Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Claire M Brown"'
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 7, p e1006303 (2018)
Focal adhesions are protein complexes that anchor cells to the extracellular matrix. During migration, the growth and disassembly of these structures are spatiotemporally regulated, with new adhesions forming at the leading edge of the cell and matur
Externí odkaz:
https://doaj.org/article/a80ac60a2cea40429410c4495554d434
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract In mesenchymal cell motility, several migration patterns have been observed, including directional, exploratory and stationary. Two key members of the Rho-family of GTPases, Rac and Rho, along with an adaptor protein called paxillin, have be
Externí odkaz:
https://doaj.org/article/d8e51d04514147abadb126987b2ca006
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Epithelial cells that organise into structures that contain a lumen are polarised. Here, the authors show that the short intracellular domain of transmembrane protein CD13 is required to capture endosomes at the apical site and is required for the po
Externí odkaz:
https://doaj.org/article/036f5b17608448fa948f9d7a338d3066
Autor:
Kyle Lewis, Alex Kiepas, Jesse Hudson, Julien Senecal, Jacqueline R. Ha, Elena Voorand, Matthew G. Annis, Valerie Sabourin, Ryuhjin Ahn, Rachel La Selva, Sébastien Tabariès, Brian E. Hsu, Matthew J. Siegel, Matthew Dankner, Eduardo Cepeda Canedo, Mathieu Lajoie, Ian R. Watson, Claire M. Brown, Peter M. Siegel, Josie Ursini-Siegel
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-19 (2020)
Abstract Background The p66ShcA redox protein is the longest isoform of the Shc1 gene and is variably expressed in breast cancers. In response to a variety of stress stimuli, p66ShcA becomes phosphorylated on serine 36, which allows it to translocate
Externí odkaz:
https://doaj.org/article/3438a5e4c9ae4d46bf14a48ac898942d
Autor:
Benjamin Abrams, Thomas Pengo, Tse-Luen Wee, Rebecca C Deagle, Nelly Vuillemin, Linda M Callahan, Megan A Smith, Kristopher E Kubow, Anne-Marie Girard, Joshua Z Rappoport, Carol J Bayles, Lisa A Cameron, Richard Cole, Claire M Brown
Publikováno v:
Microscopy and Microanalysis. 29:616-634
This article outlines a global study conducted by the Association of Biomedical Resource Facilities (ABRF) Light Microscopy Research Group (LMRG). The results present a novel 3D tissue-like biologically relevant standard sample that is affordable and
Autor:
Bojing Jia, Tse-Luen (Erika) Wee, Colton G. Boudreau, Daniel J. Berard, Adiel Mallik, David Juncker, Claire M. Brown, Sabrina R. Leslie
Publikováno v:
BioTechniques, Vol 61, Iss 2, Pp 73-82 (2016)
Here we present a high-throughput, parallelized cytoindentor for local compression of live cells. The cytoindentor uses convex lens–induced confinement (CLiC) to indent micrometer-sized areas in single cells and/or populations of cells with submicr
Externí odkaz:
https://doaj.org/article/04ae1cb635d94daebc5520b00fded1bb
Autor:
Maximiliaan Huisman, James J. Chambers, Alex Laude, Peter Bajcsy, Ulrike Boehm, Caterina Strambio-De-Castillia, Damir Sudar, Orestis Faklaris, Glyn Nelson, Mathias Hammer, Nathalie Gaudreault, Farzin Farzam, Carlas Smith, Claire M. Brown, Roland Nitschke, Alexander D. Corbett, Judith Lacoste, Jaime A. Pimentel, Alison J. North, Alessandro Rigano, David Grunwald
Publikováno v:
Nat Methods
1 -ABSTRACTDigital light microscopy provides powerful tools for quantitatively probing the real-time dynamics of subcellular structures. While the power of modern microscopy techniques is undeniable, rigorous record-keeping and quality control are re
In mesenchymal cell motility, several migration patterns have been observed, including directional, exploratory and stationary. Two key members of the Rho-family of GTPases, Rac and Rho, along with an adaptor protein called paxillin, have been partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a176ddee47e7f88e4f713fcdaf993939
https://doi.org/10.1101/2022.10.31.514611
https://doi.org/10.1101/2022.10.31.514611
Autor:
Darren Hedley, Ensu Sahin, Mirko Uljarević, Cheryl Dissanayake, Kathleen Denney, Susan M Hayward, Claire M. Brown, Simon M. Bury, Mark A. Stokes, Angela Clapperton, Jo Robinson, Julian N. Trollor
Publikováno v:
Autism Research
The COVID‐19 pandemic has had a significant impact on the mental health and wellbeing of the world's population, with particularly negative effects on vulnerable populations, including autistic people. Although some consensus regarding specific imp
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Polarized epithelial cells can organize into complex structures with a characteristic central lumen. Lumen formation requires that cells coordinately orient their polarity axis so that the basolateral domain is on the outside and apical domain inside