Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Clara, Andonian"'
Autor:
Hermes Licea, Perez, Clara, Andonian
Publikováno v:
Bioanalysis. 14:1317-1326
Background: The instability of aldehydes in biological matrices is associated with their reactions with thiol and amino moieties in proteins. This chemical reaction is reversible by nature and highly pH dependent. Method: A novel approach that includ
Autor:
Hermes Licea Perez, Clara Andonian
Publikováno v:
Bioanalysis. 13:985-999
Aim: Quantification of stereoisomers in biological matrices is of pivotal importance for drug development. Supercritical fluid chromatography paired with chiral stationary phases is the gold standard for resolution of enantiomers. However, this techn
Autor:
William M. Hardesty, Jonathan Stauber, Lydia Benakli, Rima Ait-Belkacem, Hermes Licea-Perez, Jeremy A. Barry, Stephen Castellino, Clara Andonian
Publikováno v:
Analytical chemistry. 91(9)
The aim of this study was to assess potential sources of variability in quantitative imaging mass spectrometry (IMS) across multiple sites, analysts, and instruments. A sample from rat liver perfused with clozapine was distributed to three sites for
Autor:
Bianca Squillaci, Dung Nguyen, Mohammad Hossain, Clara Andonian, Mally Lev, Kitaw Negash, May Ho, Courtney Tiffany, Jill L. Pirhalla, Cathy L. Chen, Igor Goljer, Clive Felgate, Ernest Schubert
Publikováno v:
Xenobiotica. 46:683-702
1. GSK2140944 is a novel bacterial topoisomerase inhibitor in development for the treatment of bacterial infections. The metabolism and disposition in healthy human subjects was investigated. 2. Six male subjects received [(14)C] GSK2140944 orally (2
Autor:
Anja Rode, Xiaoyan Chu, Esaie Pierre, Thomas Wanek, Jeevan Kunta, Mario Mezler, Clara Andonian, Jocelyn Yabut, Jodie Pang, Carolin Hoft, Stéphanie Chasseigneaux, Shannon Dallas, Oliver Langer, Xiaolin Zhang, Damir Simic, David Gomez-Zepeda, Karen DiLoreto, Liangfu Chen, Loic Laplanche, Tony Pereira, Marie-Claude Menet, Laurent Salphati, Nico Scheer, Xavier Declèves
Publikováno v:
Molecular pharmacology. 89(5)
Breast cancer resistance protein (BCRP) is expressed in various tissues, such as the gut, liver, kidney and blood brain barrier (BBB), where it mediates the unidirectional transport of substrates to the apical/luminal side of polarized cells. Thereby