CSIG-20. L3MBTL3 SUPPRESSES MEDULLOBLASTOMA TUMORIGENESIS THROUGH MODULATION OF THE NOTCH/RBPJ SIGNALING PATHWAY

Autor: Rashmi Budhathoki, Claire Peabody, Sandra Camelo-Piragua, Thomas L. Saunders, Philip Chi-En Huang, Ester Calvo Fernandez, Tao Xu, Elizabeth D. Hughes, Brian Magnuson, Jean François Rual, Rork Kuick, Honglai Zhang

Publikováno v: Neuro Oncol

The NOTCH/RBPJ pathway governs cell proliferation in many biological contexts, including SHH and Group#3medulloblastoma (MB) tumorigenesis. Using our proteomic platform, we discovered an interaction between RBPJ, a key co-factor of NOTCH for the modu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e110b90a2bf30a695d79ba08dcdc5c
https://europepmc.org/articles/PMC7650321/

Loss of AMPKα2 Impairs Hedgehog-Driven Medulloblastoma Tumorigenesis

Autor: Justin Yoon, Dafydd G. Thomas, Ester Calvo Fernandez, Sandra Camelo-Piragua, Ken Inoki, Jean François Rual, Junying Wang, Claire Peabody, Rork Kuick, Sung Soo Park, Benoit Viollet, Honglai Zhang

Publikováno v: International Journal of Molecular Sciences
Volume 19
Issue 11
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3287 (2018)
International Journal of Molecular Sciences, MDPI, 2018, 19 (11), pp.3287. ⟨10.3390/ijms19113287⟩
International Journal of Molecular Sciences, 2018, 19 (11), pp.3287. ⟨10.3390/ijms19113287⟩

The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status that has a dual role in cancer, i.e., pro- or anti-tumorigenic, depending on the context. In medulloblastoma, the most frequent malignant pediatric brain tumor, several in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9f14fea5631b41a701906562e3a44f
http://europepmc.org/articles/PMC6274763