Using rare genetic mutations to revisit structural brain asymmetry

Autor: Jakub Kopal, Kuldeep Kumar, Kimia Shafighi, Karin Saltoun, Claudia Modenato, Clara A. Moreau, Guillaume Huguet, Martineau Jean-Louis, Charles-Olivier Martin, Zohra Saci, Nadine Younis, Elise Douard, Khadije Jizi, Alexis Beauchamp-Chatel, Leila Kushan, Ana I. Silva, Marianne B. M. van den Bree, David E. J. Linden, Michael J. Owen, Jeremy Hall, Sarah Lippé, Bogdan Draganski, Ida E. Sønderby, Ole A. Andreassen, David C. Glahn, Paul M. Thompson, Carrie E. Bearden, Robert Zatorre, Sébastien Jacquemont, Danilo Bzdok

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Asymmetry between the left and right hemisphere is a key feature of brain organization. Hemispheric functional specialization underlies some of the most advanced human-defining cognitive operations, such as articulated language, perspective

Externí odkaz: https://doaj.org/article/ef8661c3f98b45db8c8b23d96d4aa318

Pervasive alterations of intra-axonal volume and network organization in young children with a 16p11.2 deletion

Autor: Anne M. Maillard, David Romascano, Julio E. Villalón-Reina, Clara A. Moreau, Joana M. Almeida Osório, Sonia Richetin, Vincent Junod, Paola Yu, Bratislav Misic, Paul M. Thompson, Eleonora Fornari, Marine Jequier Gygax, Sébastien Jacquemont, Nadia Chabane, Borja Rodríguez-Herreros

Publikováno v: Translational Psychiatry, Vol 14, Iss 1, Pp 1-11 (2024)

Abstract Reciprocal Copy Number Variants (CNVs) at the 16p11.2 locus confer high risk for autism spectrum disorder (ASD) and other neurodevelopmental disorders (NDDs). Morphometric MRI studies have revealed large and pervasive volumetric alterations

Externí odkaz: https://doaj.org/article/121a97baafcc44908fd271c280ac677e

Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia

Autor: Clara A. Moreau, Sebastian G. W. Urchs, Kumar Kuldeep, Pierre Orban, Catherine Schramm, Guillaume Dumas, Aurélie Labbe, Guillaume Huguet, Elise Douard, Pierre-Olivier Quirion, Amy Lin, Leila Kushan, Stephanie Grot, David Luck, Adrianna Mendrek, Stephane Potvin, Emmanuel Stip, Thomas Bourgeron, Alan C. Evans, Carrie E. Bearden, Pierre Bellec, Sebastien Jacquemont

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

The impact of neurodevelopmental mutations on functional brain connectivity is poorly understood. Here the authors identify thalamo-sensorimotor dysconnectivity dimensions shared across 16p11.2 and 22q11.2 copy number variants, autism and schizophren

Externí odkaz: https://doaj.org/article/c8046adb9f7945e59d7f1cd01bd68a9a

Using rare genetic mutations to revisit structural brain asymmetry

Autor: Jakub Kopal, Kuldeep Kumar, Kimia Shafighi, Karin Saltoun, Claudia Modenato, Clara A. Moreau, Guillaume Huguet, Martineau Jean-Louis, Charles-Olivier Martin, Zohra Saci, Nadine Younis, Elise Douard, Khadije Jizi, Alexis Beauchamp-Chatel, Leila Kushan, Ana I. Silva, Marianne B. M. van den Bree, David E. J. Linden, Michael J. Owen, Jeremy Hall, Sarah Lippé, Bogdan Draganski, Ida E. Sønderby, Ole A. Andreassen, David C. Glahn, Paul M. Thompson, Carrie E. Bearden, Robert Zatorre, Sébastien Jacquemont, Danilo Bzdok

Publikováno v: bioRxiv

Asymmetry between the left and right brain is a key feature of brain organization. Hemispheric functional specialization underlies some of the most advanced human-defining cognitive operations, such as articulated language, perspective taking, or rap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78fe84663289579aa4d6b70082c1c61
https://europepmc.org/articles/PMC10153125/

Genetic Heterogeneity Shapes Brain Connectivity in Psychiatry

Autor: Clara A. Moreau, Annabelle Harvey, Kuldeep Kumar, Guillaume Huguet, Sebastian G.W. Urchs, Elise A. Douard, Laura M. Schultz, Hanad Sharmarke, Khadije Jizi, Charles-Olivier Martin, Nadine Younis, Petra Tamer, Thomas Rolland, Jean-Louis Martineau, Pierre Orban, Ana Isabel Silva, Jeremy Hall, Marianne B.M. van den Bree, Michael J. Owen, David E.J. Linden, Aurelie Labbe, Sarah Lippé, Carrie E. Bearden, Laura Almasy, David C. Glahn, Paul M. Thompson, Thomas Bourgeron, Pierre Bellec, Sebastien Jacquemont

Publikováno v: Biological Psychiatry, 93(1), 45-58. Elsevier Science
Biological Psychiatry
Biological Psychiatry, 2023, 93 (1), pp.54-58. ⟨10.1016/j.biopsych.2022.08.024⟩

BACKGROUND: Polygenicity and genetic heterogeneity pose great challenges for studying psychiatric conditions. Genetically informed approaches have been implemented in neuroimaging studies to address this issue. However, the effects on functional conn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce433d4df8befcff0fb52e3af85ff4c
https://cris.maastrichtuniversity.nl/en/publications/9d5f2737-1bee-4a27-902b-bb9a7103676d