Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Clara Alsinet"'
Autor:
Clara Alsinet, Maria Nascimento Primo, Valentina Lorenzi, Erica Bello, Iva Kelava, Carla P. Jones, Roser Vilarrasa-Blasi, Carmen Sancho-Serra, Andrew J. Knights, Jong-Eun Park, Beata S. Wyspianska, Gosia Trynka, David F. Tough, Andrew Bassett, Daniel J. Gaffney, Damiana Alvarez-Errico, Roser Vento-Tormo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The myeloid lineage is central to homeostasis and immunity. The authors provide an atlas of human iPSC-to-myeloid cell differentiation and demonstrate that the in vitro system recapitulates yolk sac differentiation, opening new avenues to human myelo
Externí odkaz:
https://doaj.org/article/ff14b8d69b054e38a5e0e2b1247d1b45
Autor:
Caitlin B. Conboy, Germán L. Vélez‐Reyes, Barbara R. Tschida, Hsiangyu Hu, Gabriel Kaufmann, Nicholas Koes, Bryant Keller, Clara Alsinet, Helena Cornellà, Roser Pinyol, Juan E. Abrahante, Nuri A. Temiz, Michael A. Linden, Khalid Amin, Timothy P. Kuka, Vincent W. Keng, Josep M. Llovet, Timothy K. Starr, David A. Largaespada
Publikováno v:
Hepatology Communications, Vol 3, Iss 11, Pp 1496-1509 (2019)
Each year, more than 25,000 people succumb to liver cancer in the United States, and this neoplasm represents the second cause of cancer‐related death globally. R‐spondins (RSPOs) are secreted regulators of Wnt signaling that function in developm
Externí odkaz:
https://doaj.org/article/0eab1ccaa58a47a08d90c0ba26613dba
Autor:
Theodoros I. Roumeliotis, Steven P. Williams, Emanuel Gonçalves, Clara Alsinet, Martin Del Castillo Velasco-Herrera, Nanne Aben, Fatemeh Zamanzad Ghavidel, Magali Michaut, Michael Schubert, Stacey Price, James C. Wright, Lu Yu, Mi Yang, Rodrigo Dienstmann, Justin Guinney, Pedro Beltrao, Alvis Brazma, Mercedes Pardo, Oliver Stegle, David J. Adams, Lodewyk Wessels, Julio Saez-Rodriguez, Ultan McDermott, Jyoti S. Choudhary
Publikováno v:
Cell Reports, Vol 20, Iss 9, Pp 2201-2214 (2017)
Assessing the impact of genomic alterations on protein networks is fundamental in identifying the mechanisms that shape cancer heterogeneity. We have used isobaric labeling to characterize the proteomic landscapes of 50 colorectal cancer cell lines a
Externí odkaz:
https://doaj.org/article/d6175c0cd7e54e1f86973be608f9900c
Autor:
Brandon T. Wesley, Alexander D. B. Ross, Daniele Muraro, Zhichao Miao, Sarah Saxton, Rute A. Tomaz, Carola M. Morell, Katherine Ridley, Ekaterini D. Zacharis, Sandra Petrus-Reurer, Judith Kraiczy, Krishnaa T. Mahbubani, Stephanie Brown, Jose Garcia-Bernardo, Clara Alsinet, Daniel Gaffney, Dave Horsfall, Olivia C. Tysoe, Rachel A. Botting, Emily Stephenson, Dorin-Mirel Popescu, Sonya MacParland, Gary Bader, Ian D. McGilvray, Daniel Ortmann, Fotios Sampaziotis, Kourosh Saeb-Parsy, Muzlifah Haniffa, Kelly R. Stevens, Matthias Zilbauer, Sarah A. Teichmann, Ludovic Vallier
Publikováno v:
Nature Cell Biology. 24:1487-1498
The liver has been studied extensively due to the broad number of diseases affecting its vital functions. However, therapeutic advances have been hampered by the lack of knowledge concerning human hepatic development. Here, we addressed this limitati
Autor:
Helen L. Reeves, Nicola J. Curtin, Geoffrey I. Shapiro, Derek M. Manas, John Rose, David Newell, Alastair D. Burt, Jennifer Jackson, Huw D. Thomas, Despina Televantou, Catherine E. Willoughby, Laura Ogle, Augusto Villanueva, Clara Alsinet, Joanne M. Munck, Liam Cornell
Supplementary Figures 1-11. Supplementary Figure 1. DNA-PK expression and tumour specific PRKDC locus amplification Supplementary Figure 2. DDR gene expression in HCC cells Supplementary Figure 3: DDR protein expression and activity in HCC cells Supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7579644ee811838f9fe1ccae59f6d9
https://doi.org/10.1158/1078-0432.22458081.v1
https://doi.org/10.1158/1078-0432.22458081.v1
Autor:
Josep M. Llovet, Scott L. Friedman, Myron Schwartz, Vincenzo Mazzaferro, Jordi Bruix, Stephen C. Ward, Swan Thung, Jordi Barretina, Hung-Wen Tsai, Philippa Newell, Beatriz Minguez, Augusto Villanueva, Yujin Hoshida, Sara Toffanin, Laia Cabellos, Radoslav Savic, Clara Alsinet, Anja Lachenmayer
PDF file, 10.8MB, Supplementary Table 1: Clinical characteristics of human hepatocellular carcinoma samples. Supplementary Table 2: Clinical Characteristics of 5 public HCC datasets. Supplementary Table 3: Wnt-pathway mRNA list: 210 Wnt-related genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f7bc1a4563b714df9e6c108a776a695
https://doi.org/10.1158/1078-0432.22444386.v1
https://doi.org/10.1158/1078-0432.22444386.v1
Autor:
Helen L. Reeves, Nicola J. Curtin, Geoffrey I. Shapiro, Derek M. Manas, John Rose, David Newell, Alastair D. Burt, Jennifer Jackson, Huw D. Thomas, Despina Televantou, Catherine E. Willoughby, Laura Ogle, Augusto Villanueva, Clara Alsinet, Joanne M. Munck, Liam Cornell
Data Supplement from DNA-PK—A Candidate Driver of Hepatocarcinogenesis and Tissue Biomarker That Predicts Response to Treatment and Survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8349f353f38afcfccaa5656e5483e61f
https://doi.org/10.1158/1078-0432.22458087
https://doi.org/10.1158/1078-0432.22458087
Autor:
Helen L. Reeves, Nicola J. Curtin, Geoffrey I. Shapiro, Derek M. Manas, John Rose, David Newell, Alastair D. Burt, Jennifer Jackson, Huw D. Thomas, Despina Televantou, Catherine E. Willoughby, Laura Ogle, Augusto Villanueva, Clara Alsinet, Joanne M. Munck, Liam Cornell
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f979d7716d1e33d9b90cf9dbe311d0f
https://doi.org/10.1158/1078-0432.22458078.v1
https://doi.org/10.1158/1078-0432.22458078.v1
Autor:
Helen L. Reeves, Nicola J. Curtin, Geoffrey I. Shapiro, Derek M. Manas, John Rose, David Newell, Alastair D. Burt, Jennifer Jackson, Huw D. Thomas, Despina Televantou, Catherine E. Willoughby, Laura Ogle, Augusto Villanueva, Clara Alsinet, Joanne M. Munck, Liam Cornell
Purpose: Therapy resistance and associated liver disease make hepatocellular carcinomas (HCC) difficult to treat with traditional cytotoxic therapies, whereas newer targeted approaches offer only modest survival benefit. We focused on DNA-dependent p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002702d869d48dc70705473b83b1ae1f
https://doi.org/10.1158/1078-0432.c.6523821
https://doi.org/10.1158/1078-0432.c.6523821
Autor:
Helen L. Reeves, Nicola J. Curtin, Geoffrey I. Shapiro, Derek M. Manas, John Rose, David Newell, Alastair D. Burt, Jennifer Jackson, Huw D. Thomas, Despina Televantou, Catherine E. Willoughby, Laura Ogle, Augusto Villanueva, Clara Alsinet, Joanne M. Munck, Liam Cornell
Supplementary Tables 1-2. Supplementary Table 1. Clinical features of the subset of patients receiving palliative TACE as first line therapy Supplementary Table 2 - Tumour Factors associated with survival in cohort two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29493c84a6ca5742c836f6d7ac944d49
https://doi.org/10.1158/1078-0432.22458075.v1
https://doi.org/10.1158/1078-0432.22458075.v1