Zobrazeno 1 - 10 of 46 pro vyhledávání: '"Claire L Lyons"'
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Akademický článek
Apolipoprotein A-I priming via SR-BI and ABCA1 receptor binding upregulates mitochondrial metabolism to promote insulin secretion in INS-1E cells.
Autor: Claire L Lyons, Elaine Cowan, Oktawia Nilsson, Manca Mohar, Pablo Peña-Martínez, Lena Eliasson, Jens O Lagerstedt
Publikováno v: PLoS ONE, Vol 19, Iss 11, p e0311039 (2024)
Apolipoprotein A-I (ApoA-I), the primary component of high-density lipoprotein (HDL) cholesterol primes β-cells to increase insulin secretion, however, the mechanisms involved are not fully defined. Here, we aimed to confirm ApoA-I receptors in β-c
Externí odkaz: https://doaj.org/article/afa99b8bdf8b4321a1e44d44ed27a9f7
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2
Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets
Autor: Karl Bacos, Alexander Perfilyev, Alexandros Karagiannopoulos, Elaine Cowan, Jones K. Ofori, Ludivine Bertonnier-Brouty, Tina Rönn, Andreas Lindqvist, Cheng Luan, Sabrina Ruhrmann, Mtakai Ngara, Åsa Nilsson, Sevda Gheibi, Claire L. Lyons, Jens O. Lagerstedt, Mohammad Barghouth, Jonathan L.S. Esguerra, Petr Volkov, Malin Fex, Hindrik Mulder, Nils Wierup, Ulrika Krus, Isabella Artner, Lena Eliasson, Rashmi B. Prasad, Luis Rodrigo Cataldo, Charlotte Ling
Publikováno v: Bacos, K, Perfilyev, A, Karagiannopoulos, A, Cowan, E, Ofori, J K, Bertonnier-Brouty, L, Rönn, T, Lindqvist, A, Luan, C, Ruhrmann, S, Ngara, M, Nilsson, Å, Gheibi, S, Lyons, C L, Lagerstedt, J O, Barghouth, M, Esguerra, J L S, Volkov, P, Fex, M, Mulder, H, Wierup, N, Krus, U, Artner, I, Eliasson, L, Prasad, R B, Cataldo, L R & Ling, C 2023, ' Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets ', Journal of Clinical Investigation, vol. 133, no. 4, e163612 . https://doi.org/10.1172/JCI163612
Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β cells. To identify candidate genes contributing to T2D pathophysiology, we studied human pancreatic islets from approximately 300 individuals. We found 395 different
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323fcd652f45614ce94f0d41ef48e25d
https://doi.org/10.1172/jci163612
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3
Dietary substitution of SFA with MUFA within high-fat diets attenuates hyperinsulinaemia and pancreatic islet dysfunction
Autor: Helen M. Roche, Jessica C. Ralston, Marie-Sophie Nguyen-Tu, Orla M. Finucane, Fiona C. McGillicuddy, Aoife M. Murphy, Guy A. Rutter, Claire L. Lyons, Aidan Falvey, Aoife A. Cooke
Publikováno v: British Journal of Nutrition. 124:247-255
Preliminary evidence has suggested that high-fat diets (HFD) enriched with SFA, but not MUFA, promote hyperinsulinaemia and pancreatic hypertrophy with insulin resistance. The objective of this study was to determine whether the substitution of dieta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f33825625abacc6b44ae8ae3b9d886
https://doi.org/10.1017/s0007114520000859
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DIMT1, a regulator of ribosomal biogenesis, controls β-cell protein synthesis, mitochondrial function and insulin secretion
Autor: Alexander Bowen, Rodrigo Cataldo Buscunan, Alexander Hamilton, Claire L. Lyons, Gaurav Verma, Hindrik Mulder, Malin Fex, Jonathan L.S. Esguerra, Alexandros Karagiannopoulos, Elaine Cowan
We previously reported that transcription factor B1 mitochondrial (TFB1M) is involved in the pathogenesis of type 2 diabetes (T2D) owing to mitochondrial dysfunction. Here, we describe that dimethyladenosine transferase 1 homolog (DIMT1), a homologue
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4781b4a9935b4871648f494d21d8f345
https://doi.org/10.1101/2020.09.27.313262
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6
Fatty acids and chronic low grade inflammation associated with obesity and the metabolic syndrome
Autor: Aoife A. Cooke, Helen M. Roche, Claire L. Lyons, Ruth M. Connaughton, Aoibheann M McMorrow
Publikováno v: European Journal of Pharmacology. 785:207-214
The metabolic syndrome is a group of obesity associated metabolic conditions that result in increased risk of cardiovascular disease and type 2 diabetes. Global increases in obesity rates have led to an increase in metabolic syndrome resulting in a d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0d49875914fd7f6e1c3f5234c51e33
https://doi.org/10.1016/j.ejphar.2016.04.021
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High-Density Lipoprotein Proteomic Composition, and not Efflux Capacity, Reflects Differential Modulation of Reverse Cholesterol Transport by Saturated and Monounsaturated Fat Diets
Autor: Aoibheann M McMorrow, Lorraine Brennan, M. O'Reilly, Eileen R. Gibney, Michael J. Gibney, Helen M. Roche, Margarita de la Llera Moya, Daniel Jones, Orla M. Finucane, Miriam F. Ryan, Muredach P. Reilly, Aoife M. Murphy, Claire L. Lyons, Fiona C. McGillicuddy, Weili Guo, Eugene T. Dillon
Publikováno v: O'Reilly, M, Dillon, E, Guo, W, Finucane, O, McMorrow, A, Murphy, A, Lyons, C, Jones, D, Ryan, M, Gibney, M, Gibney, E, Brennan, L, De La Llera Moya, M, Reilly, M P, Roche, H M & McGillicuddy, F C 2016, ' High-density lipoprotein proteomic composition, and not efflux capacity, reflects differential modulation of reverse cholesterol transport by saturated and monounsaturated fat diets ' Circulation, vol. 133, no. 19, pp. 1838-1850 . DOI: 10.1161/CIRCULATIONAHA.115.020278
Background— Acute inflammation impairs reverse cholesterol transport (RCT) and reduces high-density lipoprotein (HDL) function in vivo. This study hypothesized that obesity-induced inflammation impedes RCT and alters HDL composition, and investigat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735bd74f1db2fdd73a4039ab1ca64763
https://doi.org/10.1161/circulationaha.115.020278
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9
Interactions between differential fatty acids and inflammatory stressors—impact on metabolic health
Autor: Orla M. Finucane, Helen M. Roche, Aoife M. Murphy, Claire L. Lyons
Publikováno v: Prostaglandins, Leukotrienes and Essential Fatty Acids. 92:49-55
Current interest in obesity has established a clear link between diets high in fat and metabolic complications such as Type 2 Diabetes. Dietary fats and their metabolites act as stressors to induce a pro-inflammatory immune response which dysregulate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e36015154d3334e5d73729c9784da9
https://doi.org/10.1016/j.plefa.2014.05.003
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10
Fatty Acids and NLRP3 Inflammasome-Mediated Inflammation in Metabolic Tissues
Autor: Elaine B. Kennedy, Claire L. Lyons, Jessica C. Ralston, Helen M. Roche, Anna M. Kirwan
Publikováno v: Annual review of nutrition. 37
Worldwide obesity rates have reached epidemic proportions and significantly contribute to the growing prevalence of metabolic diseases. Chronic low-grade inflammation, a hallmark of obesity, involves immune cell infiltration into expanding adipose ti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93982c45e79c97c78a2e9535efdce455
https://pubmed.ncbi.nlm.nih.gov/28826373
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