Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Claire Goldsbury"'
Autor:
Fabia Filipello, Claire Goldsbury, Shih Feng You, Alberto Locca, Celeste M. Karch, Laura Piccio
Publikováno v:
Neurobiology of Disease, Vol 165, Iss , Pp 105630- (2022)
Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor expressed by macrophages and microglia in the central nervous system (CNS). TREM2 has attracted a lot of interest in the past decade for its critical role in modula
Externí odkaz:
https://doaj.org/article/e244266022764600b040bf1e47ecf59f
Publikováno v:
Free Neuropathology, Vol 1, Pp 20-20 (2020)
Alzheimer’s disease (AD) is a late-onset disease that has proved difficult to model. Microglia are implicated in AD, but reports vary on precisely when and how in the sequence of pathological changes they become involved. Here, post-mortem human ti
Externí odkaz:
https://doaj.org/article/33ad1ae64fde4ad39e8b47e71d960ef4
Autor:
Jamie R. Acosta, Maxinne Watchon, Kristy C. Yuan, Jennifer A. Fifita, Adam J. Svahn, Emily K. Don, Claire G. Winnick, Ian P. Blair, Garth A. Nicholson, Nicholas J. Cole, Claire Goldsbury, Angela S. Laird
Publikováno v:
Biology Open, Vol 7, Iss 10 (2018)
We describe a protocol for culturing neurons from transgenic zebrafish embryos to investigate the subcellular distribution and protein aggregation status of neurodegenerative disease-causing proteins. The utility of the protocol was demonstrated on c
Externí odkaz:
https://doaj.org/article/0f9782bd2e3e47418a35208188f6cfb8
Autor:
Jamie Rae Acosta, Claire Goldsbury, Claire Winnick, Andrew P Badrock, Stuart T Fraser, Angela S Laird, Thomas E Hall, Emily K Don, Jennifer A Fifita, Ian P Blair, Garth A Nicholson, Nicholas J Cole
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e90572 (2014)
FUS mutations can occur in familial amyotrophic lateral sclerosis (fALS), a neurodegenerative disease with cytoplasmic FUS inclusion bodies in motor neurons. To investigate FUS pathology, we generated transgenic zebrafish expressing GFP-tagged wild-t
Externí odkaz:
https://doaj.org/article/2310ea556cbd4b9d9e565e5e97d0b6ed
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20878 (2011)
Abnormal mitochondrial function is a widely reported contributor to neurodegenerative disease including Alzheimer's disease (AD), however, a mechanistic link between mitochondrial dysfunction and the initiation of neuropathology remains elusive. In A
Externí odkaz:
https://doaj.org/article/caa0293bbf49422ea569b944d1c7af7e
Autor:
Thuvarahan Jegathees, Glib Popov, Claire Goldsbury, Monica Vogiatzis, Patricia O. Banaczek, Gurpreet Kaur Hansra, Karen M. Cullen
Publikováno v:
Neurobiology of Aging. 82:88-101
Cerebrovascular pathology is common in aging and Alzheimer's disease (AD). The microvasculature is particularly vulnerable, with capillary-level microhemorrhages coinciding with amyloid beta deposits in senile plaques. In the current analysis, we ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d552703985c62d6c04c6c79301526e0
https://doi.org/10.1016/j.neurobiolaging.2019.06.009
https://doi.org/10.1016/j.neurobiolaging.2019.06.009
Publikováno v:
Brain Pathology. 27:795-808
Changes in microglia function are involved in Alzheimer's disease (AD) for which ageing is the major risk factor. We evaluated microglial cell process morphologies and their gray matter coverage (arborized area) during ageing and in the presence and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02a298937ce08e56032d959f3e576a25
https://doi.org/10.1111/bpa.12456
https://doi.org/10.1111/bpa.12456
Autor:
Claire Goldsbury, Greg T. Sutherland, Patrick Jarmo Paasila, Danielle S. Davies, Jillian J. Kril
Publikováno v:
Brain Pathol
Microglial associations with both the major Alzheimer's disease (AD) pathognomonic entities, β-amyloid-positive plaques and tau-positive neurofibrillary tangles, have been noted in previous investigations of both human tissue and mouse models. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af51d027f4d3d3461948e99593bd33c7
https://europepmc.org/articles/PMC8028288/
https://europepmc.org/articles/PMC8028288/
Publikováno v:
Journal of Structural Biology. 195:345-352
Alzheimer’s disease (AD) involves the propagation of filaments of tau protein throughout the cerebral cortex. Imaging tau filaments and oligomers in human brain at high resolution would help contribute insight into the mechanism and progression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60dca227af3a8d31a17b2f5b75bb50a4
https://doi.org/10.1016/j.jsb.2016.07.003
https://doi.org/10.1016/j.jsb.2016.07.003
Autor:
Ian P. Blair, Nicholas J. Cole, Kristy C. Yuan, Adam J. Svahn, Claire Goldsbury, Claire Winnick, Angela S. Laird, Garth A. Nicholson, Jamie Rae Acosta, Emily K. Don, Maxinne Watchon, Jennifer A. Fifita
Publikováno v:
Biology Open, Vol 7, Iss 10 (2018)
Biology Open
Biology Open
We describe a protocol for culturing neurons from transgenic zebrafish embryos to investigate the subcellular distribution and protein aggregation status of neurodegenerative disease-causing proteins. The utility of the protocol was demonstrated on c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2eb6732eb686cfadbc37a653c2bdf8
http://bio.biologists.org/content/7/10/bio036475
http://bio.biologists.org/content/7/10/bio036475