Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia.

Autor: Jean-Luc Perfettini, Roberta Nardacci, Mehdi Bourouba, Frédéric Subra, Laurent Gros, Claire Séror, Gwenola Manic, Filippo Rosselli, Alessandra Amendola, Peggy Masdehors, Luciana Chessa, Giuseppe Novelli, David M Ojcius, Jan Konrad Siwicki, Magdalena Chechlinska, Christian Auclair, José R Regueiro, Hugues de Thé, Marie-Lise Gougeon, Mauro Piacentini, Guido Kroemer

Publikováno v: PLoS ONE, Vol 3, Iss 6, p e2458 (2008)

DNA damage can activate the oncosuppressor protein ataxia telangiectasia mutated (ATM), which phosphorylates the histone H2AX within characteristic DNA damage foci. Here, we show that ATM undergoes an activating phosphorylation in syncytia elicited b

Externí odkaz: https://doaj.org/article/15997d8a8c2b4aaeb617c9750ec6c13c

Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection

Autor: Syed Qasim Raza, Héla Saïdi, Jean Kanellopoulos, Claire Séror, Marie Thérèse Melki, David M. Ojcius, Gian Maria Fimia, Christophe Lamaze, Jean-François Mouscadet, Audrey Paoletti, Isabelle Martins, Rita Casetti, Laurent Voisin, Marlène Bras, Mauro Piacentini, Alessandra Amendola, Guido Kroemer, Frédéric Law, Frédéric Subra, Fabiola Ciccosanti, Florence Niedergang, Marie-Lise Gougeon, Didier Métivier, Olivier Delelis, Najwane Said-Sadier, Ali A. Abdul-Sater, Laura Falasca, Nazanine Modjtahedi, Jérôme Estaquier, Jean-Luc Perfettini, Sylvain Thierry, Roberta Nardacci

Publikováno v: Journal of Experimental Medicine; Vol 208
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2011, 208 (9), pp.1823-1834. ⟨10.1084/jem.20101805⟩
The Journal of Experimental Medicine
Journal of Experimental Medicine, 2011, 208 (9), pp.1823-1834. ⟨10.1084/jem.20101805⟩

Contact with HIV-1 envelope protein elicits release of ATP through pannexin-1 channels on target cells; by activating purinergic receptors and Pyk2 kinase in target cells, this extracellular ATP boosts HIV-1 infectivity.
Extracellular adenosine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de8255f06ecca1664b78c8748ed44621
http://hdl.handle.net/2108/19411

Pro-apoptotic function of checkpoint kinase-2 in syncytia elicited by the HIV-1 envelope

Autor: Syed Qasim Raza, Claire Séror, Mauro Piacentini, Fanélie Brottes, Guido Kroemer, Jean-Luc Perfettini, Frédéric Subra

Fusogenic HIV-1 isolates induce the fusion of infected and bystander cells. Such syncytia can be found as "multinucleated giant cells" in the brain from HIV-1-infected individuals, as well as in lymphoid tissues. Syncytia elicited by the HIV-1 envelo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de445ce43b47dea089d0494e8586ea7a
http://hdl.handle.net/2108/33168

Chapter Eighteen Methods to Dissect Mitochondrial Membrane Permeabilization in the Course of Apoptosis

Autor: Lorenzo Galluzzi, Jean-Luc Perfettini, Nazanine Modjtahedi, Guido Kroemer, Oliver Kepp, Claire Séror, Ilio Vitale, Emilie Hangen

Publikováno v: Methods in Enzymology
Methods in Enzymology, pp.355-374, 2008, ⟨10.1016/S0076-6879(08)01418-3⟩

In several paradigms of cell death, mitochondrial membrane permeabilization (MMP) delimits the frontier between life and death. Mitochondria control the intrinsic pathway of apoptosis and participate in the extrinsic pathway. Moreover, they have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7444a7472bdd1ef89b8ede4dfc0ff23
https://hal.archives-ouvertes.fr/hal-02356584