Impulsive choices in mice lacking imprinted Nesp55

Autor: Antonius Plagge, Katie Lewis, Trevor Humby, Claire L. Dent, Anthony Roger Isles, Reiner Fischer-Colbrie, Jon F. Wilkins, Lawrence Stephen Wilkinson

Publikováno v: Genes, Brain and Behavior. 15:693-701

Genomic imprinting is the process whereby germline epigenetic events lead to parent-of-origin specific monallelic expression of a number of key mammalian genes. The imprinted gene Nesp is expressed from the maternal allele only and encodes for Nesp55

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5b9301cf00a9aee3c01ef9aa4d5f934
https://doi.org/10.1111/gbb.12316

Behavioural effects of imprinted genes

Autor: Claire L. Dent, Grainne McNamara, Jennifer R. Davies, Anthony Roger Isles

Publikováno v: Current Opinion in Behavioral Sciences. 2:28-33

The importance of imprinted gene effects on brain and behaviour is becoming increasingly clear. In addition to roles in neurodevelopmental disorders such as Prader–Willi and Angelman syndromes, changes in expression of imprinted genes contribute to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa54079424aa8a084363cfc68b39c57a
https://doi.org/10.1016/j.cobeha.2014.07.008

An Overview of Measuring Impulsive Behavior in Mice

Autor: Anthony Roger Isles, Claire L. Dent

Publikováno v: Current Protocols in Mouse Biology

Impulsive behavior is a key constituent of many psychiatric illnesses, with maladaptive response control being a feature of disorders such as ADHD, schizophrenia, mania, and addiction. In order to understand the neurological underpinnings of impulsiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3da3c12bc681d1b7df0988d49dc97e28
https://doi.org/10.1002/9780470942390.mo140015

Fetus-derived DLK1 is required for maternal metabolic adaptations to pregnancy and is associated with fetal growth restriction

Autor: Anne C. Ferguson-Smith, Marika Charalambous, Nozomi Takahashi, Steven R. Bauer, Ulla Sovio, Claire L Dent, Mary Ann Megan Cleaton, D Steven Charnock-Jones, Isabelle Gutteridge, Gordon C. S. Smith, Jennifer A. Corish, Francesca Gaccioli, Mark Howard, Theresa L. Powell

Publikováno v: Cleaton, M A M, Dent, C L, Howard, M, Corish, J A, Gutteridge, I, Sovio, U, Gaccioli, F, Takahashi, N, Bauer, S R, Charnock-Jones, D S, Powell, T L, Smith, G C S, Ferguson-Smith, A C & Charalambous, M 2016, ' Fetus-derived DLK1 is required for maternal metabolic adaptations to pregnancy and is associated with fetal growth restriction ', Nature Genetics, vol. 48, no. 12, pp. 1473-1480 . https://doi.org/10.1038/ng.3699

M.A.M.C. was supported by a PhD studentship from the Cambridge Centre for Trophoblast Research. Research was supported by grants from the MRC (MR/J001597/1 and MR/L002345/1), the Medical College of Saint Bartholomew's Hospital Trust, a Wellcome Trust

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37eb05d435ddf20667cef4d42c4abed
https://pubmed.ncbi.nlm.nih.gov/27811939

Placental programming of anxiety in adulthood revealed by Igf2-null models

Autor: Miguel Constância, Lawrence Stephen Wilkinson, Mikael Allan Mikaelsson, Claire L. Dent, Trevor Humby

Publikováno v: Nature Communications. 4

Imprinted, maternally silenced insulin-like growth factor-2 is expressed in both the foetus and placenta and has been shown to have roles in foetal and placental development in animal models. Here we compared mice engineered to be null for the placen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c98d1fcc8ffed3bc1d1c82653336c1
https://doi.org/10.1038/ncomms3311