Výsledky vyhledávání - "Claire H Hearnden"

Akademický článek

Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection.

Autor: Aisling F Brown, Alison G Murphy, Stephen J Lalor, John M Leech, Kate M O'Keeffe, Micheál Mac Aogáin, Dara P O'Halloran, Keenan A Lacey, Mehri Tavakol, Claire H Hearnden, Deirdre Fitzgerald-Hughes, Hilary Humphreys, Jérôme P Fennell, Willem J van Wamel, Timothy J Foster, Joan A Geoghegan, Ed C Lavelle, Thomas R Rogers, Rachel M McLoughlin

Publikováno v: PLoS Pathogens, Vol 11, Iss 11, p e1005226 (2015)

Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain elusive. While the importance of cellular immunity has been shown in mice, T cell responses in humans have not been characterised. Using a murine model of recurrent

Externí odkaz: https://doaj.org/article/6832261a8fdf4af4abe77367d6c1163a

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Akademický článek

Multivalent presentation of MPL by porous silicon microparticles favors T helper 1 polarization enhancing the anti-tumor efficacy of doxorubicin nanoliposomes.

Autor: Ismail M Meraz, Claire H Hearnden, Xuewu Liu, Marie Yang, Laura Williams, David J Savage, Jianhua Gu, Jessica R Rhudy, Kenji Yokoi, Ed C Lavelle, Rita E Serda

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94703 (2014)

Porous silicon (pSi) microparticles, in diverse sizes and shapes, can be functionalized to present pathogen-associated molecular patterns that activate dendritic cells. Intraperitoneal injection of MPL-adsorbed pSi microparticles, in contrast to free

Externí odkaz: https://doaj.org/article/8b0a491297a041a28c2204de4e4160c3

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Modulation of Immune Responses by Particulate Materials

Autor: Filipa Lebre, Ed C. Lavelle, Claire H. Hearnden

Publikováno v: Advanced Materials. 28:5525-5541

Many biomaterials that are in both preclinical and clinical use are particulate in nature and there is a growing appreciation that the physicochemical properties of materials have a significant impact on their efficacy. The ability of particulates to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c4fd4960e905f7e0f274186a5d1cd8
https://doi.org/10.1002/adma.201505395

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IL-1α and inflammasome-independent IL-1β promote neutrophil infiltration following alum vaccination

Autor: Graham Coutts, Claire H. Hearnden, Ed C. Lavelle, Stuart M. Allan, Hannah B.T. Moran, Christopher J. Scott, Matthew Campbell, Ewa Oleszycka, Graham A. Tynan

Publikováno v: FEBS Journal. 283:9-24

Despite its long record of successful use in human vaccines, the mechanisms underlying the immunomodulatory effects of alum are not fully understood. Alum is a potent inducer of interleukin-1 (IL-1) secretion in vitro in dendritic cells and macrophag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9c10542b36c738817becebd2fe699d
https://doi.org/10.1111/febs.13546

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Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1α–Dependent Inflammation

Autor: Ed C. Lavelle, Graham A. Tynan, Kenneth Hun Mok, Justin Geoghegan, Graham Coutts, Lydia Lynch, Ewa Oleszycka, Stuart M. Allan, Cliona O'Farrelly, Michelle Corrigan, Claire L. Lyons, John J. Callanan, Donal O'Shea, Helen M. Roche, Jean O'Connell, Matthew Campbell, Claire H. Hearnden

Publikováno v: Diabetes. 63:2037-2050

Obesity is characterized by chronic inflammation associated with neutrophil and M1 macrophage infiltration into white adipose tissue. However, the mechanisms underlying this process remain largely unknown. Based on the ability of oil-based adjuvants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5bd793bbe3259845971435bbd46832
https://doi.org/10.2337/db13-1476

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Autophagy Regulates IL-23 Secretion and Innate T Cell Responses through Effects on IL-1 Secretion

Autor: Ed C. Lavelle, Laura Williams, Cliona Ni Cheallaigh, Claire H. Hearnden, Sarah Jones, Celia Peral de Castro, James Harris, Jan Winter, Kingston H. G. Mills

Publikováno v: The Journal of Immunology. 189:4144-4153

Autophagy controls IL-1β secretion by regulating inflammasome activation and by targeting pro–IL-1β for degradation. In this article, we show that inhibition of autophagy, either with the PI3K inhibitors 3-methyladenine, wortmannin, and LY294002

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02a9b0e352105920db63cf5c56f3a81
https://doi.org/10.4049/jimmunol.1201946

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