Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Claire J. Garwood"'
Autor:
Scott P. Allen, Rajpinder Singh Seehra, Paul R. Heath, Benjamin P. C. Hall, Jessica Bates, Claire J. Garwood, Martyna M. Matuszyk, Stephen B. Wharton, Julie E. Simpson
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 8028 (2020)
Hypoxia is a feature of neurodegenerative diseases, and can both directly and indirectly impact on neuronal function through modulation of glial function. Astrocytes play a key role in regulating homeostasis within the central nervous system, and med
Externí odkaz:
https://doaj.org/article/58ac9fb6b2bb4dc3bb18f7fcdc0fb23d
Autor:
Motaz M. Fadul, Claire J. Garwood, Rachel Waller, Navonna Garrett, Paul R. Heath, Fiona E Matthews, Carol Brayne, Stephen B. Wharton, Julie E. Simpson
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 1, p 340 (2020)
Astrocytes play a major role in the pathogenesis of a range of neurodegenerative diseases, including Alzheimer’s disease (AD), undergoing dramatic morphological and molecular changes that can cause potentially both beneficial and detrimental effect
Externí odkaz:
https://doaj.org/article/27ce3562c42740778788cd6919433473
Autor:
Claire J. Garwood, Stephen B. Wharton, Julie E. Simpson, Martyna M. Matuszyk, Rosemary A. Staniforth, Laura Ferraiuolo
Publikováno v:
Journal of Neurochemistry. 160:434-453
Although controversial, the amyloid cascade hypothesis remains central to the Alzheimer’s disease (AD) field and posits amyloid- beta (Aβ) as the central factor initiating disease onset. In recent years, there has been an increase in emphasis on s
Autor:
Claire J. Garwood, Irina Vazquez-Villasenor, Paul R. Heath, Julie E. Simpson, Stephen B. Wharton, Heather Mortiboys
Publikováno v:
European Journal of Neuroscience. 54:6987-7005
Oxidative DNA damage induces changes in the neuronal cell cycle and activates a DNA damage response (DDR) to promote repair, but these processes may be altered under a chronic oxidative environment, leading to the accumulation of unrepaired DNA damag
Autor:
Jennifer C. Louth, Imane Ghafir El Idrissi, James D Grayson, Valerie J. Gillet, Sasha Stimpson, Emma Mead, Antonio de la Vega de León, Margarita Segovia Roldan, Gary Sharman, Claire J. Garwood, Jim A. Thomas, Matthew P. Baumgartner, Amélia P. Rauter, Beining Chen, Samuel J Dawes, Joanna Wolak, Charlotte Dunbar, Ke Ning, Anastasia Zhuravleva, Cleide dos Santos Souza, Benjamin M. Partridge, Nicola Antonio Colabufo, David A. Evans
Publikováno v:
Chemical Science. 12:3768-3785
Amyloid β oligomers (Aβo) are the main toxic species in Alzheimer's disease, which have been targeted for single drug treatment with very little success. In this work we report a new approach for identifying functional Aβo binding compounds. A tai
Autor:
Luke Jennings, Irina Vázquez Villaseñor, Evangelia Karyka, Paul R. Heath, Heather Mortiboys, Aurelie Schwartzentruber, Paul G. Ince, Julie E. Simpson, Claire J. Garwood, Laura E. Ratcliffe, Stephen B. Wharton
Publikováno v:
Neuroscience
Highlights • We have established a novel human astrocyte-neuron co-culture system. • Astrocytes provided contact-mediated support for neurite outgrowth. • IGF1R-impaired astrocytes are less able to protect neurons under stress conditions. • M
Autor:
Claire J. Garwood, M Teresa Blázquez-Sánchez, Andreia Bento-Oliveira, Filipa Marcelo, Amélia P. Rauter, Joana S. Cristóvão, Pedro Lopes, José G. Fernández-Bolaños, Nicola Antonio Colabufo, Ke Ning, Ana Diniz, Cláudio M. Gomes, Ana M. Matos, Rafael Nunes, M Conceição Oliveira, Imane Ghafir El Idrissi, Beat Ernst, Cleide dos Santos Souza, Beining Chen, Rodrigo F.M. de Almeida, Philipp Dätwyler, Miguel Machuqueiro, Óscar López
Publikováno v:
Journal of medicinal chemistry. 63(20)
Despite the rapidly increasing number of patients suffering from type 2 diabetes, Alzheimer's disease, and diabetes-induced dementia, there are no disease-modifying therapies that are able to prevent or block disease progress. In this work, we invest
Autor:
Stephen B. Wharton, Paul G. Ince, Thais Minett, Paul R. Heath, Pamela J. Shaw, Joanna J. Bury, C Richardson, Julie E. Simpson, Fiona E. Matthews, Claire J. Garwood, Carol Brayne, Annabelle Chambers
Diabetes mellitus is a risk factor for dementia, and nonenzymatic glycosylation of macromolecules results in formation of advanced glycation end-products (AGEs). We determined the variation in AGE formation in brains from the Cognitive Function and A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ade62b0f9686d050b49b76991b3609
https://www.repository.cam.ac.uk/handle/1810/311976
https://www.repository.cam.ac.uk/handle/1810/311976
Autor:
Claire J. Garwood, Julie E. Simpson, Fiona E. Matthews, Navonna Garrett, Stephen B. Wharton, Rachel Waller, Carol Brayne, Paul R. Heath, Motaz M. Fadul
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 1, p 340 (2020)
International Journal of Molecular Sciences, Vol 21, Iss 1, p 340 (2020)
Astrocytes play a major role in the pathogenesis of a range of neurodegenerative diseases, including Alzheimer’s disease (AD), undergoing dramatic morphological and molecular changes that can cause potentially both beneficial and detrimental effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c6658f10ada973aa8864bbc2f7bd43
https://www.repository.cam.ac.uk/handle/1810/302376
https://www.repository.cam.ac.uk/handle/1810/302376