Generation of a Novel In Vitro Model to Study Endothelial Dysfunction from Atherothrombotic Specimens

Autor: Erika Zodda, Mairi Brittan, Takeshi Fujisawa, Andrew Mitchell, Claire N. Medine, John Hung, Patrick W. F. Hadoke, Nicholas L. Mills, Olga Tura-Ceide, Marta Cascante, Neus Luque, Elizabeth M. Skinner, S. Gallogly

Publikováno v: Cardiovascular Drugs and Therapy
Gallogly, S, Fujisawa, T, Hung, J D, Brittan, M, Skinner, E M, Mitchell, A J, Medine, C, Luque, N, Zodda, E, Cascante, M, Hadoke, P W, Mills, N L & Tura-Ceide, O 2021, ' Generation of a Novel In Vitro Model to Study Endothelial Dysfunction from Atherothrombotic Specimens ', Cardiovascular Drugs and Therapy . https://doi.org/10.1007/s10557-021-07151-9

Purpose Endothelial dysfunction is central to the pathogenesis of acute coronary syndrome. The study of diseased endothelium is very challenging due to inherent difficulties in isolating endothelial cells from the coronary vascular bed. We sought to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d115232eb38db4843d892093f555903
https://pubmed.ncbi.nlm.nih.gov/33608862

Sodium channel current loss of function in induced pluripotent stem cell-derived cardiomyocytes from a Brugada syndrome patient

Autor: Elisabet, Selga, Franziska, Sendfeld, Rebecca, Martinez-Moreno, Claire N, Medine, Olga, Tura-Ceide, Sir Ian, Wilmut, Guillermo J, Pérez, Fabiana S, Scornik, Ramon, Brugada, Nicholas L, Mills

Publikováno v: Journal of Molecular and Cellular Cardiology

Brugada syndrome predisposes to sudden death due to disruption of normal cardiac ion channel function, yet our understanding of the underlying cellular mechanisms is incomplete. Commonly used heterologous expression models lack many characteristics o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6499a9099d46731260dedb3faebaacfd
https://pubmed.ncbi.nlm.nih.gov/29024690

Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism

Autor: Zara Hannoun, Claire N. Medine, Sebastian Greenhough, John P. Iredale, Salvatore Pernagallo, Mark Bradley, James A. Ross, Judy Fletcher, James R. Black, Alexandra I. Thompson, Juan J. Díaz-Mochón, Donna Dalgetty, Joerg Schrader, Stuart J. Forbes, David C. Hay, Philip N. Newsome

Publikováno v: Stem Cell Research. 6(2):92-102

Maintaining stable differentiated somatic cell function in culture is essential to a range of biological endeavors. However, current technologies, employing, for example, primary hepatic cell culture (essential to the development of a bio-artificial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9017e6c999f57faa2ba90afcc1f70b

Pluripotent stem cell derived hepatocyte like cells and their potential in toxicity screening

Autor: David C. Hay, Sebastian Greenhough, Claire N. Medine

Publikováno v: Toxicology. 278:250-255

Despite considerable progress in modelling human liver toxicity, the requirement still exists for efficient, predictive and cost effective in vitro models to reduce attrition during drug development. Thousands of compounds fail in this process, with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d534be730a27ff633f6e40a84b2ffa22
https://doi.org/10.1016/j.tox.2010.07.012

230 Tracking late outgrowth endothelial cells in an acute arterial injury model

Autor: Adriana Tavares, Andrew Mitchell, Patrick W. F. Hadoke, Nicholas L. Mills, Claire N. Medine, Takeshi Fujisawa, Carlos Alcaide Corral

Publikováno v: Heart. 103:A148.1-A148

Aim Late outgrowth endothelial cells (EOC) are strong contenders to be the true circulating endothelial progenitor cells since they are capable of clonogenic expansion, exhibit a mature endothelial phenotype, and contribute to angiogenesis in vivo .

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26297b9e156b325406fbcfd7a63d4404
https://doi.org/10.1136/heartjnl-2017-311726.228