Mass spectrometry imaging discriminates glioblastoma tumor cell subpopulations and different microvascular formations based on their lipid profiles

Autor: Kelly C. O’Neill, Evangelos Liapis, Brent T. Harris, David S. Perlin, Claire L. Carter

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)

Abstract Glioblastoma is a prevalent malignant brain tumor and despite clinical intervention, tumor recurrence is frequent and usually fatal. Genomic investigations have provided a greater understanding of molecular heterogeneity in glioblastoma, yet

Externí odkaz: https://doaj.org/article/9c22de6e32cd4b5792d6d99ccc70f3f5

The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science

Autor: Jena V. Lilly, Jo Lynne Rokita, Jennifer L. Mason, Tatiana Patton, Stephanie Stefankiewiz, David Higgins, Gerri Trooskin, Carina A. Larouci, Kamnaa Arya, Elizabeth Appert, Allison P. Heath, Yuankun Zhu, Miguel A. Brown, Bo Zhang, Bailey K. Farrow, Shannon Robins, Allison M. Morgan, Thinh Q. Nguyen, Elizabeth Frenkel, Kaitlin Lehmann, Emily Drake, Catherine Sullivan, Alexa Plisiewicz, Noel Coleman, Luke Patterson, Mateusz Koptyra, Zeinab Helili, Nicholas Van Kuren, Nathan Young, Meen Chul Kim, Christopher Friedman, Alex Lubneuski, Christopher Blackden, Marti Williams, Valerie Baubet, Lamiya Tauhid, Jamie Galanaugh, Katie Boucher, Heba Ijaz, Kristina A. Cole, Namrata Choudhari, Mariarita Santi, Robert W. Moulder, Jonathan Waller, Whitney Rife, Sharon J. Diskin, Marion Mateos, Donald W. Parsons, Ian F. Pollack, Stewart Goldman, Sarah Leary, Chiara Caporalini, Anna Maria Buccoliero, Mirko Scagnet, David Haussler, Derek Hanson, Ron Firestein, Jason Cain, Joanna J. Phillips, Nalin Gupta, Sabine Mueller, Gerald Grant, Michelle Monje-Deisseroth, Sonia Partap, Jeffrey P. Greenfield, Rintaro Hashizume, Amy Smith, Shida Zhu, James M. Johnston, Jason R. Fangusaro, Matthew Miller, Matthew D. Wood, Sharon Gardner, Claire L. Carter, Laura M. Prolo, Jared Pisapia, Katherine Pehlivan, Andrea Franson, Toba Niazi, Josh Rubin, Mohamed Abdelbaki, David S. Ziegler, Holly B. Lindsay, Ana Guerreiro Stucklin, Nicolas Gerber, Olena M. Vaske, Carolyn Quinsey, Brian R. Rood, Javad Nazarian, Eric Raabe, Eric M. Jackson, Stacie Stapleton, Robert M. Lober, David E. Kram, Carl Koschmann, Phillip B. Storm, Rishi R. Lulla, Michael Prados, Adam C. Resnick, Angela J. Waanders

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 35, Iss , Pp 100846- (2023)

Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term

Externí odkaz: https://doaj.org/article/ccba034296a747dd98510c07ca0814c3

On-Slide Heat Sterilization Enables Mass Spectrometry Imaging of Tissue Infected with High-Threat Pathogens Outside of Biocontainment: A Study Directed at Mycobacterium tuberculosis

Autor: Claire L Carter, Han Wang, Matthew C. Zimmerman, Jansy Sarathy, Véronique Dartois, Ning Wang, Firat Kaya

Publikováno v: Journal of the American Society for Mass Spectrometry. 32:2664-2674

Mass spectrometry imaging investigations of tissues infected with agents that require high-security biocontainment, such as Mycobacterium tuberculosis, have been limited due to incompatible sterilization techniques. Here we describe an on-slide heat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf090c1db784fbbb51e467774a9e20b2
https://doi.org/10.1021/jasms.1c00205

Spatial quantitation of antibiotics in bone tissue compartments by laser-capture microdissection coupled with UHPLC-tandem mass spectrometry

Autor: Firat Kaya, Matthew D. Zimmerman, Rosleine Antilus-Sainte, Martin Gengenbacher, Claire L. Carter, Véronique Dartois

Publikováno v: Analytical and bioanalytical chemistry. 414(23)

Bones are the site of multiple diseases requiring chemotherapy, including cancer, arthritis, osteoporosis and infections. Yet limited methodologies are available to investigate the spatial distribution and quantitation of small molecule drugs in bone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d881aa4f29ee5d37c290843739048c
https://pubmed.ncbi.nlm.nih.gov/35945288

Drug concentration at the site of disease in children with pulmonary tuberculosis

Autor: Elisa Lopez-Varela, Ahmed A. Abulfathi, Natasha Strydom, Pierre Goussard, Abraham C. van Wyk, Anne Marie Demers, Anneen Van Deventer, Anthony J. Garcia-Prats, Johannes van der Merwe, Matthew Zimmerman, Claire L. Carter, Jacques Janson, Julie Morrison, Helmuth Reuter, Eric H. Decloedt, James A. Seddon, Elin M. Svensson, Rob Warren, Radojka M. Savic, Véronique Dartois, Anneke C. Hesseling

Publikováno v: The Journal of antimicrobial chemotherapy, vol 77, iss 6
Journal of Antimicrobial Chemotherapy, 77, 1710-1719
Journal of Antimicrobial Chemotherapy, 77, 6, pp. 1710-1719

Background Current TB treatment for children is not optimized to provide adequate drug levels in TB lesions. Dose optimization of first-line antituberculosis drugs to increase exposure at the site of disease could facilitate more optimal treatment an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37195cfa7b06d03c84cf1884d892c4c7
https://pubmed.ncbi.nlm.nih.gov/35468189