Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Claire Howells"'
Autor:
Shannon Ray, Claire Howells, Emma D Eaton, Chris W Butler, Lana Shabala, Paul A Adlard, Adrian K West, William R Bennett, Gilles J Guillemin, Roger S Chung
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19026 (2011)
BackgroundOne of the key pathological features of AD is the formation of insoluble amyloid plaques. The major constituent of these extracellular plaques is the beta-amyloid peptide (Aβ), although Aβ is also found to accumulate intraneuronally in AD
Externí odkaz:
https://doaj.org/article/9c68d23971814f2ca8bb9aaff0072687
Autor:
Roger S Chung, Claire Howells, Emma D Eaton, Lana Shabala, Kairit Zovo, Peep Palumaa, Rannar Sillard, Adele Woodhouse, William R Bennett, Shannon Ray, James C Vickers, Adrian K West
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12030 (2010)
BACKGROUND: A major pathological hallmark of AD is the deposition of insoluble extracellular beta-amyloid (Abeta) plaques. There are compelling data suggesting that Abeta aggregation is catalysed by reaction with the metals zinc and copper. METHODOLO
Externí odkaz:
https://doaj.org/article/b844c4b59b574b3c8779ab2d2108c6ba
Publikováno v:
FEBS Journal. 277:2931-2939
Neuronal growth-inhibitory factor, later renamed metallothionein-3, is one of four members of the mammalian metallothionein family. Metallothioneins are a family of ubiquitous, low-molecular-weight, cysteine-rich proteins. Although neuronal growth-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6672acd4578356026f5adfd9f75ea016
https://doi.org/10.1111/j.1742-4658.2010.07718.x
https://doi.org/10.1111/j.1742-4658.2010.07718.x
Autor:
Peep Palumaa, Claire Howells, Vello Tõugu, Kairit Zovo, Ann Karafin, Roger S. Chung, Adrian K. West
Publikováno v:
Journal of Neurochemistry. 110:1784-1795
Aggregation of amyloid-beta (Abeta) peptides is a central phenomenon in Alzheimer's disease. Zn(II) and Cu(II) have profound effects on Abeta aggregation; however, their impact on amyloidogenesis is unclear. Here we show that Zn(II) and Cu(II) inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eeb0f573d75b15e22e555f96fb835cc
https://doi.org/10.1111/j.1471-4159.2009.06269.x
https://doi.org/10.1111/j.1471-4159.2009.06269.x
Autor:
Claire Howells, William Bennett, Gilles J. Guillemin, Emma D. Eaton, Lana Shabala, Shannon Ray, Adrian K. West, Roger S. Chung, Peep Palumaa, Paul A. Adlard, Katrina Saar
Publikováno v:
Experimental neurology. 237(2)
Background: The beta-amyloid (Aβ) peptide comprises the amyloid plaques that characterise Alzheimer's disease (AD), and is thought to significantly contribute towards disease pathogenesis. Oxidative stress is elevated in the AD brain, and there is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c959df379fe2326115dd52990ba071b1
https://pubmed.ncbi.nlm.nih.gov/22691462
https://pubmed.ncbi.nlm.nih.gov/22691462
Autor:
Roger S. Chung, Emma D. Eaton, Chris W. Butler, Claire Howells, Lana Shabala, Paul A. Adlard, Gilles J. Guillemin, Adrian K. West, William Bennett, Shannon Ray
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19026 (2011)
PLoS ONE
PLoS ONE
BackgroundOne of the key pathological features of AD is the formation of insoluble amyloid plaques. The major constituent of these extracellular plaques is the beta-amyloid peptide (Aβ), although Aβ is also found to accumulate intraneuronally in AD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b84c6b296bdbbae693aa231b4c8e03d
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21556141/pdf/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21556141/pdf/?tool=EBI
Publikováno v:
The FEBS journal. 277(14)
Neuronal growth-inhibitory factor, later renamed metallothionein-3, is one of four members of the mammalian metallothionein family. Metallothioneins are a family of ubiquitous, low-molecular-weight, cysteine-rich proteins. Although neuronal growth-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7a9321605d4a3ba8fd8a5744564b5c9
https://pubmed.ncbi.nlm.nih.gov/20561053
https://pubmed.ncbi.nlm.nih.gov/20561053
Publikováno v:
Alzheimer's & Dementia. 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0e843c2552ac12710492c24eeeece60
https://doi.org/10.1016/j.jalz.2009.04.1023
https://doi.org/10.1016/j.jalz.2009.04.1023
Autor:
Rannar Sillard, Adele Woodhouse, Claire Howells, Lana Shabala, Adrian K. West, James C. Vickers, Kairit Zovo, Roger S. Chung, William Bennett, Peep Palumaa, Emma D. Eaton, Shannon Ray
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 8, p e12030 (2010)
PLoS ONE, Vol 5, Iss 8, p e12030 (2010)
BACKGROUND: A major pathological hallmark of AD is the deposition of insoluble extracellular beta-amyloid (Abeta) plaques. There are compelling data suggesting that Abeta aggregation is catalysed by reaction with the metals zinc and copper. METHODOLO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97b9435b78a7883ee63d5f5f9b5e8b4
https://doi.org/10.1371/journal.pone.0012030
https://doi.org/10.1371/journal.pone.0012030
Publikováno v:
Molecular Neurodegeneration, Vol 5, Iss 1, p 30 (2010)
Molecular Neurodegeneration
Molecular Neurodegeneration
Background Alzheimer's disease (AD) is a progressive neurodegenerative disease, characterised by the formation of insoluble amyloidogenic plaques and neurofibrillary tangles. Beta amyloid (Aβ) peptide is one of the main constituents in Aβ plaques,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f91927b7b04e9980fd611afaf0e1abf