Výsledky vyhledávání - "Claire T. Friel"

Akademický článek

A synthetic ancestral kinesin-13 depolymerizes microtubules faster than any natural depolymerizing kinesin

Autor: Hannah R. Belsham, Hanan M. Alghamdi, Nikita Dave, Alexandra J. Rathbone, Bill Wickstead, Claire T. Friel

Publikováno v: Open Biology, Vol 12, Iss 8 (2022)

The activity of a kinesin is largely determined by the approximately 350 residue motor domain, and this region alone is sufficient to classify a kinesin as a member of a particular family. The kinesin-13 family are a group of microtubule depolymerizi

Externí odkaz: https://doaj.org/article/2963415eaa13462580cabf2e44fe6b0d

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Akademický článek

A Cdk1 phosphomimic mutant of MCAK impairs microtubule end recognition

Autor: Hannah R. Belsham, Claire T. Friel

Publikováno v: PeerJ, Vol 5, p e4034 (2017)

The microtubule depolymerising kinesin-13, MCAK, is phosphorylated at residue T537 by Cdk1. This is the only known phosphorylation site within MCAK’s motor domain. To understand the impact of phosphorylation by Cdk1 on microtubule depolymerisation

Externí odkaz: https://doaj.org/article/7e9f035231514813ab029b656e6b9294

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Akademický článek

The family-specific α4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition

Autor: Jennifer T. Patel, Hannah R. Belsham, Alexandra J. Rathbone, Bill Wickstead, Christopher Gell, Claire T. Friel

Publikováno v: Open Biology, Vol 6, Iss 10 (2016)

Kinesins that influence the dynamics of microtubule growth and shrinkage require the ability to distinguish between the microtubule end and the microtubule lattice. The microtubule depolymerizing kinesin MCAK has been shown to specifically recognize

Externí odkaz: https://doaj.org/article/08c0f014e14f4239ae8fc59ff8100878

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Identification of key residues that regulate the interaction of kinesins with microtubule ends

Autor: Hannah R. Belsham, Claire T. Friel

Publikováno v: Cytoskeleton (Hoboken, N.j.)

Kinesins are molecular motors that use energy derived from ATP turnover to walk along microtubules, or when at the microtubule end, regulate growth or shrinkage. All kinesins that regulate microtubule dynamics have long residence times at microtubule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d273effa37fa20f06e1ead78329eaa
https://doi.org/10.1002/cm.21568

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