Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Claire S. Grierson"'
Autor:
Ioana M. Gherman, Zahraa S. Abdallah, Wei Pang, Thomas E. Gorochowski, Claire S. Grierson, Lucia Marucci
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 4 (2023)
Mechanistic models have been used for centuries to describe complex interconnected processes, including biological ones. As the scope of these models has widened, so have their computational demands. This complexity can limit their suitability when r
Externí odkaz:
https://doaj.org/article/eeee1c515cb046bfa0ba2d04147b5590
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Effective biological engineering requires the acknowledgement of evolution and its consideration during the design process. In this perspective, the authors present the concept of the evotype to reason about and shape the evolutionary potential of na
Externí odkaz:
https://doaj.org/article/8d8a5be3fdd2470dba4874351a4059ea
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Inducible gene expression systems should minimise leaky output and offer a large achievable range of expression. Here, the authors regulate transcription and translation together to suppress noise and create digital-like responses, while maintaining
Externí odkaz:
https://doaj.org/article/22f102bf191448c7a52806451b4bd2dc
Autor:
Bethany M. Eldridge, Emily R. Larson, Laura Weldon, Kevin M. Smyth, Annabelle N. Sellin, Isaac V. Chenchiah, Tanniemola B. Liverpool, Claire S. Grierson
Publikováno v:
Frontiers in Plant Science, Vol 12 (2021)
The physical presence of roots and the compounds they release affect the cohesion between roots and their environment. However, the plant traits that are important for these interactions are unknown and most methods that quantify the contributions of
Externí odkaz:
https://doaj.org/article/dad9991b33144c0d811f5445e3560dbe
Autor:
Emily R. Larson, Emily May Armstrong, Helen Harper, Sandra Knapp, Keith J. Edwards, Don Grierson, Guy Poppy, Mark W. Chase, Jonathan D. G. Jones, Ruth Bastow, Graham Jellis, Steve Barnes, Paul Temple, Matthew Clarke, Giles Oldroyd, Claire S. Grierson
Publikováno v:
New Phytologist. 238:464-469
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f98ef33b91bb9fe89a80f317ba1d3be6
https://doi.org/10.1111/nph.18663
https://doi.org/10.1111/nph.18663
Autor:
Emily May Armstrong, Emily R. Larson, Helen Harper, Cerian R. Webb, Frank Dohleman, Yoseph Araya, Claire Meade, Xiangyan Feng, Benard Mukoye, Maureece J. Levin, Benoit Lacombe, Ahmet Bakirbas, Amanda A. Cardoso, Delphine Fleury, Arthur Gessler, Deepak Jaiswal, Nawaporn Onkokesung, Varsha S. Pathare, Shyam S. Phartyal, Sanna A. Sevanto, Ida Wilson, Claire S. Grierson
Publikováno v:
New Phytologist. 238:470-481
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acbdd72b9dc93c81f103e44d16693682
https://doi.org/10.1111/nph.18771
https://doi.org/10.1111/nph.18771
Publikováno v:
ACS Synthetic Biology. 10:1598-1604
The minimal gene set for life has often been theorised, with at least ten produced forMycoplasma genitalium(M. genitalium). Due to the difficulty of usingM. genitaliumin the lab, combined with its long replication time of 12 - 15 hours, none of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9732ad3cc0031bd893547b724b1203
https://doi.org/10.1021/acssynbio.0c00515
https://doi.org/10.1021/acssynbio.0c00515
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2518
Precise control of gene expression is crucial when reprogramming the behavior of living cells. However, common inducible systems often lack the ability to stringently control gene expression due to the use of a single type of regulator that can be su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e124219d19ca2a202e725aa5fa7a645c
https://pubmed.ncbi.nlm.nih.gov/35666441
https://pubmed.ncbi.nlm.nih.gov/35666441
Publikováno v:
Current Opinion in Systems Biology
Highlights Models can investigate many more genome designs than laboratory research. Algorithms can search for genomes that optimise specific criteria. Together, models and algorithms can help engineers to design genomes. Algorithm-driven whole-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f2c1c6559de1e411df032ac6dcfb29
https://doi.org/10.1016/j.coisb.2020.10.007
https://doi.org/10.1016/j.coisb.2020.10.007
Autor:
Oliver Purcell, Joshua Rees, Oliver Chalkley, Sophie Landon, Claire S. Grierson, Lucia Marucci
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Rees-Garbutt, J, Chalkley, O, Landon, S, Purcell, O, Marucci, L & Grierson, C 2020, ' Designing Minimal Genomes Using Whole-Cell Models ', Nature Communications, vol. 11, 836 (2020) . https://doi.org/10.1038/s41467-020-14545-0
Nature Communications
Rees-Garbutt, J, Chalkley, O, Landon, S, Purcell, O, Marucci, L & Grierson, C 2020, ' Designing Minimal Genomes Using Whole-Cell Models ', Nature Communications, vol. 11, 836 (2020) . https://doi.org/10.1038/s41467-020-14545-0
Nature Communications
In the future, entire genomes tailored to specific functions and environments could be designed using computational tools. However, computational tools for genome design are currently scarce. Here we present algorithms that enable the use of design-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4237f8c8906ed9d4705d41bd34db6609
https://doaj.org/article/a2d27e6f513347d0a606d457b9efaf7f
https://doaj.org/article/a2d27e6f513347d0a606d457b9efaf7f