Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Claire M. Bolton"'
Autor:
Damien Fraysse, Peter Chiu, Philip N. Collier, Heather Twin, Luca Settimo, Francoise Pierard, Dean Boyall, Shazia Keily, Claire M. Bolton, Christopher John Davis, Guy Brenchley, Adam P. Curnock, Jaclyn Henderson, Adam Tanner, Juan-Miguel Jimenez, Andrew Miller, Stephen Clinton Young
Publikováno v:
Journal of medicinal chemistry. 56(5)
Protein kinase C θ (PKCθ) has a central role in T cell activation and survival; however, the dependency of T cell responses to the inhibition of this enzyme appears to be dictated by the nature of the antigen and by the inflammatory environment. St
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18d0371ff520503045d7d7722ddbc9b
https://pubmed.ncbi.nlm.nih.gov/23442161
https://pubmed.ncbi.nlm.nih.gov/23442161
Autor:
Ronald Knegtel, Ian Ager, Luca Settimo, Stephen Clinton Young, Dean Boyall, Richele K Rasmussen, Claire M. Bolton, Peter Chiu, Adam P. Curnock, Christopher John Davis, Adam Tanner, Juan-Miguel Jimenez, Damien Fraysse
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(14)
The identification of a novel series of PKCθ inhibitors and subsequent optimization using docking based on a crystal structure of PKCθ is described. SAR was rapidly generated around an amino pyridine-ketone hit; (6-aminopyridin-2-yl)(2-aminopyridin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dcb8517f1186f9dfe4bbe54db055a35
https://pubmed.ncbi.nlm.nih.gov/22738630
https://pubmed.ncbi.nlm.nih.gov/22738630