Výsledky vyhledávání - "Claire Raingeval"

Akademický článek

1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery

Autor: Claire Raingeval, Olivier Cala, Béatrice Brion, Marc Le Borgne, Roderick Eliot Hubbard, Isabelle Krimm

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1218-1225 (2019)

WaterLOGSY is a sensitive ligand-observed NMR experiment for detection of interaction between a ligand and a protein and is now well-established as a screening technique for fragment-based lead discovery. Here we develop and assess a protocol to deri

Externí odkaz: https://doaj.org/article/1fff0b42fbe6468cbaef1a8378ed7a73

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NMR investigation of protein–ligand interactions for G-protein coupled receptors

Autor: Claire Raingeval, Isabelle Krimm

Publikováno v: Future Medicinal Chemistry
Future Medicinal Chemistry, Future Science, 2019, ⟨10.4155/fmc-2018-0312⟩

In this review, we report NMR studies of ligand–GPCR interactions, including both ligand-observed and protein-observed NMR experiments. Published studies exemplify how NMR can be used as a powerful tool to design novel GPCR ligands and investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c8df9503f59a13e532aaa4d4b121fe
https://doi.org/10.4155/fmc-2018-0312

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1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery

Autor: Béatrice Brion, Marc Le Borgne, Roderick E. Hubbard, Claire Raingeval, Isabelle Krimm, Olivier Cala

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2019, 34 (1), pp.1218-1225. ⟨10.1080/14756366.2019.1636235⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1218-1225 (2019)

International audience; WaterLOGSY is a sensitive ligand-observed NMR experiment for detection of interaction between a ligand and a protein and is now well-established as a screening technique for fragment-based lead discovery. Here we develop and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72b49906feecf0356e1b4ddda86419a
http://europepmc.org/articles/PMC6691826

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Fragment Linking Strategies for Structure-Based Drug Design

Autor: Alexandre Bancet, Claire Raingeval, Thierry Lomberget, Jean-François Guichou, Isabelle Krimm, Marc Le Borgne

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2020, 63 (20), pp.11420-11435. ⟨10.1021/acs.jmedchem.0c00242⟩
Journal of Medicinal Chemistry, 2020, 63 (20), pp.11420-11435. ⟨10.1021/acs.jmedchem.0c00242⟩

International audience; Fragment-based drug discovery is a strategy widely used in both academia and pharmaceutical companies to generate small-molecule protein inhibitors and drug candidates. Among the approaches reported in the literature (growing,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c05ee129f575cbff72f7c36846be933
https://hal.archives-ouvertes.fr/hal-03045139

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Miniaturized weak affinity chromatography for ligand identification of nanodiscs-embedded G-protein coupled receptors

Autor: Claire Raingeval, Claire Demesmay, Renaud Wagner, Lucie Hartmann, Lydia N. Caro, Vincent Dugas, Sarah Mohamed-Bouteben, Lucile Lecas, Isabelle Krimm

Publikováno v: Analytica Chimica Acta
Analytica Chimica Acta, Elsevier Masson, 2020, 1113, pp.26-35. ⟨10.1016/j.aca.2020.03.062⟩
Analytica Chimica Acta, 2020, 1113, pp.26-35. ⟨10.1016/j.aca.2020.03.062⟩

Biophysical techniques that enable the screening and identification of weak affinity fragments against a target protein are at the heart of Fragment Based Drug Design approaches. In the case of membrane proteins, the crucial criteria for fragment scr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e5f72c8df6e533962522c677471707
https://hal.archives-ouvertes.fr/hal-03045118/file/Manuscript_auteurs.pdf

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Enabling STD-NMR fragment screening using stabilized native GPCR: A case study of adenosine receptor

Autor: Anass Jawhari, Maciej Baranowski, Olivier Cala, Javier Pérez, Isabelle Krimm, Erika Cecon, Ralf Jockers, Maja Pučić-Baković, Claire Raingeval, Gordan Lauc, Sébastien Igonet

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp. Article Number: 8142 ⟨10.1038/s41598-018-26113-0⟩
Scientific Reports, 2018, 8 (1), pp. Article Number: 8142 ⟨10.1038/s41598-018-26113-0⟩

We thank Emmanuel DEJEAN for continuous support, Kelly GARNIER for help with thermal-shift assay and the CALIXAR team for helpful discussions. We would like to thank Patrick SCHULTZ for initial electron microscopy work and discussions and Alice ROTHN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb399d5b559bb1d1510bedf62019aad4
https://doi.org/10.1038/s41598-018-26113-0

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The Dynamics of Copper Uptake in Human Cu,Zn-Superoxide Dismutase: a Solid-State NMR Study

Autor: Claire Raingeval, Olivier Cala, Béatrice Brion, Isabelle Krimm

Publikováno v: XXIXème congrès du GERM
XXIXème congrès du GERM, Groupement d'études de résonance magnétique, May 2017, Aussois, France
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http://thcgerm.free.fr/spip.php?article123; National audience; Les expériences de saturation transfer difference (STD) et de Water–ligand observed via gradient spectroscopy (WaterLOGSY) sont des techniques simples et rapides de criblage, largement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::aab551d8adce6853f5694638ec36efd4
https://hal.archives-ouvertes.fr/hal-01865374

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