Výsledky vyhledávání - "Clara A. Michell"

Akademický článek

Hypertrophic Cardiomyopathy Cardiac Troponin C Mutations Differentially Affect Slow Skeletal and Cardiac Muscle Regulation

Autor: Jose R. Pinto, Tiago Veltri, Maicon Landim-Vieira, Michelle S. Parvatiyar, David Gonzalez-Martinez, Karissa M. Dieseldorff Jones, Clara A. Michell, David Dweck, Andrew P. Landstrom, P. Bryant Chase

Publikováno v: Frontiers in Physiology, Vol 8 (2017)

Mutations in TNNC1—the gene encoding cardiac troponin C (cTnC)—that have been associated with hypertrophic cardiomyopathy (HCM) and cardiac dysfunction may also affect Ca2+-regulation and function of slow skeletal muscle since the same gene is ex

Externí odkaz: https://doaj.org/article/de0f01d82986440e8a1a28beedc74a76

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Hypertrophic Cardiomyopathy Cardiac Troponin C Mutations Differentially Affect Slow Skeletal and Cardiac Muscle Regulation

Autor: David Gonzalez-Martinez, Karissa M. Dieseldorff Jones, Maicon Landim-Vieira, Michelle S. Parvatiyar, Jose R. Pinto, Andrew P. Landstrom, P. Bryant Chase, Clara A. Michell, Tiago Veltri, David Dweck

Publikováno v: Frontiers in Physiology
Frontiers in Physiology, Vol 8 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567e97ff05486230ba0f1424f179d0c3
http://europepmc.org/articles/PMC5397416

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Enhanced troponin I binding explains the functional changes produced by the hypertrophic cardiomyopathy mutation A8V of cardiac troponin C

Autor: Clara A. Michell, Maicon Landim-Vieira, Henry G. Zot, Jose R. Pinto, Javier E. Hasbun

Publikováno v: Archives of biochemistry and biophysics. 601

Higher affinity for TnI explains how troponin C (TnC) carrying a causative hypertrophic cardiomyopathy mutation, TnC(A8V), sensitizes muscle cells to Ca(2+). Muscle fibers reconstituted with TnC(A8V) require ∼2.3-fold less [Ca(2+)] to achieve 50% m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5dbb80436d1ae7bb1de0988bc6789a
https://pubmed.ncbi.nlm.nih.gov/26976709

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The Functional Consequences of Hypertrophic Cardiomyopathy Troponin C Mutations in the Regulation of Slow Skeletal Muscle Contraction: The Protective Role of Slow Skeletal Troponin I

Autor: David Dweck, Clara A. Michell, Maicon Landim, Tiago Veltri, Jose R. Pinto

Publikováno v: Biophysical Journal. 108(2):593a-594a

Mutations in cardiac troponin C (cTnC) have been linked to hypertrophic cardiomyopathy (HCM) in humans. The cTnC subunit of the troponin complex is expressed in both slow skeletal and cardiac muscle. The cTnC HCM mutations A8V, C84Y and D145E increas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01dd66514c908b28d1e938dd3346229

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