SLPI deficiency alters airway protease activity and induces cell recruitment in a model of muco-obstructive lung disease

Autor: Ryan Brown, Caoifa Dougan, Peter Ferris, Rebecca Delaney, Claire J. Houston, Aoife Rodgers, Damian G. Downey, Marcus A. Mall, Bronwen Connolly, Donna Small, Sinéad Weldon, Clifford C. Taggart

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Secretory leukocyte protease inhibitor (SLPI) is an important cationic protein involved in innate airway immunity and highly expressed in mucosal secretions, shown to target and inhibit neutrophil elastase (NE), cathepsin G and trypsin activity to li

Externí odkaz: https://doaj.org/article/438d37d1f0ab439ab6b29c4beb7f6c88

Airway Inflammation and Host Responses in the Era of CFTR Modulators

Autor: Daniel F. McAuley, Joseph C. Kidney, Claire J Houston, Michael C. McKelvey, Dermot Linden, Damian G Downey, Shannice Creane, Declan Doherty, Clifford C. Taggart, Karen Keown, Ryan Brown, Sinéad Weldon

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 6379, p 6379 (2020)
International Journal of Molecular Sciences
Keown, K, Brown, R, Doherty, D F, Houston, C, McKelvey, M C, Creane, S, Linden, D, McAuley, D F, Kidney, J C, Weldon, S, Downey, D G & Taggart, C C 2020, ' Airway Inflammation and Host Responses in the Era of CFTR Modulators ', International journal of molecular sciences, vol. 21, no. 17 . https://doi.org/10.3390/ijms21176379

The arrival of cystic fibrosis transmembrane conductance regulator (CFTR) modulators as a new class of treatment for cystic fibrosis (CF) in 2012 represented a pivotal advance in disease management, as these small molecules directly target the upstre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917c6f796b9931b8715cfb8d433cecda
https://www.mdpi.com/1422-0067/21/17/6379