Výsledky vyhledávání - "Claire Y. Ma"

Akademický článek

Stimulation strength controls the rate of initiation but not the molecular organisation of TCR-induced signalling

Autor: Claire Y Ma, John C Marioni, Gillian M Griffiths, Arianne C Richard

Publikováno v: eLife, Vol 9 (2020)

Millions of naïve T cells with different TCRs may interact with a peptide-MHC ligand, but very few will activate. Remarkably, this fine control is orchestrated using a limited set of intracellular machinery. It remains unclear whether changes in sti

Externí odkaz: https://doaj.org/article/f9063b882b254480ab02b1db7f0336f0

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Mitochondrial translation is required for sustained killing by cytotoxic T cells

Autor: Miriam Lisci, Doreen A. Cantrell, Lyra O. Randzavola, Julien Prudent, Philippa R. Barton, Julia M. Marchingo, Claire Y. Ma, Vincent Paupe, Jane C. Stinchcombe, Gillian M. Griffiths

Publikováno v: Signal Transduction and Targeted Therapy

T cell receptor activation of naïve CD8+ T lymphocytes initiates their maturation into effector cytotoxic T lymphocytes (CTLs), which can kill cancer and virally infected cells. Although CTLs show an increased reliance on glycolysis upon acquisition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c406421e3035a3482a2c2c127216a169

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Staggered starts in the race to T cell activation

Autor: Claire Y. Ma, Gillian M. Griffiths, Arianne C. Richard, Gordon L. Frazer

Publikováno v: Trends in immunology. 42(11)

How T lymphocytes tune their responses to different strengths of stimulation is a fundamental question in immunology. Recent work using new optogenetic, single-cell genomic, and live-imaging approaches has revealed that stimulation strength controls

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6175f1b1f0ce5fc262766b5d842afddb
https://pubmed.ncbi.nlm.nih.gov/34649777

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