Kinetic models for estimating occupancy from single-scan PET displacement studies

Autor: Gjertrud Louise Laurell, Pontus Plavén-Sigray, Annette Johansen, Nakul Ravi Raval, Arafat Nasser, Clara Aabye Madsen, Jacob Madsen, Hanne Demant Hansen, Lene Lundgaard Donovan, Gitte Moos Knudsen, Adriaan A Lammertsma, R Todd Ogden, Claus Svarer, Martin Schain

Publikováno v: Laurell, G L, Plavén-Sigray, P, Johansen, A, Raval, N R, Nasser, A, Aabye Madsen, C, Madsen, J, Hansen, H D, Donovan, L L, Knudsen, G M, Lammertsma, A A, Ogden, R T, Svarer, C & Schain, M 2023, ' Kinetic models for estimating occupancy from single-scan PET displacement studies ', Journal of Cerebral Blood Flow and Metabolism . https://doi.org/10.1177/0271678X231168591
Journal of Cerebral Blood Flow and Metabolism. Nature Publishing Group

The traditional design of PET target engagement studies is based on a baseline scan and one or more scans after drug administration. We here evaluate an alternative design in which the drug is administered during an on-going scan (i.e., a displacemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8f95e56fbb9c6f1084263313de0b41
http://www.scopus.com/inward/record.url?scp=85153370411&partnerID=8YFLogxK

Evaluation of the α-synuclein PET radiotracer (d

Autor: Nakul Ravi, Raval, Clara Aabye, Madsen, Vladimir, Shalgunov, Arafat, Nasser, Umberto Maria, Battisti, Emily Eufaula, Beaman, Morten, Juhl, Louise Møller, Jørgensen, Matthias Manfred, Herth, Hanne Demant, Hansen, Pontus, Plavén-Sigray, Gitte Moos, Knudsen

Publikováno v: Nuclear medicine and biology.

A positron emission tomography (PET) radiotracer to neuroimage α-synuclein aggregates would be a crucial addition for early diagnosis and treatment development in disorders such as Parkinson's disease, where elevated aggregate levels are a histopath

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8edf976ac84129848ee66e4d4d561406
https://pubmed.ncbi.nlm.nih.gov/36095921

An in vivo pig model for testing novel PET radioligands targeting cerebral protein aggregates

Autor: Nakul Ravi Raval, Arafat Nasser, Clara Aabye Madsen, Natalie Beschorner, Emily Eufaula Beaman, Morten Juhl, Szabolcs Lehel, Mikael Palner, Claus Svarer, Pontus Plavén-Sigray, Louise Møller Jørgensen, Gitte Moos Knudsen

Positron emission tomography (PET) has become an essential clinical tool for diagnosing neurodegenerative diseases with abnormal accumulation of proteins like amyloid-β or tau. Despite many attempts, it has not been possible to develop an appropriat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbb153895d97607447f7741a4f9d2f6f
https://doi.org/10.1101/2021.12.31.473908