Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Claire J Cairney"'
Autor:
Claire J Cairney, Lauren S Godwin, Alan E Bilsland, Sharon Burns, Katrina H Stevenson, Lynn McGarry, John Revie, Jon D Moore, Ceri M Wiggins, Rebecca S Collinson, Clare Mudd, Elpida Tsonou, Mahito Sadaie, Dorothy C Bennett, Masashi Narita, Christopher J Torrance, W Nicol Keith
Publikováno v:
PLoS Genetics, Vol 13, Iss 8, p e1006942 (2017)
Senescence is a universal barrier to immortalisation and tumorigenesis. As such, interest in the use of senescence-induction in a therapeutic context has been gaining momentum in the past few years; however, senescence and immortalisation remain unde
Externí odkaz:
https://doaj.org/article/9c37fdc4728e4b2584673b3d2d9b5b8b
Autor:
Juan Manuel Iglesias, Claire J Cairney, Roderick K Ferrier, Laura McDonald, Kelly Soady, Howard Kendrick, Marie-Anne Pringle, Reginald O Morgan, Finian Martin, Matthew J Smalley, Karen Blyth, Torsten Stein
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119718 (2015)
We have previously shown that Annexin A8 (ANXA8) is strongly associated with the basal-like subgroup of breast cancers, including BRCA1-associated breast cancers, and poor prognosis; while in the mouse mammary gland AnxA8 mRNA is expressed in low-pro
Externí odkaz:
https://doaj.org/article/bf01c0a98e5948528c6de9937ed9455a
Autor:
Alan E Bilsland, Katrina Stevenson, Yu Liu, Stacey Hoare, Claire J Cairney, Jon Roffey, W Nicol Keith
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 2, p e1003448 (2014)
Cancer cells depend on transcription of telomerase reverse transcriptase (TERT). Many transcription factors affect TERT, though regulation occurs in context of a broader network. Network effects on telomerase regulation have not been investigated, th
Externí odkaz:
https://doaj.org/article/12af634056c54dc780e056ce775e8e7b
Publikováno v:
Methods in Molecular Biology ISBN: 9781493964734
The epithelium of the pubertal mouse mammary gland grows and invades the mammary fat pad to form a primary ductal network. This outgrowth is tightly controlled by epithelial and stromal factors that are present in the environment around the terminal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7df46809d2b0590973536b32fb707317
https://doi.org/10.1007/978-1-4939-6475-8_6
https://doi.org/10.1007/978-1-4939-6475-8_6
Autor:
Gerard J. Graham, Kenneth Pallas, Kay Hewit, Torsten Stein, Gillian J. Wilson, Claire J. Cairney, Kit Ming Lee, Christopher A.H. Hansell
Publikováno v:
Development (Cambridge, England)
Macrophages are important regulators of branching morphogenesis during development and postnatally in the mammary gland. Regulation of macrophage dynamics during these processes can therefore have a profound impact on development. We demonstrate here
Publikováno v:
Journal of Cellular and Molecular Medicine
Aberrant telomere homeostasis is essential for cell immortality, enabling cells to evade telomere dependent senescence. Disruption of telomere structure and function in cancer cells is highly toxic as shown by detailed pre-clinical evaluation of telo
Autor:
Claire J. Cairney, Alan Bilsland, Sharon Burns, Kyle Lafferty-Whyte, S F Hoare, William Nicol Keith, Nadia Zaffaroni
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 5, Pp 405-414 (2010)
Replicative senescence forms a major barrier to tumor progression. Cancer cells bypass this by using one of the two known telomere maintenance mechanisms: telomerase or the recombination-based alternative lengthening of telomeres (ALT) mechanism. The
Publikováno v:
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease; Vol 1792
Multiple mechanisms of senescence induction exist including telomere attrition, oxidative stress, oncogene expression and DNA damage signalling. The regulation of the cellular changes required to respond to these stimuli and create the complex senesc
Publikováno v:
British Journal of Cancer
Telomere length is maintained by two known mechanisms, activation of telomerase or alternative lengthening of telomeres (ALT). The ALT pathway is more commonly activated in tumours of mesenchymal origin, although the mechanisms involved in the decisi
Autor:
Mahito Sadaie, Christian Dillon, Masashi Narita, Andrew R. J. Young, Claire J. Cairney, Lauren S. Godwin, Christopher J. Torrance, Dorothy C. Bennett, W. Nicol Keith
Publikováno v:
Molecular Biology of the Cell
Compound screening for altered nuclear phenotypes identifies several promiscuous kinase inhibitors that trigger progression of senescence during a polyploid G1. Their common target is AURKB. More-specific inhibition of AURKB phenocopies these compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177765c54f4bb0ab31cb9f10b51ce226
https://eprints.gla.ac.uk/110612/1/110612.pdf
https://eprints.gla.ac.uk/110612/1/110612.pdf