, Gunter Stier, Clara Barrio-Garcia, Afua Nyarko, Helge Paternoga, Irmi Sinning, Sarah A. Clark, Daniel Schraivogel, Iris Holdermann, Elisar Barbar, David Tollervey, Martina Kallas, Roland Beckmann, Matthias Thoms
Publikováno v:
The Journal of Cell Biology
Baßler, J, Paternoga, H, Holdermann, I, Thoms, M, Granneman, S, Barrio-Garcia, C, Nyarko, A, Stier, G, Clark, S A, Schraivogel, D, Kallas, M, Beckmann, R, Tollervey, D, Barbar, E, Sinning, I & Hurt, E 2014, ' A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation ', Journal of Cell Biology, vol. 207, no. 4, pp. 481-498 . https://doi.org/10.1083/jcb.201408111
Baßler, J, Paternoga, H, Holdermann, I, Thoms, M, Granneman, S, Barrio-Garcia, C, Nyarko, A, Stier, G, Clark, S A, Schraivogel, D, Kallas, M, Beckmann, R, Tollervey, D, Barbar, E, Sinning, I & Hurt, E 2014, ' A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation ', Journal of Cell Biology, vol. 207, no. 4, pp. 481-498 . https://doi.org/10.1083/jcb.201408111
The assembly factor heterodimer Rsa4–Nsa2 binds to the preribosome and transmits remodeling energy from the force-generating ATPase Rea1 to facilitate relocation of ribosomal RNA elements during ribosome maturation.
Eukaryotic ribosome biogene
Eukaryotic ribosome biogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1975fe24047715e618d2d9bf3738d724
http://europepmc.org/articles/PMC4242840
http://europepmc.org/articles/PMC4242840
Autor:
Yasar Luqman Ahmed, Matthias Thoms, Jingdong Cheng, Otto Berninghausen, Lukas Kater, Gert Bange, Sherif Ismail, Clara Barrio-Garcia, Roland Beckmann, Dieter Kressler, Ed Hurt, Irmgard Sinning
Publikováno v:
'Cell ', vol: 171, pages: 1599-1610 (2017)
Cell
Cell
Summary Eukaryotic 60S ribosomal subunits are comprised of three rRNAs and ∼50 ribosomal proteins. The initial steps of their formation take place in the nucleolus, but, owing to a lack of structural information, this process is poorly understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37fb0c872eb9ca0bb47499aeda05b0c
https://doi.org/10.1016/j.cell.2017.11.039
https://doi.org/10.1016/j.cell.2017.11.039
Autor:
Lukas Kater, Clara Barrio-Garcia, Dirk Flemming, Roland Beckmann, Matthias Thoms, Ed Hurt, Jochen Baßler, Otto Berninghausen
Publikováno v:
Nature structuralmolecular biology. 23(1)
Ribosome synthesis is catalyzed by ∼200 assembly factors, which facilitate efficient production of mature ribosomes. Here, we determined the cryo-EM structure of a Saccharomyces cerevisiae nucleoplasmic pre-60S particle containing the dynein-relate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e078c60e2d65d63f547dbacf460064c1
https://pubmed.ncbi.nlm.nih.gov/26733218
https://pubmed.ncbi.nlm.nih.gov/26733218
Autor:
Manik Chatterjee, Eva Teufel, Clara Barrio-Garcia, K. Martin Kortüm, Thorsten Stühmer, Andreas Rosenwald, Santiago Barrio, Raoul Tibes, Esteban Braggio, Ralf C. Bargou, Hermann Einsele, A. Keith Stewart, Mithun Das Gupta, Martin Schreder
Publikováno v:
Blood. 128:3282-3282
Introduction: Proteasome inhibition is the backbone of various Multiple Myeloma (MM) treatment regimens, leading to durable responses and high quality remissions. However, under prolonged therapy patients eventually develop drug resistance and the un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71be7839c2f0cd44c09ea374496d81f4
https://doi.org/10.1182/blood.v128.22.3282.3282
https://doi.org/10.1182/blood.v128.22.3282.3282