Zobrazeno 1 - 10
of 476
pro vyhledávání: '"Clara, Toma"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 9, p e1010116 (2022)
Transcription factors (TFs) are crucial for regulating cell differentiation during the development of the immune system. However, the key TFs for orchestrating the specification of distinct immune cells are not fully understood. Here, we integrated t
Externí odkaz:
https://doaj.org/article/bc7981ec099740778a7e8a256b3913c2
Autor:
John T. Crowl, Maximilian Heeg, Amir Ferry, J. Justin Milner, Kyla D. Omilusik, Clara Toma, Zhaoren He, John T. Chang, Ananda W. Goldrath
Publikováno v:
Nat Immunol
Nature immunology, vol 23, iss 7
Nature immunology, vol 23, iss 7
Tissue-resident memory T cells (T(RM) cells) provide protective immunity, but the contributions of specific tissue environments to T(RM) cell differentiation and homeostasis are not well understood. In the present study, the diversity of gene express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071a46f29b7678c014a5975706c2a1fe
https://doi.org/10.1038/s41590-022-01229-8
https://doi.org/10.1038/s41590-022-01229-8
Autor:
Adam J. Getzler, Megan A. Frederick, Justin J. Milner, Thomas Venables, Huitian Diao, Clara Toma, Shashank D. Nagaraja, Dominic S. Albao, Simon Bélanger, Shanel M. Tsuda, Jihye Kim, Shane Crotty, Ananda W. Goldrath, Matthew E. Pipkin
Publikováno v:
bioRxiv
CD8+T cells with stem cell-like properties (TSCM) sustain adaptive immunity to intracellular pathogens and tumors. However, the developmental origins and chromatin regulatory factors (CRFs) that establish their differentiation are unclear. Using an R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d73e585f11a72933734f7f35740eb4
https://doi.org/10.1101/2023.01.18.524461
https://doi.org/10.1101/2023.01.18.524461
Autor:
Sara Quon, Bingfei Yu, Brendan E. Russ, Kirill Tsyganov, Hongtuyet Nguyen, Clara Toma, Maximilian Heeg, James D. Hocker, J. Justin Milner, Shane Crotty, Matthew E. Pipkin, Stephen J. Turner, Ananda W. Goldrath
Publikováno v:
Immunity. 56:959
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b07a3077aba9052d04dd957315eb67c
https://doi.org/10.1016/j.immuni.2023.03.017
https://doi.org/10.1016/j.immuni.2023.03.017
Autor:
Jihye Kim, Dapeng Wang, Runqiang Chen, Clara Toma, Huitian Diao, Shane Crotty, Ananda W. Goldrath, Gustavo J. Martinez, Pabalu Karunadharma, Donna M. Martin, J. Justin Milner, Thomas Venables, Shanel Tsuda, Matthew E. Pipkin, Megan A. Frederick, Adam J. Getzler
Individual naive CD8 T cells activated in lymphoid organs differentiate into functionally diverse and anatomically distributed T cell phylogenies in response to intracellular microbes. During infections that resolve rapidly, including live viral vacc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdad561ab24d201361adde2c31ce0001
https://doi.org/10.1101/2021.08.11.456014
https://doi.org/10.1101/2021.08.11.456014
Autor:
John T, Crowl, Maximilian, Heeg, Amir, Ferry, J Justin, Milner, Kyla D, Omilusik, Clara, Toma, Zhaoren, He, John T, Chang, Ananda W, Goldrath
Publikováno v:
Nature immunology. 23(7)
Tissue-resident memory T cells (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::28e3449b38b9fb51ff86d7543bac0599
https://pubmed.ncbi.nlm.nih.gov/36089486
https://pubmed.ncbi.nlm.nih.gov/36089486
Autor:
Stephen M. Hedrick, Adam J. Getzler, Clara Toma, J. Justin Milner, Miguel Reina-Campos, Jun Qi, Adam Vincek, Bingfei Yu, Shane Crotty, Kyla D. Omilusik, Ming-Ming Zhou, Hongtuyet Nguyen, Nicole E. Scharping, Tomomi M. Yoshida, Anup Dey, Ananda W. Goldrath, Deyao Li, Huitian Diao, Takeshi Egawa, Sara Quon, Arnaud Delpoux, Matthew E. Pipkin, Keiko Ozato
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine, vol 218, iss 8
Journal of Experimental Medicine, vol 218, iss 8
BRD4 is a bromodomain-containing protein that binds acetylated histones to regulate transcription. In this issue of JEM, Milner et al. show that BRD4 plays a critical role in the effector function of CD8 T cells responding to infection and cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6981d15438129a849e1363d8752a945
https://doi.org/10.1084/jem.20202512
https://doi.org/10.1084/jem.20202512
Autor:
Stephen M. Hedrick, John T. Chang, Kyla D. Omilusik, Hongtuyet Nguyen, Matthew S. Tsai, Clara Toma, J. Justin Milner, Arnaud Delpoux, Miguel Reina-Campos, Ananda W. Goldrath, Brigid S. Boland
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 41
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Memory CD8 T cells provide durable protection against diverse intracellular pathogens and can be broadly segregated into distinct circulating and tissue-resident populations. Paradigmatic studies have demonstrated circulating memory cells can be furt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded22ad78f20cfda69b9c498279cd897
https://escholarship.org/uc/item/9f26p72t
https://escholarship.org/uc/item/9f26p72t
Autor:
Ananda W. Goldrath, John T. Chang, Kyla D. Omilusik, Bryan McDonald, John T. Crowl, Gene W. Yeo, Quynh P. Nguyen, Christella E. Widjaja, Zhaoren He, Deborah A. Witherden, J. Justin Milner, Nadia S. Kurd, Lauren K. Quezada, Clara Toma
Unremitting defense against diverse pathogens and malignancies requires a dynamic and durable immune response. Tissue-resident memory CD8+ T cells (Trm) afford robust protection against infection and cancer progression through continuous surveillance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259904011082db17e6c14df948d953c4
https://doi.org/10.1101/2020.03.05.979146
https://doi.org/10.1101/2020.03.05.979146
Autor:
Anthony T. Phan, Toan Nguyen, Adam J. Getzler, Dapeng Wang, Shane Crotty, Clara Toma, J. Justin Milner, Matthew E. Pipkin, Kai Zhang, Ananda W. Goldrath, Bingfei Yu, Wei Wang, Kyla D. Omilusik
Publikováno v:
Nature. 552:253-257
Tissue-resident memory CD8+ T (TRM) cells are found at common sites of pathogen exposure, where they elicit rapid and robust protective immune responses. However, the molecular signals that control TRM cell differentiation and homeostasis are not ful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e80d7e8c904a253d99b5b7b444e1c8e
https://doi.org/10.1038/nature24993
https://doi.org/10.1038/nature24993