Placental syncytins: Genetic disjunction between the fusogenic and immunosuppressive activity of retroviral envelope proteins

Autor: Bertrand Ducos, Odile Heidmann, Marianne Mangeney, Isabelle Bouallaga, Géraldine Schlecht-Louf, Martial Renard, Thierry Heidmann, Aurélien Richaud, Claire Letzelter

Publikováno v: Proceedings of the National Academy of Sciences. 104:20534-20539

We have previously demonstrated that the envelope proteins of a murine and primate retrovirus are immunosuppressive in vivo . This property was manifested by the ability of the proteins, when expressed by allogeneic tumor cells normally rejected by e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50b7041e9bdd0a4df5754c3e0802d76
https://doi.org/10.1073/pnas.0707873105

Captured retroviral envelope syncytin gene associated with the unique placental structure of higher ruminants

Autor: Michel Guillomot, Alexandre Hassanin, Séverine A. Degrelle, Baptiste Mulot, Cécile Vernochet, Anne Dupressoir, Odile Heidmann, Guillaume Cornelis, Sibylle Bernard-Stoecklin, Isabelle Hue, Thierry Heidmann, Claire Letzelter, Christian Lavialle

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2013, 110 (9), pp.E828-E837. ⟨10.1073/pnas.1215787110⟩
Proceedings of the National Academy of Sciences of the United States of America 9 (110), E828-E837. (2013)
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (9), pp.E828-E837. ⟨10.1073/pnas.1215787110⟩

Syncytins are envelope genes of retroviral origin that have been co-opted for a role in placentation and likely contribute to the remarkable diversity of placental structures. Independent capture events have been identified in primates, rodents, lago

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49dc59bd4a00cfc9973ac075b330ac2c
https://www.hal.inserm.fr/inserm-02440372/file/C8_Cornelis_PNAS_2013.pdf

Crystal structure of a pivotal domain of human syncytin-2, A 40 million years old endogenous retrovirus fusogenic envelope gene captured by primates

Autor: Claire Letzelter, Stéphane Duquerroy, Martial Renard, Félix A. Rey, Thierry Heidmann, Paloma F. Varela

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2005, 352 (5), pp.1029-1034

HERV-FRD is a human endogenous retrovirus that entered the human genome 40 million years ago. Its envelope gene, syncytin-2, was diverted by an ancestral host most probably because of its fusogenic property, for a role in placenta morphogenesis. It w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53bd42cfbc1d3ef16a97babea86db2b5
https://hal.inrae.fr/hal-02679639

Captured retroviral envelope syncytin gene associated with the unique placental structure of higher ruminants.

Autor: Cornelis, Guillaume, Heidmann, Odile, Degrelle, Séverine A., Vernochet, Cécile, Lavialle, Christian, Letzelter, Claire, Bernard-Stoecklin, Sibylle, Hassanin, Alexandre, Mulot, Baptiste, Guillomot, Michel, Hue, Isabelle, Heidmann, Thierry, Dupressoir, Anne

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 2/26/2013, Vol. 110 Issue 9, p3227-3228, 2p

L’albero intricato

Autor: David Quammen

A guidare la mano di Darwin mentre nel 1837 tracciava in un taccuino il primo schizzo del suo «albero della vita» c'era l'idea della discendenza delle specie da un antenato comune. Idea audace, che andava contro il dogma creazionista e stabiliva un