Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Claire McGready"'
Autor:
Mark Southwood, Tomasz Krenz, Natasha Cant, Manisha Maurya, Jana Gazdova, Perry Maxwell, Claire McGready, Ellen Moseley, Susan Hughes, Peter Stewart, Manuel Salto‐Tellez, Daniel Groelz, Doris Rassl, On behalf of the STRATfix Consortium
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 6, Iss 1, Pp 40-54 (2020)
Abstract Whilst adequate for most existing pathological tests, formalin is generally considered a poor DNA preservative and use of alternative fixatives may prove advantageous for molecular testing of tumour material; an increasingly common approach
Externí odkaz:
https://doaj.org/article/a9d620a0402d45b48de3ed93c2c95d54
Autor:
Mark Southwood, Tomasz Krenz, Natasha Cant, Manisha Maurya, Jana Gazdova, Perry Maxwell, Claire McGready, Ellen Moseley, Susan Hughes, Peter Stewart, Manuel Salto‐Tellez, Daniel Groelz, Doris Rassl, On behalf of the STRATfix Consortium
Publikováno v:
The Journal of Pathology: Clinical Research
Southwood, M, Krenz, T, Cant, N, Maurya, M, Gazdova, J, Maxwell, P, McGready, C, Moseley, E, Hughes, S, Stewart, P, Salto-Tellez, M, Groelz, D & Rassl, D 2020, ' Systematic evaluation of PAXgene® tissue fixation for the histopathological and molecular study of lung cancer ', The Journal of Pathology: Clinical Research, vol. 6, no. 1, pp. 40-54 . https://doi.org/10.1002/cjp2.145, https://doi.org/10.1002/cjp2.145
The Journal of Pathology: Clinical Research, Vol 6, Iss 1, Pp 40-54 (2020)
Southwood, M, Krenz, T, Cant, N, Maurya, M, Gazdova, J, Maxwell, P, McGready, C, Moseley, E, Hughes, S, Stewart, P, Salto-Tellez, M, Groelz, D & Rassl, D 2020, ' Systematic evaluation of PAXgene® tissue fixation for the histopathological and molecular study of lung cancer ', The Journal of Pathology: Clinical Research, vol. 6, no. 1, pp. 40-54 . https://doi.org/10.1002/cjp2.145, https://doi.org/10.1002/cjp2.145
The Journal of Pathology: Clinical Research, Vol 6, Iss 1, Pp 40-54 (2020)
Whilst adequate for most existing pathological tests, formalin is generally considered a poor DNA preservative and use of alternative fixatives may prove advantageous for molecular testing of tumour material; an increasingly common approach to identi
Autor:
Jacqueline A James, Stephen McQuaid, Matthew P. Humphries, Manuel Salto-Tellez, Stephanie G Craig, Jason McGrath, Maurice B Loughrey, Victoria Bingham, Peter Bankhead, Helen G Coleman, Claire McGready, Perry Maxwell
Publikováno v:
Loughrey, M B, Mcgrath, J, Coleman, H G, Bankhead, P, Maxwell, P, Mcgready, C, Bingham, V, Humphries, M P, Craig, S G, Mcquaid, S, Salto-tellez, M & James, J A 2020, ' Identifying mismatch repair deficient colon cancer: near perfect concordance between immunohistochemistry and microsatellite instability testing in a large, population-based series ', Histopathology . https://doi.org/10.1111/his.14233
Loughrey, M B, McGrath, J, Coleman, H G, Bankhead, P, Maxwell, P, McGready, C, Bingham, V, Humphries, M P, Craig, S G, McQuaid, S, Salto-Tellez, M & James, J A 2021, ' Identifying mismatch repair deficient colon cancer near perfect concordance between immunohistochemistry and microsatellite instability testing in a large, population-based series ', Histopathology, vol. 78, no. 3, pp. 401-413 . https://doi.org/10.1111/his.14233
Loughrey, M B, McGrath, J, Coleman, H G, Bankhead, P, Maxwell, P, McGready, C, Bingham, V, Humphries, M P, Craig, S G, McQuaid, S, Salto-Tellez, M & James, J A 2021, ' Identifying mismatch repair deficient colon cancer near perfect concordance between immunohistochemistry and microsatellite instability testing in a large, population-based series ', Histopathology, vol. 78, no. 3, pp. 401-413 . https://doi.org/10.1111/his.14233
AIMS Establishing the mismatch repair (MMR) status of colorectal cancers is important to enable the detection of underlying Lynch syndrome and inform prognosis and therapy. Current testing typically involves either polymerase chain reaction (PCR)-bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d9038964f220ffdf79c5a52da4dfed
https://hdl.handle.net/20.500.11820/43fa8fcc-9183-4d27-b914-40d3f6ff3b66
https://hdl.handle.net/20.500.11820/43fa8fcc-9183-4d27-b914-40d3f6ff3b66
Autor:
Jacqueline James, Stephanie G Craig, Stephen McQuaid, Fiona McLean, Perry Maxwell, Claire McGready, Marc Fuchs, Manuel Salto-Tellez, Sean O. Hynes
Publikováno v:
Journal of Clinical Pathology. 72:225-231
AimsAlthough there have been excellent reports in the literature of validating next-generation sequencing, comparisons between two systems are not often published due to cost and time. We set out to establish that targetable mutations could be reliab
Autor:
Perry Maxwell, Wendy Moore, Victoria Bingham, Brendan Pang, Richard H. Wilson, Marc-Aurel Fuchs, Muhammad A Alvi, Graeme I. Murray, Maurice B Loughrey, Manuel Salto-Tellez, Stephen McQuaid, Philip D Dunne, Mark Lawler, Claire McGready, Richard C. Turkington, Jacqueline James
Publikováno v:
British Journal of Cancer
Alvi, M, Loughrey, M B, Dunne, P, McQuaid, S, Turkington, R, Fuchs, M-A, McGready, C, Bingham, V, Moore, W, Lawler, M, James, J A, Murray, G I, Wilson, R H, Maxwell, P & Salto-Tellez, M 2017, ' Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies ', British Journal of Cancer, vol. 117, no. 2, pp. 203-209 . https://doi.org/10.1038/bjc.2017.168, https://doi.org/10.1038/bjc.2017.168
Alvi, M, Loughrey, M B, Dunne, P, McQuaid, S, Turkington, R, Fuchs, M-A, McGready, C, Bingham, V, Moore, W, Lawler, M, James, J A, Murray, G I, Wilson, R H, Maxwell, P & Salto-Tellez, M 2017, ' Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies ', British Journal of Cancer, vol. 117, no. 2, pp. 203-209 . https://doi.org/10.1038/bjc.2017.168, https://doi.org/10.1038/bjc.2017.168
BACKGROUNDSignet ring cell colorectal cancer (SRCCa) has a bleak prognosis. Employing molecular pathology techniques we investigated the potential of precision medicine in this disease.METHODSUsing test (n=26) and validation (n=18) cohorts, analysis
Autor:
Richard C. Turkington, Maurice B. Loughrey, Perry Maxwell, Richard H. Wilson, Claire McGready, Victoria Bingham, Stephen McQuaid, Peter W. Hamilton, Darragh G. McArt, Jacqueline James, Paul J Kelly, Manuel Salto-Tellez, Muhammad A Alvi, Frank Emmert-Streib, Matthew Alderdice, Marc-Aurel Fuchs, Shailesh Tripathi, Clare M. McCabe
Publikováno v:
Alvi, M A, McArt, D G, Kelly, P, Fuchs, M-A, Alderdice, M, McCabe, C M, Bingham, V, McGready, C, Tripathi, S, Emmert-Streib, F, Loughrey, M B, McQuaid, S, Maxwell, P, Hamilton, P W, Turkington, R, James, J A, Wilson, R H & Salto-Tellez, M 2015, ' Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility ', Oncotarget, vol. 6, no. 25, pp. 20863-74 . https://doi.org/10.18632/oncotarget.4576
Oncotarget
Tampere University
ResearcherID
Oncotarget
Tampere University
ResearcherID
Small bowel accounts for only 0.5% of cancer cases in the US but incidence rates have been rising at 2.4% per year over the past decade. One-third of these are adenocarcinomas but little is known about their molecular pathology and no molecular marke
Autor:
Helen G. Coleman, Liam J. Murray, Roisin O'Neill, Maurice B Loughrey, Peter Bankhead, Anna Gavin, Christopher Cardwell, Jacqueline James, Claire McGready, Kenneth Arthur, Ronan T. Gray, Victoria Bingham, Peter W. Hamilton, Manuel Salto-Tellez, Stephen McQuaid
Publikováno v:
Gray, R T, Loughrey, M B, Bankhead, P, Cardwell, C R, McQuaid, S, O'Neill, R F, Arthur, K, Bingham, V, McGready, C, Gavin, A T, James, J A, Hamilton, P W, Salto-Tellez, M, Murray, L J & Coleman, H G 2017, ' Statin use, Candidate Mevalonate Pathway Biomarkers, and Colon Cancer Survival in a Population-Based Cohort Study ', British Journal of Cancer, vol. 152, no. 5, pp. S1023-S1024 . https://doi.org/10.1038/bjc.2017.139
Gray, R T, Loughrey, M B, Bankhead, P, Cardwell, C R, McQuaid, S, O'Neill, R F, Arthur, K, Bingham, V, McGready, C, Gavin, A T, James, J A, Hamilton, P W, Salto-Tellez, M, Murray, L J & Coleman, H G 2017, ' Statin use, candidate mevalonate pathway biomarkers, and colon cancer survival in a population-based cohort study ', British Journal of Cancer, vol. 116, no. 12, pp. 1652-1659 . https://doi.org/10.1038/bjc.2017.139
British Journal of Cancer
Gray, R T, Loughrey, M B, Bankhead, P, Cardwell, C R, McQuaid, S, O'Neill, R F, Arthur, K, Bingham, V, McGready, C, Gavin, A T, James, J A, Hamilton, P W, Salto-Tellez, M, Murray, L J & Coleman, H G 2017, ' Statin use, candidate mevalonate pathway biomarkers, and colon cancer survival in a population-based cohort study ', British Journal of Cancer, vol. 116, no. 12, pp. 1652-1659 . https://doi.org/10.1038/bjc.2017.139
British Journal of Cancer
BACKGROUND: Statin use after colorectal cancer diagnosis may improve survival but evidence from observational studies is conflicting. The anti-cancer effect of statins may be restricted to certain molecular subgroups. In this population-based cohort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18dfe1316c6acbedd5c86928c235e717
https://pure.qub.ac.uk/en/publications/statin-use-candidate-mevalonate-pathway-biomarkers-and-colon-cancer-survival-in-a-populationbased-cohort-study(7d6339ef-8a58-4300-a4f0-efa728cd5b0e).html
https://pure.qub.ac.uk/en/publications/statin-use-candidate-mevalonate-pathway-biomarkers-and-colon-cancer-survival-in-a-populationbased-cohort-study(7d6339ef-8a58-4300-a4f0-efa728cd5b0e).html
Autor:
Philip D Dunne, Stephen McQuaid, Helen G. Coleman, Claire McGready, Ronan T. Gray, Paul J Kelly, Maurice B Loughrey, Sean O. Hynes, Steven Irwin, Manuel Salto-Tellez, Roisin O'Neill, Jacqueline James
Publikováno v:
Hynes, S O, Coleman, H G, Kelly, P J, Irwin, S, O'Neill, R F, Gray, R T, McGready, C, Dunne, P D, McQuaid, S, James, J A, Salto-Tellez, M & Loughrey, M B 2017, ' Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study ', Histopathology . https://doi.org/10.1111/his.13181
AimsBoth morphological and molecular approaches have highlighted the biological and prognostic importance of the tumour microenvironment in colorectal cancer (CRC). Despite this, microscopic assessment of tumour microenvironment has not been adopted
Autor:
Christopher Cardwell, Brian T. Johnston, Marie M. Cantwell, Peter Bankhead, Peter W. Hamilton, Manuel Salto-Tellez, Jacqueline James, Stephen McQuaid, Maurice B Loughrey, Kenneth Arthur, Liam J. Murray, Roisin O'Neill, Ronan T. Gray, Anna Gavin, Victoria Bingham, Helen G. Coleman, Claire McGready
Publikováno v:
Gray, R T, Cantwell, M M, Coleman, H G, Loughrey, M B, Bankhead, P, McQuaid, S, O'Neill, R F, Arthur, K, Bingham, V, McGready, C, Gavin, A T, Cardwell, C R, Johnston, B T, James, J A, Hamilton, P W, Salto-Tellez, M & Murray, L J 2017, ' Evaluation of PTGS2 Expression, PIK3CA Mutation, Aspirin Use and Colon Cancer Survival in a Population-Based Cohort Study ', Clinical and translational gastroenterology, vol. 8, no. 4, pp. e91 . https://doi.org/10.1038/ctg.2017.18
Clinical and Translational Gastroenterology
Gray, R T, Cantwell, M M, Coleman, H G, Loughrey, M B, Bankhead, P, McQuaid, S, O'Neill, R F, Arthur, K, Bingham, V, McGready, C, Gavin, A T, Cardwell, C R, Johnston, B T, James, J A, Hamilton, P W, Salto-Tellez, M & Murray, L J 2017, ' Evaluation of PTGS2 expression, PIK3CA mutation, aspirin use and colon cancer survival in a population-based cohort study. ', Clinical and translational gastroenterology, vol. 8, e91 . https://doi.org/10.1038/ctg.2017.18
Clinical and Translational Gastroenterology
Gray, R T, Cantwell, M M, Coleman, H G, Loughrey, M B, Bankhead, P, McQuaid, S, O'Neill, R F, Arthur, K, Bingham, V, McGready, C, Gavin, A T, Cardwell, C R, Johnston, B T, James, J A, Hamilton, P W, Salto-Tellez, M & Murray, L J 2017, ' Evaluation of PTGS2 expression, PIK3CA mutation, aspirin use and colon cancer survival in a population-based cohort study. ', Clinical and translational gastroenterology, vol. 8, e91 . https://doi.org/10.1038/ctg.2017.18
Objectives: The association between aspirin use and improved survival after colorectal cancer diagnosis may be more pronounced in tumors that have PIK3CA mutations or high PTGS2 expression. However, the evidence of a difference in association by biom
Autor:
Richard H. Wilson, Clare M. McCabe, Darragh G. McArt, Matthew Alderdice, Jacqueline James, Paul J Kelly, Peter W. Hamilton, Marc-Aurel Fuchs, Victoria Bingham, Claire McGready, Stephen McQuaid, Muhammad A Alvi, Manuel Salto-Tellez, Perry Maxwell
Publikováno v:
Cancer Research. 75:4792-4792
Small bowel accounts for only 0.5% of cancer cases in the US; a third of which are adenocarcinomas. But incidence rates have been rising at a rate of 2.4% per year over the last decade. Because of the rarity of this cancer, little is known about its