Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Claire N. Bedbrook"'
Publikováno v:
eLife, Vol 12 (2023)
The African turquoise killifish is a powerful vertebrate system to study complex phenotypes at scale, including aging and age-related disease. Here, we develop a rapid and precise CRISPR/Cas9-mediated knock-in approach in the killifish. We show its e
Externí odkaz:
https://doaj.org/article/69dfcd8724af4134a1451a89d5dbaca8
Autor:
Andrew McKay, Emma K Costa, Jingxun Chen, Chi-Kuo Hu, Xiaoshan Chen, Claire N Bedbrook, Rishad C Khondker, Mike Thielvoldt, Param Priya Singh, Tony Wyss-Coray, Anne Brunet
Publikováno v:
eLife, Vol 11 (2022)
The African turquoise killifish is an exciting new vertebrate model for aging studies. A significant challenge for any model organism is the control over its diet in space and time. To address this challenge, we created an automated and networked fis
Externí odkaz:
https://doaj.org/article/21efc0fc55a84b2998c5672deb075de3
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 10, p e1005786 (2017)
There is growing interest in studying and engineering integral membrane proteins (MPs) that play key roles in sensing and regulating cellular response to diverse external signals. A MP must be expressed, correctly inserted and folded in a lipid bilay
Externí odkaz:
https://doaj.org/article/c7990023d07d4d19b4924dbd81505cb9
Autor:
Jingxun Chen, Emma K Costa, Andrew McKay, Chi-Kuo Hu, Xiaoshan Chen, Claire N Bedbrook, Rishad C Khondker, Mike Thielvoldt, Param Priya Singh, Tony Wyss-Coray, Anne Brunet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a48b48f2db46f5773de081a161f97286
https://doi.org/10.7554/elife.69008.sa2
https://doi.org/10.7554/elife.69008.sa2
The African turquoise killifish is a powerful vertebrate system to study complex phenotypes at scale, including aging and age-related disease. Here we develop a rapid and precise CRISPR/Cas9-mediated knock-in approach in the killifish. We show its ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fd03fa96553fb6ec6bb86c82f03e50
https://doi.org/10.1101/2022.05.25.493454
https://doi.org/10.1101/2022.05.25.493454
Autor:
Kevin K. Yang, Elisha D.W. Mackey, Claire N. Bedbrook, Frances H. Arnold, J. Elliott Robinson, Viviana Gradinaru
Publikováno v:
Nature methods
We engineered light-gated channelrhodopsins (ChRs) whose current strength and light sensitivity enable minimally-invasive neuronal circuit interrogation. Current ChR tools applied to the mammalian brain require intracranial surgery for transgene deli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35fb8ae69d0952ca89ebd8d118a7c1a
https://doi.org/10.1038/s41592-019-0583-8
https://doi.org/10.1038/s41592-019-0583-8
Autor:
Andrew McKay, Emma K. Costa, Jingxun Chen, Chi-Kuo Hu, Xiaoshan Chen, Claire N. Bedbrook, Rishad C. Khondker, Mike Thielvoldt, Param Priya Singh, Tony Wyss-Coray, Anne Brunet
The African turquoise killifish is an exciting new vertebrate model for aging studies. A significant challenge for any model organism is the control over its diet in space and time. To address this challenge, we created an automated and networked fis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d58e25a14bdc766cdaa3910f18ea6b6a
https://doi.org/10.1101/2021.03.30.437790
https://doi.org/10.1101/2021.03.30.437790
Autor:
Jingxun Chen, Emma K Costa, Andrew McKay, Chi-Kuo Hu, Xiaoshan Chen, Claire N Bedbrook, Rishad C Khondker, Mike Thielvoldt, Param Priya Singh, Tony Wyss-Coray, Anne Brunet
Publikováno v:
eLife. 11
The African turquoise killifish is an exciting new vertebrate model for aging studies. A significant challenge for any model organism is the control over its diet in space and time. To address this challenge, we created an automated and networked fis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26848a270a63c0bfe91be83c8b367292
https://pubmed.ncbi.nlm.nih.gov/36354233
https://pubmed.ncbi.nlm.nih.gov/36354233
Publikováno v:
Annual Review of Neuroscience. 41:323-348
Recombinant viruses allow for targeted transgene expression in specific cell populations throughout the nervous system. The adeno-associated virus (AAV) is among the most commonly used viruses for neuroscience research. Recombinant AAVs (rAAVs) are h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ec6acecf857a90c37aa03a81121cc4
https://doi.org/10.1146/annurev-neuro-080317-062048
https://doi.org/10.1146/annurev-neuro-080317-062048