Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Claire Hian Tzer Chan"'
Autor:
Ann Siew Gek Lee, Peter Ang, Yoon Sim Yap, Min-Han Tan, Chui Sheun Yoon, Hai Yang Law, Edward Sern Yuen Wong, Geok Ling Koh, Sau Yeen Loke, Prabhakaran Munusamy, Claire Hian Tzer Chan
Supplementary data contains list of genes and SNP details
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c469b70c2af930856de0a2519b6027
https://doi.org/10.1158/0008-5472.22414409.v1
https://doi.org/10.1158/0008-5472.22414409.v1
Autor:
Ann Siew Gek Lee, Peter Ang, Yoon Sim Yap, Min-Han Tan, Chui Sheun Yoon, Hai Yang Law, Edward Sern Yuen Wong, Geok Ling Koh, Sau Yeen Loke, Prabhakaran Munusamy, Claire Hian Tzer Chan
It has been estimated that >1,000 genetic loci have yet to be identified for breast cancer risk. Here we report the first study utilizing targeted next-generation sequencing to identify single-nucleotide polymorphisms (SNP) associated with breast can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::340547b99988bf8e5dda0b302da2abd2
https://doi.org/10.1158/0008-5472.c.6508967.v1
https://doi.org/10.1158/0008-5472.c.6508967.v1
Publikováno v:
Cellular and Molecular Life Sciences
Reactivation of telomerase is a major hallmark observed in 90% of all cancers. Yet paradoxically, enhanced telomerase activity does not correlate with telomere length and cancers often possess short telomeres; suggestive of supplementary non-canonica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538e825fdd63bbbc6c3c5acb3576e7f1
http://europepmc.org/articles/PMC8164586
http://europepmc.org/articles/PMC8164586
Autor:
Semih Can Akıncılar, Joelle Yi Heng Chua, Qin Feng Ng, Claire Hian Tzer Chan, Zahra Eslami-S, Kaijing Chen, Joo-Leng Low, Surendar Arumugam, Luay Aswad, Clarinda Chua, Iain Beehuat Tan, Ramanuj DasGupta, Melissa Jane Fullwood, Vinay Tergaonkar
Publikováno v:
Nucleic acids research.
Transcriptional reactivation of hTERT is the limiting step in tumorigenesis. While mutations in hTERT promoter present in 19% of cancers are recognized as key drivers of hTERT reactivation, mechanisms by which wildtype hTERT (WT-hTERT) promoter is re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b58bc6f7687976a8b1c08836ea43d43
https://pubmed.ncbi.nlm.nih.gov/35697349
https://pubmed.ncbi.nlm.nih.gov/35697349
Autor:
Claire Hian Tzer Chan, Prabhakaran Munusamy, Sau Yeen Loke, Geok Ling Koh, Audrey Zhi Yi Yang, Hai Yang Law, Chui Sheun Yoon, Chow Yin Wong, Wei Sean Yong, Nan Soon Wong, Raymond Chee Hui Ng, Kong Wee Ong, Preetha Madhukumar, Chung Lie Oey, Gay Hui Ho, Puay Hoon Tan, Min Han Tan, Peter Ang, Yoon Sim Yap, Ann Siew Gek Lee
Publikováno v:
Oncotarget
// Claire Hian Tzer Chan 1, * , Prabhakaran Munusamy 1, * , Sau Yeen Loke 1 , Geok Ling Koh 1 , Audrey Zhi Yi Yang 1 , Hai Yang Law 2 , Chui Sheun Yoon 2 , Chow Yin Wong 3 , Wei Sean Yong 4 , Nan Soon Wong 5, 6 , Raymond Chee Hui Ng 5 , Kong Wee Ong
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2678ddb442c50d3ee9c4d358e161c998
https://doi.org/10.18632/oncotarget.24374
https://doi.org/10.18632/oncotarget.24374
Autor:
Ann Siew Gek Lee, Geok Ling Koh, Min-Han Tan, Edward Sern Yuen Wong, Prabhakaran Munusamy, Hai-Yang Law, Claire Hian Tzer Chan, Chui Sheun Yoon, Peter Ang, Yoon Sim Yap, Sau Yeen Loke
Publikováno v:
Cancer Research. 77:5428-5437
It has been estimated that >1,000 genetic loci have yet to be identified for breast cancer risk. Here we report the first study utilizing targeted next-generation sequencing to identify single-nucleotide polymorphisms (SNP) associated with breast can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00bd6c7c535227f45daa5a059af76b8
https://doi.org/10.1158/0008-5472.can-17-0992
https://doi.org/10.1158/0008-5472.can-17-0992
Autor:
Chung Lie Oey, Ann Siew Gek Lee, Su Lin Jill Wong, Prabhakaran Munusamy, Jee Liang Thung, Geok Ling Koh, Choon Hua Thng, Sue Zann Lim, Mun Yew Patrick Chan, Sau Yeen Loke, Kong Wee Ong, Claire Hian Tzer Chan, Yirong Sim, Veronique Kiak Mien Tan, Bee Kiang Chong, Boon Kheng James Khoo, Ern Yu Tan, Wei Sean Yong, Teng Swan Juliana Ho, Preetha Madhukumar, Kiat Tee Benita Tan
Publikováno v:
Cancers
Volume 11
Issue 12
Volume 11
Issue 12
Although mammography is the gold standard for breast cancer screening, the high rates of false-positive mammograms remain a concern. Thus, there is an unmet clinical need for a non-invasive and reliable test to differentiate between malignant and ben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d658076cda70e8af5268dc5811cc0bb
Autor:
Peter Ang, Jimin Yuan, Min-Han Tan, Aldo Prawira, Yoon Sim Yap, Prabhakaran Munusamy, Timothy Wai Ho Shuen, Claire Hian Tzer Chan, Ann Siew Gek Lee, Geok Ling Koh, Jiancheng Hu
Publikováno v:
Breast cancer research and treatment. 177(1)
PARP4 has been proposed as a candidate breast cancer susceptibility gene. However, its function and involvement in breast carcinogenesis is unclear. We sought to determine the variant frequency of PARP4 in BRCA-negative women referred for genetic tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eebae296855841bef921c14ada62b79d
https://pubmed.ncbi.nlm.nih.gov/31119570
https://pubmed.ncbi.nlm.nih.gov/31119570
Autor:
Aye-Aye Thike, Cindy Lim, Puay Hoon Tan, Sau Yeen Loke, David F. Callen, Yoon Sim Yap, Iain Beehuat Tan, Ann S. G. Lee, Jeffrey Chun Tatt Lim, Swee-Ho Lim, Claire Hian Tzer Chan, Aldo Prawira, Sarah B. H. Ng, Prabhakaran Munusamy, Kong-Wee Ong, Wei-Sean Yong
Publikováno v:
Breast cancer research and treatment. 171(3)
The purpose of the study was to improve the understanding of NF1-associated breast cancer, given the increased risk of breast cancer in this tumour predisposition syndrome and the limited data. We identified 18 women with NF1 and breast cancer at our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd77fb30b30c09f3a70f85f2a46eaa2
https://pubmed.ncbi.nlm.nih.gov/29926297
https://pubmed.ncbi.nlm.nih.gov/29926297
Autor:
Marie Met-Domestici, Yoon Sim Yap, Ann S. G. Lee, Peter Ang, Sandhya Shekar, Melody Sze, Steven G. Rozen, Edward Sern Yuen Wong, Joanne Ngeow, Claire Hian Tzer Chan, Min-Han Tan
Publikováno v:
NPJ Genomic Medicine
Genetic testing for germline mutations in breast cancer predisposition genes can potentially identify individuals at a high risk of developing breast and/or ovarian cancer. There is a paucity of such mutational information for Asians. Panel testing o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6901949dea62f779b6c569462aa59b3b
https://doi.org/10.1038/npjgenmed.2015.3
https://doi.org/10.1038/npjgenmed.2015.3