Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Claire L. Donohoe"'
Autor:
Louise Brennan, Grainne Sheill, Sonya Collier, Peter Browne, Claire L. Donohoe, Linda O’Neill, Juliette Hussey, Emer M. Guinan
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background To effectively embed exercise rehabilitation in cancer survivorship care, a co-ordinated system of acute and community exercise rehabilitation services, forming a stepped model of care, is recommended. Patients can be directed to
Externí odkaz:
https://doaj.org/article/d045942cdfb744a7b465a8f0b74765ce
Autor:
Maria Davern, Cillian O’ Donovan, Noel E. Donlon, Eimear Mylod, Caoimhe Gaughan, Anshul Bhardwaj, Andrew D. Sheppard, Dara Bracken-Clarke, Christine Butler, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght, Melissa J. Conroy
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 819 (2024)
The presence of an immunosuppressive tumour microenvironment in oesophageal adenocarcinoma (OAC) is a major contributor to poor responses. Novel treatment strategies are required to supplement current regimens and improve patient survival. This study
Externí odkaz:
https://doaj.org/article/3ca4eb6b6a0845a7a2adb872372af596
Autor:
Maria Davern, Caoimhe Gaughan, Fiona O’ Connell, Brendan Moran, Eimear Mylod, Andrew D. Sheppard, Sinead Ramjit, Jasmine Yun-Tong Kung, James J. Phelan, Matthew G. Davey, Eanna J. Ryan, Christine Butler, Laura Quinn, Claudine Howard, Emily Tone, Eimear Phoenix, Waqas T. Butt, Niamh Lynam-Lennon, Stephen G. Maher, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght, Noel E. Donlon
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThis timely study assesses the immunosuppressive effects of surgery on cytotoxic Th1-like immunity and investigates if immune checkpoint blockade (ICB) can boost Th1-like immunity in the perioperative window in upper gastrointestinal canc
Externí odkaz:
https://doaj.org/article/e9a76b77fe4448bca0dc1485f4477ae2
Autor:
Sarah Bennett, Conor F. Murphy, Michelle Fanning, John V. Reynolds, Suzanne L. Doyle, Claire L. Donohoe
Publikováno v:
Clinical Nutrition Open Science, Vol 41, Iss , Pp 44-61 (2022)
Summary: Background and Aims: Oesophagectomy is the primary curative treatment for oesophageal cancer but is associated with considerable postoperative morbidity and mortality. To better understand the aetiology of impaired health-related quality of
Externí odkaz:
https://doaj.org/article/01e855515d38491cbd0fc9a660399d68
Autor:
Fiona O’Connell, Eimear Mylod, Noel E. Donlon, Aisling B. Heeran, Christine Butler, Anshul Bhardwaj, Sinead Ramjit, Michael Durand, Gerard Lambe, Paul Tansey, Ivan Welartne, Kevin P. Sheahan, Xiaofei Yin, Claire L. Donohoe, Narayanasamy Ravi, Margaret R. Dunne, Lorraine Brennan, John V. Reynolds, Helen M. Roche, Jacintha O’Sullivan
Publikováno v:
Cancers, Vol 15, Iss 6, p 1681 (2023)
Oesophageal adenocarcinoma (OAC) is a poor prognosis cancer with limited response rates to current treatment modalities and has a strong link to obesity. To better elucidate the role of visceral adiposity in this disease state, a full metabolic profi
Externí odkaz:
https://doaj.org/article/60f45e8ebed54b9eabadadf6e1e47dc7
Autor:
Noel E. Donlon, Maria Davern, Andrew D. Sheppard, Fiona O’Connell, Margaret R. Dunne, Conall Hayes, Eimear Mylod, Sinead Ramjit, Hugo Temperley, Michael Mac Lean, Gillian Cotter, Anshul Bhardwaj, Christine Butler, Melissa J. Conroy, Jacintha O’Sullivan, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundImmune checkpoint inhibitors (ICIs) are being investigated for their role as an adjunct in the multimodal treatment of esophageal adenocarcinoma (EAC). The most effective time to incorporate ICIs remains unknown. Our study profiles systemic
Externí odkaz:
https://doaj.org/article/c1c43e80139b48f2bdb847aa34f8da63
Autor:
Noel E. Donlon, Maria Davern, Andrew Sheppard, Robert Power, Fiona O’Connell, Aisling B. Heeran, Ross King, Conall Hayes, Anshul Bhardwaj, James J. Phelan, Margaret R. Dunne, Narayanasamy Ravi, Claire L. Donohoe, Jacintha O’Sullivan, John V. Reynolds, Joanne Lysaght
Publikováno v:
Cancers, Vol 13, Iss 16, p 4005 (2021)
Response rates to the current gold standards of care for treating oesophageal adenocarcinoma (OAC) remain modest with 15–25% of patients achieving meaningful pathological responses, highlighting the need for novel therapeutic strategies. This study
Externí odkaz:
https://doaj.org/article/f9614f8892c540978cec164f122a4666
Autor:
Noel E. Donlon, Andrew Sheppard, Maria Davern, Fiona O’Connell, James J. Phelan, Robert Power, Timothy Nugent, Kate Dinneen, John Aird, John Greene, Paul Nevins Selvadurai, Anshul Bhardwaj, Emma K. Foley, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght, Jacintha O’Sullivan, Margaret R. Dunne
Publikováno v:
Cancers, Vol 12, Iss 11, p 3356 (2020)
Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor prognosis and incidence is increasing rapidly in the Western world. Multi-modal treatment has improved survival outcomes but only for a minority of patients. Currently no markers have
Externí odkaz:
https://doaj.org/article/b32420d768d24c7bb6414bf797b1d002
Autor:
Anantha Madhavan, Alexander W. Phillips, Claire L. Donohoe, Rebecca J. Willows, Arul Immanuel, Mark Verril, S. Michael Griffin
Publikováno v:
Gastroenterology Research and Practice, Vol 2018 (2018)
Gastrointestinal stromal tumours (GISTs) most commonly originate from the stomach. Their treatment is dependent on size and whether they are symptomatic. Curative treatment requires surgery, which may be preceded by neoadjuvant imatinib if it is felt
Externí odkaz:
https://doaj.org/article/faadddd8dec945739f542b1e0167adf5
Publikováno v:
Gastroenterology Research and Practice, Vol 2011 (2011)
Cachexia is a multifactorial process of skeletal muscle and adipose tissue atrophy resulting in progressive weight loss. It is associated with poor quality of life, poor physical function, and poor prognosis in cancer patients. It involves multiple p
Externí odkaz:
https://doaj.org/article/f4e32a5b4de44529bf693ec96af9f7bc