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pro vyhledávání: '"Claire Holtkamp"'
Autor:
Christina Meyer, Nikhil S. Rao, Suraj S. Vasanthi, Beatriz Pereira, Meghan Gage, Marson Putra, Claire Holtkamp, Joselyn Huss, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Organophosphates (OP) are highly toxic chemical nerve agents that have been used in chemical warfare. Currently, there are no effective medical countermeasures (MCMs) that mitigate the chronic effects of OP exposure. Oxidative stress is a key mechani
Externí odkaz:
https://doaj.org/article/ee60e460bdda414980be652438df1986
Autor:
Christina Meyer, Elizabeth Grego, Suraj S. Vasanthi, Nikhil S. Rao, Nyzil Massey, Claire Holtkamp, Joselyn Huss, Lucas Showman, Balaji Narasimhan, Thimmasettappa Thippeswamy
Publikováno v:
Antioxidants, Vol 12, Iss 12, p 2061 (2023)
NADPH oxidase (NOX) is a primary mediator of superoxides, which promote oxidative stress, neurodegeneration, and neuroinflammation after diisopropylfluorophosphate (DFP) intoxication. Although orally administered mitoapocynin (MPO, 10 mg/kg), a mitoc
Externí odkaz:
https://doaj.org/article/331dd32870e5452ba3ebce96b8785c24