Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Claire Guyomard"'
Autor:
Benjamin Fremond, Christine Malandain, Claire Guyomard, Christophe Chesne, André Guillouzo, Jean-Pierre Campion
Publikováno v:
Cell Transplantation, Vol 2 (1993)
A new extracorporeal bioartificial liver using alginate-entrapped hepatocytes was developed and evaluated for its ability to correct the lack of bilirubin conjugation in the Gunn rat. Hepatocytes were harvested from Sprague-Dawley rats by the two-ste
Externí odkaz:
https://doaj.org/article/fbb9cfe6c9724ade9e28fc4503517a5a
Autor:
Josette Lucas, Christiane Guguen-Guillouzo, Stephan Urban, Jacques Le Seyec, Isabelle Cannie, Christian Trepo, Sylvie Rumin, Philippe Gripon, Denise Glaise, Claire Guyomard
Publikováno v:
Proceedings of the National Academy of Sciences. 99:15655-15660
Among numerous established human hepatoma cell lines, none has been shown susceptible to hepatitis B virus (HBV) infection. We describe here a cell line, called HepaRG, which exhibits hepatocyte-like morphology, expresses specific hepatocyte function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e90ff3bef41a1c91edc4f228a26bdc
https://doi.org/10.1073/pnas.232137699
https://doi.org/10.1073/pnas.232137699
Publikováno v:
Chemico-Biological Interactions. 121:7-16
Cryopreservation in liquid nitrogen is presently the only way for long-term storage of isolated hepatocytes. Freeze–thaw conditions are not well defined yet; the most critical parameters appear to be the choice of the cryoprotectant, composition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5296bbd32691e7c7e10e71e9b94023
https://doi.org/10.1016/s0009-2797(99)00087-3
https://doi.org/10.1016/s0009-2797(99)00087-3
Autor:
Martine Aggerbeck, J Bouguet, Claire Guyomard, Philippe Costet, Christiane Legendre, Alan D Edgar, Céline Tomkiewicz, Bart Staels, Thierry Pineau, Robert Barouki
Publikováno v:
Toxicology Letters. 98:13-23
Fibrates modify the expression of genes implicated in lipoprotein and fatty acid metabolism via the peroxisome proliferator-activated receptor alpha(PPARalpha), leading to reductions in serum triglycerides and cholesterol. The expression of certain g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771965f57b52dcfcb8066fb0c206551b
https://doi.org/10.1016/s0378-4274(98)00042-3
https://doi.org/10.1016/s0378-4274(98)00042-3
Publikováno v:
Xenobiotica. 28:1-13
1. The metabolism of Meloxicam (ME) and the cytochrome(s) P450 (CYPs) involved were analysed by using primary human hepatocytes, human liver microsomes and microsomes from recombinant human B-lymphoblastoid cell lines. 2. While human hepatocytes were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1140edc950eb67bcc7c4918b8e36482d
https://doi.org/10.1080/004982598239704
https://doi.org/10.1080/004982598239704
Publikováno v:
Toxicology and Applied Pharmacology. 141:349-356
Rat hepatocytes immobilized in calcium-alginate beads were tested for their ability to survive and function in vitro by comparison with hepatocyte monolayer cultures before and after cryopreservation. The freeze-thaw protocol previously designed for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f8544441467bb064be383d2c7632ee7
https://doi.org/10.1006/taap.1996.0299
https://doi.org/10.1006/taap.1996.0299
Autor:
Christophe Chesne, André Guillouz, Marie-gwenaëlle Poullain, Alain Fautrel, Benjamin Fremond, Claire Guyomard, Hendrik de Jong
Publikováno v:
Hepatology. 18:406-414
Cryopreserved hepatocytes from various animal species and human beings were tested for their ability to survive and function in primary culture. The freeze/thaw protocol primarily designed for rat hepatocytes was used with slight modifications for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed0be5330236b613793505d618f96cf
https://doi.org/10.1002/hep.1840180227
https://doi.org/10.1002/hep.1840180227
Publikováno v:
Toxicology in Vitro. 5:479-482
To evaluate the potential use of cryopreserved hepatocytes for toxicological studies, rat, dog and human hepatocytes were frozen in Leibovitz medium containing 20% foetal calf serum and various concentrations of dimethylsulphoxide and stored in liqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d156c3bcc8998f16ddac5eb15c7c648
https://doi.org/10.1016/0887-2333(91)90076-p
https://doi.org/10.1016/0887-2333(91)90076-p
Autor:
Robert Heavens, Bindi Sohal, Christine Pattison, Georgina Meneses-Lorente, Claire Guyomard, Alan P. Watt, Christophe Chesne
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 35(2)
Cytochrome P450 (P450) induction may have considerable implications for drug therapy. Therefore, understanding the induction potential of a new chemical entity at an early stage in discovery is crucial to reduce the risk of failure in the clinic and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c1f0e66d078a80f1d193b048ac417d
https://pubmed.ncbi.nlm.nih.gov/17093007
https://pubmed.ncbi.nlm.nih.gov/17093007
Publikováno v:
Mutation research. 519(1-2)
Liverbeads, cryopreserved hepatocytes entrapped within an alginate matrix, were examined for their relevance in the comet assay. It was estimated by their capacity to activate the indirectly acting mutagens, cyclophosphamide (CP), benzo[a]pyrene (BP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c9a669cd72bf2de2c495b09c756ad8
https://pubmed.ncbi.nlm.nih.gov/12160901
https://pubmed.ncbi.nlm.nih.gov/12160901