Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Claire S. Koechlein"'
Autor:
Kyle Spinler, Jeevisha Bajaj, Takahiro Ito, Bryan Zimdahl, Michael Hamilton, Armin Ahmadi, Claire S. Koechlein, Nikki Lytle, Hyog Young Kwon, Ferdous Anower-E-Khuda, Hao Sun, Allen Blevins, Joi Weeks, Marcie Kritzik, Jan Karlseder, Mark H. Ginsberg, Pyong Woo Park, Jeffrey D. Esko, Tannishtha Reya
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Identifying leukaemia stem cells (LSC) and defining how they drive tumourigenesis might aid in the treatment of disease. Here, the authors show that a reporter Musashi 2 can serve as a platform to effectively identify leukemic stem cells and it is us
Externí odkaz:
https://doaj.org/article/9cff1956974c4fd4bec74dfa1770589a
Autor:
Claire S. Koechlein, Jeffrey R. Harris, Timothy K. Lee, Joi Weeks, Raymond G. Fox, Bryan Zimdahl, Takahiro Ito, Allen Blevins, Seung-Hye Jung, John P. Chute, Amit Chourasia, Markus W. Covert, Tannishtha Reya
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
It is difficult to image haematopoietic stem cells (HSC) in their niche. Here, the authors present a new high-throughput computational approach to visualise HSCs in vivoat a high spatial and temporal resolution and also use a Msi2-reporter to label e
Externí odkaz:
https://doaj.org/article/eb98c9dbcd7d47d28ac28ab4c7bfb28b
Autor:
Nikki K. Lytle, Hyog Young Kwon, Michael Hamilton, Jeevisha Bajaj, Ferdous Anower-E-Khuda, Tannishtha Reya, Mark H. Ginsberg, Jeffrey D. Esko, Bryan Zimdahl, Armin Ahmadi, Kyle R. Spinler, Joi Weeks, Jan Karlseder, Claire S. Koechlein, Marcie Kritzik, Hao Sun, Pyong Woo Park, Allen Blevins, Takahiro Ito
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Intratumoral heterogeneity is a common feature of many myeloid leukemias and a significant reason for treatment failure and relapse. Thus, identifying the cells responsible for residual disease and leukemia re-growth is critical to better understandi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d060c5584d0922de3b8568c04b179d6
https://escholarship.org/uc/item/7vk3p3vd
https://escholarship.org/uc/item/7vk3p3vd
Autor:
Jeevisha Bajaj, Tannishtha Reya, Vivian G. Oehler, Allen Blevins, Takahiro Ito, Claire S. Koechlein, Gary Hardiman, Takaaki Konuma, David A. Rizzieri, Nikki K. Lytle, Hyog Young Kwon, Joi Weeks, Charles Chuah, Roman Sasik
Publikováno v:
Cell stem cell, vol 17, iss 2
SUMMARY Acute Myelogenous Leukemia (AML) is an aggressive cancer that strikes both adults and children and is frequently resistant to therapy. Thus, identifying signals needed for AML propagation is a critical step toward developing new approaches fo
Autor:
Markus W. Covert, John P. Chute, Tannishtha Reya, Takahiro Ito, Joi Weeks, Jeffrey R. Harris, Claire S. Koechlein, Timothy K. Lee, Bryan Zimdahl, Allen Blevins, Seung-Hye Jung, Raymond G. Fox, Amit Chourasia
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Although we know a great deal about the phenotype and function of haematopoietic stem/progenitor cells, a major challenge has been mapping their dynamic behaviour within living systems. Here we describe a strategy to image cells in vivo with high spa
Publikováno v:
Annual review of cell and developmental biology. 31
How a single cell gives rise to an entire organism is one of biology's greatest mysteries. Within this process, stem cells play a key role by serving as seed cells capable of both self-renewal to sustain themselves as well as differentiation to gener
Autor:
Roman Sasik, David A. Rizzieri, Takaaki Konuma, Takahiro Ito, Omead Arami, Allen Blevins, Jeevisha Bajaj, Vivian G. Oehler, Tannishtha Reya, H. Elizabeth Broome, Bryan Zimdahl, Claire S. Koechlein, Gary Hardiman, Hyog Young Kwon, Charles Chuah, Joi Weeks
Publikováno v:
Nature genetics
Cell fate can be controlled through asymmetric division and segregation of protein determinants, but the regulation of this process in the hematopoietic system is poorly understood. Here we show that the dynein-binding protein Lis1 is critically requ
Autor:
Veronica F. Hinman, Claire S. Koechlein, Alys M. Cheatle, Kristen A. Yankura, Abigail F. Cryan
A great challenge in development biology is to understand how interacting networks of regulatory genes can direct the often highly complex patterning of cells in a 3D embryo. Here, we detail the gene regulatory network that describes the distribution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fd318b75a1f8f3a96a9991949fcf8b