T cell activation Rho GTPase activating protein (TAGAP) is upregulated in clinical and experimental arthritis

Autor: Attya Bhatti, Peter John, Joanna Z. Kawalkowska, Fazal Jalil, Maria Arshad, Clanchy Fil., F Borghese, Richard O. Williams

Genome-wide association studies have identified various susceptibility variants and loci associated with incidence of rheumatoid arthritis (RA) in different populations. One of these is T cell activation Rho GTPase activating protein (TAGAP). The pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7941bf7f5bea390c52adcb5116b7751
https://doi.org/10.1016/j.cyto.2017.10.002

Modulation of immune cell function, IDO expression and kynurenine production by the quorum sensor 2-heptyl-3-hydroxy-4-quinolone (PQS).

Autor: Ogbechi J; The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculo-skeletal Sciences (NDORMS), University of Oxford, Oxford, United Kingdom., Huang YS; The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculo-skeletal Sciences (NDORMS), University of Oxford, Oxford, United Kingdom., Clanchy FIL; The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculo-skeletal Sciences (NDORMS), University of Oxford, Oxford, United Kingdom., Pantazi E; The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculo-skeletal Sciences (NDORMS), University of Oxford, Oxford, United Kingdom., Topping LM; The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculo-skeletal Sciences (NDORMS), University of Oxford, Oxford, United Kingdom., Darlington LG; Internal Medicine, Ashtead Hospital, Ashtead, United Kingdom., Williams RO; The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculo-skeletal Sciences (NDORMS), University of Oxford, Oxford, United Kingdom., Stone TW; The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculo-skeletal Sciences (NDORMS), University of Oxford, Oxford, United Kingdom.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Oct 28; Vol. 13, pp. 1001956. Date of Electronic Publication: 2022 Oct 28 (Print Publication: 2022).

Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis.

Autor: Huang YS; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, United Kingdom.; Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan., Tseng WY; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, United Kingdom.; Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.; Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital at Keelung, Keelung 20401, Taiwan., Clanchy FIL; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, United Kingdom.; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, United Kingdom., Topping LM; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, United Kingdom., Ogbechi J; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, United Kingdom., McNamee K; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, United Kingdom., Perocheau D; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, United Kingdom., Chiang NY; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, United Kingdom., Ericsson P; The Rausing Laboratory, Division of Neurosurgery, Department of Clinical Sciences, Lund University, SE-221 85 Lund, Sweden., Sundstedt A; The Rausing Laboratory, Division of Neurosurgery, Department of Clinical Sciences, Lund University, SE-221 85 Lund, Sweden.; Idogen AB, SE-223 81 Lund, Sweden., Xue ZT; The Rausing Laboratory, Division of Neurosurgery, Department of Clinical Sciences, Lund University, SE-221 85 Lund, Sweden., Salford LG; The Rausing Laboratory, Division of Neurosurgery, Department of Clinical Sciences, Lund University, SE-221 85 Lund, Sweden.; Idogen AB, SE-223 81 Lund, Sweden., Sjögren HO; The Rausing Laboratory, Division of Neurosurgery, Department of Clinical Sciences, Lund University, SE-221 85 Lund, Sweden.; Idogen AB, SE-223 81 Lund, Sweden., Stone TW; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, United Kingdom., Lin HH; Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.; Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital at Keelung, Keelung 20401, Taiwan.; Department of Anatomic Pathology, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan., Luo SF; Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan., Williams RO; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, United Kingdom; richard.williams@kennedy.ox.ac.uk.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 May 11; Vol. 118 (19).

Rationale for Early Detection of EWSR1 Translocation-Associated Sarcoma Biomarkers in Liquid Biopsy.

Autor: Clanchy FIL; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7FY, UK.; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Roosevelt Drive, Oxford OX3 7LD, UK.

Publikováno v: Cancers [Cancers (Basel)] 2021 Feb 16; Vol. 13 (4). Date of Electronic Publication: 2021 Feb 16.

Functional and phenotypic heterogeneity of Th17 cells in health and disease.

Autor: Bystrom J; William Harvey Research Institute, Queen Mary University of London, London, UK., Clanchy FIL; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Taher TE; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK., Al-Bogami M; Radiology Department, Alnakheel Medical Centre, Riyadh, Kingdom of Saudi Arabia., Ong VH; Centre for Rheumatology and Connective Tissue Diseases, University College London, Royal Free Hospital, London, UK., Abraham DJ; Centre for Rheumatology and Connective Tissue Diseases, University College London, Royal Free Hospital, London, UK., Williams RO; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Mageed RA; William Harvey Research Institute, Queen Mary University of London, London, UK.

Publikováno v: European journal of clinical investigation [Eur J Clin Invest] 2019 Jan; Vol. 49 (1), pp. e13032. Date of Electronic Publication: 2018 Nov 01.