Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Claire M. Dubois"'
Autor:
Mégane Lebel, Dominic O. Cliche, Martine Charbonneau, Karine Brochu-Gaudreau, Damien Adam, Emmanuelle Brochiero, Claire M. Dubois, André M. Cantin
Publikováno v:
Cells, Vol 13, Iss 13, p 1152 (2024)
Lung parenchymal hypoxia has emerged as a cardinal feature of idiopathic pulmonary fibrosis (IPF). Hypoxia promotes cancer cell invasion and metastasis through signaling that is dependent upon the lysophosphatidic acid (LPA) receptor, LPA1 (LPAR1). A
Externí odkaz:
https://doaj.org/article/cd93b8d8fc104ea49e915025e9fd9228
Autor:
Martine Charbonneau, Kelly Harper, Karine Brochu-Gaudreau, Alexis Perreault, Patrick P. McDonald, Nadia Ekindi-Ndongo, Claudio Jeldres, Claire M. Dubois
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Clear cell renal cell carcinoma (ccRCC) is an aggressive subtype of renal cell carcinoma accounting for the majority of deaths in kidney cancer patients. Advanced ccRCC has a high mortality rate as most patients progress and develop resistance to cur
Externí odkaz:
https://doaj.org/article/d5aaa13b3a744f81922eb52fa8b94ccd
Autor:
María José Hurtado Gutiérrez, Frédérick L. Allard, Hugo Tshivuadi Mosha, Claire M. Dubois, Patrick P. McDonald
Publikováno v:
Cells, Vol 12, Iss 1, p 136 (2022)
Neutrophils influence innate and adaptive immunity by releasing various cytokines and chemokines, by generating neutrophil extracellular traps (NETs), and by modulating their own survival. Neutrophils also produce extracellular vesicles (EVs) termed
Externí odkaz:
https://doaj.org/article/ffcb1e44c2224971b4bde1a89bc61cd8
Autor:
Olga Tatsiy, Thomas Z. Mayer, Vanessa de Carvalho Oliveira, Stéphanie Sylvain-Prévost, Marilyn Isabel, Claire M. Dubois, Patrick P. McDonald
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Gout is a prevalent and incapacitating disease triggered by the deposition of monosodium urate (MSU) crystals in joints, which are also massively infiltrated by neutrophils. The interaction of the latter with MSU crystals triggers several responses,
Externí odkaz:
https://doaj.org/article/6f8f001067ad47a9bf1cb3fb93f393f3
Autor:
Fabrice Lucien, Pierre-Paul Pelletier, Roxane R. Lavoie, Jean-Michel Lacroix, Sébastien Roy, Jean-Luc Parent, Dominique Arsenault, Kelly Harper, Claire M. Dubois
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Sodium/proton exchangers (NHEs) are critical regulators of pH within the cell and the extracellular microenvironment. Here, the authors show that hypoxia induces mobilization of NHE6 from endosomal compartment to the plasma membrane in a PKC-dependen
Externí odkaz:
https://doaj.org/article/e89f4976e6c8410083340eff97f54108
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)
Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistanc
Externí odkaz:
https://doaj.org/article/f277f12eceac40dbb32f7b5a70b904c8
Autor:
Alexis Perreault, Kelly Harper, Mégane Lebel, Martine Charbonneau, Damien Adam, Emmanuelle Brochiero, André M. Cantin, Martin Leduc, Lyne Gagnon, Claire M. Dubois
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:164-172
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cb457a1564e5655cd2ef62856eddccb
https://doi.org/10.1165/rcmb.2022-0037ma
https://doi.org/10.1165/rcmb.2022-0037ma
Autor:
Claire M. Dubois, Karine Brochu-Gaudreau, Martine Charbonneau, Roxane R. Lavoie, Kelly Harper
Hypoxia, a common feature of solid tumors, has been critically involved in cell invasion and metastasis, but the underlying mechanisms remain poorly understood. Previously, it has been observed that the lysophosphatidic acid receptor 4 (LPA4) signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c32d2b3286c153b154452e18f3ef6d1
https://doi.org/10.1158/1541-7786.c.6541213
https://doi.org/10.1158/1541-7786.c.6541213
Autor:
Claire M. Dubois, Karine Brochu-Gaudreau, Martine Charbonneau, Roxane R. Lavoie, Kelly Harper
Figure S1 shows qPCR assessment of LPA receptors knockdown Figure S2 shows EGFR transactivation by LPA1 in various cell lines. Figure S3 shows qPCR assessment of EGFR knockdown in HT1080 cells. Figure S4 shows that Src inhibition blocks EGFR phosphor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d674556d02ecb55a8d848e9181deac
https://doi.org/10.1158/1541-7786.22515892.v1
https://doi.org/10.1158/1541-7786.22515892.v1
Autor:
Claire M. Dubois, Fabrice Lucien, Annie Lauzier, Stephanie Boulay-Jean, Dominique Arsenault, Kelly Harper
Supplementary Figure Legends 1-3, Methods from Autotaxin Promotes Cancer Invasion via the Lysophosphatidic Acid Receptor 4: Participation of the Cyclic AMP/EPAC/Rac1 Signaling Pathway in Invadopodia Formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0782a33d39028debbea8916a1571fe39
https://doi.org/10.1158/0008-5472.22382891
https://doi.org/10.1158/0008-5472.22382891