Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Claire R. Hatty"'
Autor:
Claire R. Hatty, Ryan J. Middleton, Ronald Chan, Richard B. Banati, Winnie Wai-Ying Kam, Guo Jun Liu, David Y. Chin
Publikováno v:
Cell Cycle
Recent loss-of-function studies in tissue-specific as well as global Tspo (Translocator Protein 18 kDa) knockout mice have not confirmed its long assumed indispensability for the translocation of cholesterol across the mitochondrial inter-membrane sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4054cc9f422ccf699048cfedebade342
http://europepmc.org/articles/PMC5351937
http://europepmc.org/articles/PMC5351937
Autor:
Richard B. Banati, Claire R. Hatty
Publikováno v:
Pharmacological Research. 100:58-63
The targets of many small molecule drugs are membrane proteins, and traditionally the focus of pharmacology is on the interaction between such receptors and their small molecule drug ligands. However, the lipid membranes of cells and organelles are i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23085ac975f4ecb8a0accf88205a7bde
https://doi.org/10.1016/j.phrs.2015.07.029
https://doi.org/10.1016/j.phrs.2015.07.029
Autor:
Guo Jun Liu, Tien Pham, Meredith Harrison-Brown, Claire R. Hatty, Ronald Chan, Richard B. Banati, Winnie Wai-Ying Kam, Eoin Dodson, Kelly Veale, Ryan J. Middleton
Publikováno v:
Brain Pathology
The 18 kDa translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor, is expressed in the injured brain. It has become known as an imaging marker of “neuroinflammation” indicating active disease, and is best interpre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b12c6f84c0b6b372342ab9d32b3960
https://doi.org/10.1111/bpa.12196
https://doi.org/10.1111/bpa.12196
Autor:
Anton P. Le Brun, Claire R. Hatty, Vanessa Lake, Luke A. Clifton, Richard B. Banati, Guo Jun Liu, Michael James
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1838:1019-1030
The functional effects of a drug ligand may be due not only to an interaction with its membrane protein target, but also with the surrounding lipid membrane. We have investigated the interaction of a drug ligand, PK11195, with its primary protein tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b5b8fc08054b0bdec7e9949680c7b0
https://doi.org/10.1016/j.bbamem.2013.12.013
https://doi.org/10.1016/j.bbamem.2013.12.013
Autor:
Andrew F. Hill, Deborah J. Tew, Frances Separovic, Martin Boland, Kevin J. Barnham, Steven J. Collins, Cathryn L. Haigh, Michael James, Claire R. Hatty, Colin L. Masters
Publikováno v:
Journal of Biological Chemistry. 285:32282-32292
Although the N terminus of the prion protein (PrP(C)) has been shown to directly associate with lipid membranes, the precise determinants, biophysical basis, and functional implications of such binding, particularly in relation to endogenously occurr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d575fed04eef7f81d5c4bd4b8d195904
https://doi.org/10.1074/jbc.m110.123398
https://doi.org/10.1074/jbc.m110.123398
Autor:
Marie Gregoire, Claire R. Hatty, Tien Pham, Candice Quin, Winnie Wai-Ying Kam, Manuel B. Graeber, Emma Davis, Alexander M Szabo, Nicholas R. Howell, Guo Jun Liu, Sandra Fok, Arvind Parmar, Ryan J. Middleton, Paul D. Callaghan, Ronald Chan, Richard B. Banati, David Zahra
Publikováno v:
Nature Communications
The evolutionarily conserved peripheral benzodiazepine receptor (PBR), or 18-kDa translocator protein (TSPO), is thought to be essential for cholesterol transport and steroidogenesis, and thus life. TSPO has been proposed as a biomarker of neuroinfla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ddc3858653b6e4054958925889ffaf
https://doi.org/10.1038/ncomms6452
https://doi.org/10.1038/ncomms6452