Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Claire Levrier"'
Autor:
Colleen C. Nelson, Rohan A. Davis, Melanie Lehman, Maria Kavallaris, Brian Gabrielli, Anja Rockstroh, Martin C. Sadowski, Claire Levrier
HeLa-H2B-GFP cells were imaged using an Olympus IX81 (1 image/5 min for 24 h). Top panels: brightfield, bottom panels: GFP channel. 6-AA increased in a concentration-dependent manner mitotic duration, leading to cell death or asymmetric division. Sca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d089ae51ff6dd3909643e653283b08c
https://doi.org/10.1158/1535-7163.22507932.v1
https://doi.org/10.1158/1535-7163.22507932.v1
Autor:
Colleen C. Nelson, Rohan A. Davis, Melanie Lehman, Maria Kavallaris, Brian Gabrielli, Anja Rockstroh, Martin C. Sadowski, Claire Levrier
EB1-GFP was imaged by spinning disk microscopy (2 images/s for 2 min). EB1 comets appeared faint and followed irregular and short trajectories. Scale bar=10 µm.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::831c7ac11f465fe682aaac0aaecaff4e
https://doi.org/10.1158/1535-7163.22507923.v1
https://doi.org/10.1158/1535-7163.22507923.v1
Autor:
Colleen C. Nelson, Rohan A. Davis, Melanie Lehman, Maria Kavallaris, Brian Gabrielli, Anja Rockstroh, Martin C. Sadowski, Claire Levrier
Supplementary Figures S1â^'S9 and figures legends Supplementary Tables S1â^'S6 Supplementary Videos S1â^'S5 and legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf5328b8195e9be81dedc8f9b779729
https://doi.org/10.1158/1535-7163.22507938.v1
https://doi.org/10.1158/1535-7163.22507938.v1
Autor:
Colleen C. Nelson, Rohan A. Davis, Melanie Lehman, Maria Kavallaris, Brian Gabrielli, Anja Rockstroh, Martin C. Sadowski, Claire Levrier
EB1-GFP was imaged by spinning disk microscopy (1 image/s for 1 min). EB1 comets were clearly discernible and followed regular trajectories. Scale bar=10 µm.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd291d777196518b32b317141f71c3d1
https://doi.org/10.1158/1535-7163.22507929
https://doi.org/10.1158/1535-7163.22507929
Autor:
Colleen C. Nelson, Rohan A. Davis, Melanie Lehman, Maria Kavallaris, Brian Gabrielli, Anja Rockstroh, Martin C. Sadowski, Claire Levrier
EB1-GFP was imaged by spinning disk microscopy (1 image/s for 1 min). EB1 comets followed irregular and short trajectories. Scale bar=10 µm.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31457681dad027b39c354d6ef6c80ce4
https://doi.org/10.1158/1535-7163.22507926.v1
https://doi.org/10.1158/1535-7163.22507926.v1
Autor:
Colleen C. Nelson, Rohan A. Davis, Melanie Lehman, Maria Kavallaris, Brian Gabrielli, Anja Rockstroh, Martin C. Sadowski, Claire Levrier
HeLa-H2B-GFP cells were imaged using an Olympus IX81 (1 image/5 min for 24 h). Top panels: brightfield, bottom panels: H2B-GFP. DMSO-treated cells normally progressed through mitosis, which was delayed with vinblastine (20 nM) and low dose of 6-AA (0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4995a29e6e6064ad7e156e57e548334e
https://doi.org/10.1158/1535-7163.22507935
https://doi.org/10.1158/1535-7163.22507935
Autor:
Rohan A. Davis, Martin C. Sadowski, Jennifer H. Gunter, Charles L. Bidgood, Rohitesh Kumar, Claire Levrier, Colleen C. Nelson
Publikováno v:
Journal of natural products. 83(8)
The spirooxepinisoxazoline alkaloid psammaplysin F (1) was selected as a scaffold for the generation of a unique screening library for both drug discovery and chemical biology research. Large-scale extraction and isolation chemistry was performed on
Autor:
Martin C. Sadowski, Rohan A. Davis, Melanie Lehman, Claire Levrier, Colleen C. Nelson, Brian Gabrielli, Anja Rockstroh, Maria Kavallaris
Publikováno v:
Cell Cycle
We report for the first time the mechanism of action of the natural product thalicthuberine (TH) in prostate and cervical cancer cells. TH induced a strong accumulation of LNCaP cells in mitosis, severe mitotic spindle defects, and asymmetric cell di
Autor:
H Armstrong, Joanna L. Gillis, Luke A. Selth, Claire Levrier, Zeyad D. Nassar, Martin C. Sadowski, Margaret M. Centenera, Ian R D Johnson, Lisa M. Butler, Gerard A. Tarulli, Emma S. Tomlinson Guns, Douglas A. Brooks, Mei Yieng Chin, David J. Lynn, Max Moldovan
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports
Scientific Reports
The molecular chaperone Hsp90 is overexpressed in prostate cancer (PCa) and is responsible for the folding, stabilization and maturation of multiple oncoproteins, which are implicated in PCa progression. Compared to first-in-class Hsp90 inhibitors su
Autor:
Rohan A. Davis, Claire Levrier, Martin C. Sadowski, Mark J. Coster, Folake A Egbewande, Jonathan M. White, Kaylyn D. Tousignant, Colleen C. Nelson
Publikováno v:
Journal of natural products. 81(4)
The naturally occurring pentacyclic diterpenoid gibberellic acid (1) was used in the generation of a drug-like amide library using parallel-solution-phase synthesis. Prior to the synthesis, a virtual library was generated and prioritized based on dru