Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Claire L. Newton"'
Autor:
Janine Suthiram, Ané Pieters, Zulfiah Mohamed Moosa, Jan Rijn Zeevaart, Mike M. Sathekge, Thomas Ebenhan, Ross C. Anderson, Claire L. Newton
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2134 (2023)
Radiopharmaceutical development hinges on the affinity and selectivity of the biological component for the intended target. An analogue of the neuropeptide Substance P (SP), 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-[Thi8,Met(O2)11]-SP
Externí odkaz:
https://doaj.org/article/c2f02b93f82d44cd93f835ef7a5bdecf
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8744 (2022)
Kisspeptin is an anti-metastatic mediator in many cancer types, acting through its receptor, KISS1R. However, controversy remains regarding its role in breast cancer since both pro- and anti-metastatic roles have been ascribed to it. In KISS1R overex
Externí odkaz:
https://doaj.org/article/8cab48cdca774d1fa939c9551c830fb2
Autor:
Ross C. Anderson, Sharika Hanyroup, Yong Bhum Song, Zulfiah Mohamed-Moosa, Iman van den Bout, Alexis C. Schwulst, Ursula B. Kaiser, Robert P. Millar, Claire L. Newton
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4587 (2022)
G protein-coupled receptors (GPCRs) facilitate the majority of signal transductions across cell membranes in humans, with numerous diseases attributed to inactivating GPCR mutations. Many of these mutations result in misfolding during nascent recepto
Externí odkaz:
https://doaj.org/article/2655fb8f27db4e538e111a1357589882
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2019)
The follicle-stimulating hormone receptor (FSHR) has been targeted therapeutically for decades, due to its pivotal role in reproduction. To date, only purified and recombinant/biosimilar FSH have been used to target FSHR in assisted reproduction, wit
Externí odkaz:
https://doaj.org/article/5b008010569545ac9e2700878afbd892
Autor:
Samantha Sperduti, Silvia Limoncella, Clara Lazzaretti, Elia Paradiso, Laura Riccetti, Sara Turchi, Ilaria Ferrigno, Jessika Bertacchini, Carla Palumbo, Francesco Potì, Salvatore Longobardi, Robert P. Millar, Manuela Simoni, Claire L. Newton, Livio Casarini
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 22, p 5548 (2019)
Commercial gonadotropin-releasing hormone (GnRH) antagonists differ by 1−2 amino acids and are used to inhibit gonadotropin production during assisted reproduction technologies (ART). In this study, potencies of three GnRH antagonists, Cetrorelix,
Externí odkaz:
https://doaj.org/article/76e6bbc3853545dc89f49aead81c58b5
Analogues of hypothalamic/pituitary/gonadal hormone regulators for the management pubertal disorders
Autor:
Claire L. Newton, Robert P. Millar
Publikováno v:
Current Opinion in Endocrine and Metabolic Research. 14:169-178
Gonadotropin-releasing hormone (GnRH) synthesised in the hypothalamus stimulates the secretion of gonadotropins which in turn stimulate gametogenesis and sex hormone production. This hypothalamic–pituitary–gonadal (HPG) axis is central to the tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dab8c6050e35d20669c452343c767f88
https://doi.org/10.1016/j.coemr.2020.09.007
https://doi.org/10.1016/j.coemr.2020.09.007
Autor:
Selvaraj Nataraja, Henry N Yu, Claire L. Newton, Sharika Hanyroup, Ross Anderson, Robert P. Millar
Publikováno v:
Endocrinology. 162(12)
Mutations in G protein-coupled receptors (GPCRs) underlie numerous diseases. Many cause receptor misfolding and failure to reach the cell surface. Pharmacological chaperones are cell-permeant small molecules that engage nascent mutant GPCRs in the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca79482a5dd3fd85909ac000d5baece
https://pubmed.ncbi.nlm.nih.gov/34192304
https://pubmed.ncbi.nlm.nih.gov/34192304
Autor:
Claire L. Newton, Robert P. Millar, Ross Anderson, Annika Kreuchwig, Arieh A. Katz, Gerd Krause
Publikováno v:
Neuroendocrinology. 111(5)
Introduction: G protein-coupled receptor (GPCR) mutations are implicated in many diseases. Most inactivating mutations cause receptor misfolding and prevent trafficking to the plasma membrane. Pharmacological chaperones can “rescue” cell surface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e74edbb388a1b92a12abad6a7a5ace
https://pubmed.ncbi.nlm.nih.gov/32316022
https://pubmed.ncbi.nlm.nih.gov/32316022
Publikováno v:
Anderson, R C, Newton, C L, Anderson, R & Millar, R 2018, ' Gonadotropins and their analogues: current and potential clinical applications ', Endocrine Reviews . https://doi.org/10.1210/er.2018-00052
The gonadotropin receptors LH receptor and FSH receptor play a central role in governing reproductive competency/fertility. Gonadotropin hormone analogs have been used clinically for decades in assisted reproductive therapies and in the treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5c1043cb0f27d60eaffa7f1a5685e8
https://doi.org/10.1210/er.2018-00052
https://doi.org/10.1210/er.2018-00052
Autor:
Livio Casarini, Claire L. Newton, Manuela Simoni, Clara Lazzaretti, Robert P. Millar, Ilaria Ferrigno, Samantha Sperduti, Francesco Potì, Carla Palumbo, Salvatore Longobardi, Laura Riccetti, Elia Paradiso, Jessika Bertacchini, Sara Turchi, Silvia Limoncella
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2019, 20 (22), pp.5548. ⟨10.3390/ijms20225548⟩
International Journal of Molecular Sciences, Vol 20, Iss 22, p 5548 (2019)
International Journal of Molecular Sciences 22 (20), . (2019)
Volume 20
Issue 22
International Journal of Molecular Sciences, MDPI, 2019, 20 (22), pp.5548. ⟨10.3390/ijms20225548⟩
International Journal of Molecular Sciences, Vol 20, Iss 22, p 5548 (2019)
International Journal of Molecular Sciences 22 (20), . (2019)
Volume 20
Issue 22
Commercial gonadotropin-releasing hormone (GnRH) antagonists differ by 1&ndash
2 amino acids and are used to inhibit gonadotropin production during assisted reproduction technologies (ART). In this study, potencies of three GnRH antagonists, Cet
2 amino acids and are used to inhibit gonadotropin production during assisted reproduction technologies (ART). In this study, potencies of three GnRH antagonists, Cet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe8bf1a95a2813ce5c40fcc64fec10d
https://hal.archives-ouvertes.fr/hal-02501225
https://hal.archives-ouvertes.fr/hal-02501225
