Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Claire Le Manach"'
Autor:
Janette Reader, Mariëtte E. van der Watt, Dale Taylor, Claire Le Manach, Nimisha Mittal, Sabine Ottilie, Anjo Theron, Phanankosi Moyo, Erica Erlank, Luisa Nardini, Nelius Venter, Sonja Lauterbach, Belinda Bezuidenhout, Andre Horatscheck, Ashleigh van Heerden, Natalie J. Spillman, Anne N. Cowell, Jessica Connacher, Daniel Opperman, Lindsey M. Orchard, Manuel Llinás, Eva S. Istvan, Daniel E. Goldberg, Grant A. Boyle, David Calvo, Dalu Mancama, Theresa L. Coetzer, Elizabeth A. Winzeler, James Duffy, Lizette L. Koekemoer, Gregory Basarab, Kelly Chibale, Lyn-Marié Birkholtz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Here, Reader et al. screen the Medicines for Malaria Venture Pandemic Response Box in parallel against Plasmodiumasexual and liver stage parasites, stage IV/V gametocytes, gametes, oocysts and as endectocides. They identify two potent transmission-bl
Externí odkaz:
https://doaj.org/article/469ad5b32c23403795a07ad1d5fdbabe
Autor:
Theresa L. Coetzer, Lizette L. Koekemoer, Elizabeth A. Winzeler, Gregory S. Basarab, Richard T. Eastman, Jean Dam, Gurminder Kaur, André Horatscheck, Sonja B Lauterbach, Sabine Ottilie, Hui Guo, Michael J. Delves, Luisa Nardini, Jacek W. Zawada, Dennis A. Smith, James Duffy, Leslie J. Street, Tanya Paquet, Belinda C. Bezuidenhout, Claire Le Manach, Lyn-Marie Birkholtz, Dorjbal Dorjsuren, Liezl Gibhard, Dalu Mancama, Anton Simeonov, David A. Fidock, Christel Brunschwig, Sachel Mok, Daniel C. Talley, Nelius Venter, Mariëtte van der Watt, Grant A. Boyle, John G Woodland, Sergio Wittlin, Ayesha Aswat, Janette Reader, Nina Lawrence, Dale Taylor, Mathew Njoroge, Kelly Chibale, Tomas Yeo, Anjo Theron, Lutete Peguy Khonde, Erica Erlank, Thomas W. von Geldern, Kathryn J. Wicht
Publikováno v:
Journal of Medicinal Chemistry. 64:2291-2309
A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold p
Autor:
Anthony J. Smith, Dale Taylor, Anne J. Lenaerts, Thomas R. Ioerger, Nina Lawrence, Kelly Chibale, Rudolf Mueller, Vinayak Singh, Claire Le Manach, Aloysius T. Nchinda, Alissa Myrick, Mathew Njoroge, Paul M. Njaria, Elizabeth J. Brooks, Atica Moosa, Jessica N. Akester, Gregory T. Robertson
Publikováno v:
ACS Infectious Diseases
Phenotypic whole-cell screening against Mycobacterium tuberculosis (Mtb) in glycerol-alanine-salts supplemented with Tween 80 and iron (GASTE-Fe) media led to the identification of a 2-aminoquinazolinone hit compound, sulfone 1 which was optimized fo
Autor:
Maria G. Gomez-Lorenzo, Francisco-Javier Gamo, Claire Le Manach, Daniel E. Goldberg, Gavreel Kalantarov, Manu Vanaerschot, Anna Y. Burkhard, Jacquin C. Niles, Ioanna Deni, Olivia Coburn-Flynn, Jessica L. Bridgford, Tomoyo Sakata-Kato, Annie N. Cowell, Tomas Yeo, Rachel L. Edwards, Audrey R. Odom John, Sabine Ottilie, Charisse Flerida A. Pasaje, Ilya Trakht, Maëlle Duffey, Elizabeth A. Winzeler, Sachel Mok, Benoît Laleu, Sumanta Dey, Kelly Chibale, David A. Fidock, Kathryn J. Wicht, James M. Murithi, Amanda K. Lukens, Nina F. Gnädig, John Okombo, Dyann F. Wirth, Eva S. Istvan
Publikováno v:
Cell chemical biology. 29(5)
Summary Widespread Plasmodium falciparum resistance to first-line antimalarials underscores the vital need to develop compounds with novel modes of action and identify new druggable targets. Here, we profile five compounds that potently inhibit P. fa
Autor:
Claire, Le Manach, Jean, Dam, John G, Woodland, Gurminder, Kaur, Lutete P, Khonde, Christel, Brunschwig, Mathew, Njoroge, Kathryn J, Wicht, André, Horatscheck, Tanya, Paquet, Grant A, Boyle, Liezl, Gibhard, Dale, Taylor, Nina, Lawrence, Tomas, Yeo, Sachel, Mok, Richard T, Eastman, Dorjbal, Dorjsuren, Daniel C, Talley, Hui, Guo, Anton, Simeonov, Janette, Reader, Mariëtte, van der Watt, Erica, Erlank, Nelius, Venter, Jacek W, Zawada, Ayesha, Aswat, Luisa, Nardini, Theresa L, Coetzer, Sonja B, Lauterbach, Belinda C, Bezuidenhout, Anjo, Theron, Dalu, Mancama, Lizette L, Koekemoer, Lyn-Marie, Birkholtz, Sergio, Wittlin, Michael, Delves, Sabine, Ottilie, Elizabeth A, Winzeler, Thomas W, von Geldern, Dennis, Smith, David A, Fidock, Leslie J, Street, Gregory S, Basarab, James, Duffy, Kelly, Chibale
Publikováno v:
Journal of medicinal chemistry. 64(4)
A novel diazaspiro[3.4]octane series was identified from a
Autor:
Sabine Ottilie, Dale Taylor, Mariëtte van der Watt, Phanankosi Moyo, Lizette L. Koekemoer, Claire Le Manach, Daniel Opperman, James Duffy, Erica Erlank, Kelly Chibale, Sonja B Lauterbach, Lyn-Marie Birkholtz, Daniel E. Goldberg, Nimisha Mittal, Jessica I. Connacher, Lindsey M. Orchard, Ashleigh van Heerden, Natalie J. Spillman, Theresa L. Coetzer, Gregory S. Basarab, André Horatscheck, David Calvo, Elizabeth A. Winzeler, Anjo Theron, Janette Reader, Dalu Mancama, Nelius Venter, Grant A. Boyle, Eva S. Istvan, Manuel Llinás, Belinda C. Bezuidenhout, Luisa Nardini, Anne N. Cowell
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Chemical matter is needed to target the divergent biology associated with the different life cycle stages of Plasmodium. Here, we report the parallel de novo screening of the Medicines for Malaria Venture (MMV) Pandemic Response Box against Plasmodiu
Autor:
Jean Dam, Keletso Maepa, Lutete Peguy Khonde, Claire Le Manach, Janette Reader, Mariëtte van der Watt, Gregory S. Basarab, Sergio Wittlin, John Okombo, Kathryn J. Wicht, James Duffy, Aloysius T. Nchinda, Dale Taylor, André Horatscheck, Mathew Njoroge, Christel Brunschwig, Timothy J. Egan, Nina Lawrence, Ana Carolina C. de Sousa, Leslie J. Street, Kelly Chibale, Lyn-Marie Birkholtz, Ana Andrijevic, Liezl Gibhard, Tanya Paquet, Kailash P. Pawar, Paul V. Fish
Publikováno v:
J Med Chem
A series of 2,4-disubstituted imidazopyridines, originating from a SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0f65b29b16b46e7c416d1fc66f6377
https://europepmc.org/articles/PMC7756195/
https://europepmc.org/articles/PMC7756195/
Autor:
Sabine Ottilie, Belinda C. Bezuidenhout, Claire Le Manach, Sonja B Lauterbach, Grant A. Boyle, Dale Taylor, Mariёtte E. van der Watt, James Duffy, Janette Reader, Kelly Chibale, Gregory S. Basarab, Luisa Nardini, David Calvo, Erica Erlank, Theresa L. Coetzer, Dalu Mancama, Nimisha Mittal, Elizabeth A. Winzeler, Phanankosi Moyo, Nelius Venter, Lizette L. Koekemoer, Lyn-Marie Birkholtz, André Horatscheck, Anjo Theron, Ashleigh van Heerden
New chemical matter is needed to target the divergent biology associated with the different life cycle stages ofPlasmodium. Here, we report the parallel screening of the Medicines for Malaria Venture Pandemic Response Box to identify multistage-activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b62554483139943f425434f420265a7
https://doi.org/10.1101/2020.06.05.133405
https://doi.org/10.1101/2020.06.05.133405
Autor:
Claire Le Manach, Dale Taylor, Diego Gonzàlez Cabrera, James Duffy, Nina Lawrence, Santiago Ferrer, Kelly Chibale, Mathew Njoroge, Christel Brunschwig, Efrem Abay, Iñigo Angulo-Barturen, María-Belén Jiménez-Díaz, María Santos Martínez, Jeremy N. Burrows, Sergio Wittlin, Kathryn J. Wicht, Aloysius T. Nchinda, Tanya Paquet, Maria Jose Lafuente-Monasterio, Leslie J. Street
Publikováno v:
Journal of Medicinal Chemistry. 61:4213-4227
Optimization of a chemical series originating from whole-cell phenotypic screening against the human malaria parasite, Plasmodium falciparum, led to the identification of two promising 2,6-disubstituted imidazopyridine compounds, 43 and 74. These com
Autor:
Tanya Paquet, David A. Fidock, Efrem Abay, Iñigo Angulo-Barturen, Kigbafori D. Silué, Diego Gonzàlez Cabrera, Mathew Njoroge, Leslie J. Street, Rintis Noviyanti, Karen L. White, Grennady Wirjanata, Cristina Donini, Michael J Witty, Nina Lawrence, Dalu Mancama, Lyn-Marie Birkholtz, Claire Le Manach, Sergio Wittlin, Ric N. Price, María Belén Jiménez-Díaz, Lubbe Wiesner, Jutta Marfurt, Didier Leroy, David Waterson, Peter Siegl, Christel Brunschwig, Paul V. Fish, Aloysius T. Nchinda, Manu Vanaerschot, Jacob A. McPhail, Mariëtte van der Watt, Dale Taylor, Susan A. Charman, Gregory S. Basarab, Carmen de Kock, Esperanza Herreros, John E. Burke, Suresh Solapure, Kennan C. Marsh, Francisco-Javier Gamo, Kelly Chibale, Theresa L. Coetzer, James Duffy, Rosemary Rochford, Janette Reader, Paolo Denti, Dennis A. Smith, Benjamin Blasco
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62