HtrA1 Inhibits Mineral Deposition by Osteoblasts

Autor: Ann E. Canfield, Kristen D. Hadfield, Laure Sudre, Sarah L. Dallas, Claire Farrington Rock, Raymond P. Boot-Handford, Gillian A. Wallis, Colette A. Inkson

Publikováno v: Journal of Biological Chemistry. 283:5928-5938

HtrA1 is a secreted multidomain protein with serine protease activity. In light of increasing evidence implicating this protein in the regulation of skeletal development and pathology, we investigated the role of HtrA1 in osteoblast mineralization an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8e150a784af8e6af765602131647c18
https://doi.org/10.1074/jbc.m709299200

Bisindolylmaleimide I Suppresses Fibroblast Growth Factor-mediated Activation of Erk MAP Kinase in Chondrocytes by Preventing Shp2 Association with the Frs2 and Gab1 Adaptor Proteins

Autor: Bernard Masri, Leslie M. Thompson, William R. Wilcox, Claire Farrington-Rock, Pavel Krejci, Lisa Salazar, Hervé Prats

Publikováno v: Journal of Biological Chemistry. 282:2929-2936

Fibroblast growth factors (FGFs) inhibit chondrocyte proliferation via the Erk MAP kinase pathway. Here, we explored the role of protein kinase C in FGF signaling in chondrocytes. Erk activity in FGF2-treated RCS (rat chondrosarcoma) chondrocytes or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83cfbd231e761da92991ff5d0faab080
https://doi.org/10.1074/jbc.m606144200

Identification and Characterization of Vascular Calcification–Associated Factor, a Novel Gene Upregulated During Vascular Calcification In Vitro and In Vivo

Autor: Fiona L. Wilkinson, Claire Farrington Rock, J. Vincent Smyth, Anthony M. Heagerty, M. Yvonne Alexander, Ann E. Canfield, Georgina D.M. Collett, John Paul Kirton, Maria Jeziorska

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 25:1851-1857

Objective— Vascular calcification, with its increasing clinical sequelae, presents an important and unresolved dilemma in cardiac and vascular practice. We aimed to identify molecules involved in this process to develop strategies for treatment or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb56b6e8870a67d0bd4616808e87b1ae
https://doi.org/10.1161/01.atv.0000175750.94742.46

Disruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synostosis syndrome

Autor: Claire Farrington-Rock, Matthew J. Rock, Veneta T. Kirilova, Deborah Krakow, Lisa Dillard-Telm, Alexander D. Borowsky, Daniel H. Cohn, Sara Chalk

Publikováno v: Human molecular genetics. 17(5)

Spondylocarpotarsal synostosis syndrome (SCT) is an autosomal recessive disease that is characterized by short stature, and fusions of the vertebrae and carpal and tarsal bones. SCT results from homozygosity or compound heterozygosity for nonsense mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3bc113d5cea7ed075ccaf686c18335
https://pubmed.ncbi.nlm.nih.gov/17635842

A molecular and clinical study of Larsen syndrome caused by mutations in FLNB

Autor: Louise S. Bicknell, Paolo Prontera, Patrick Rump, Yousef Shafeghati, Deborah Krakow, Stephen P. Robertson, Alan Fryer, Louise C. Wilson, Sheila Unger, Jean-Pierre Fryns, Chong Ae Kim, John Pappas, Helen V. Firth, David L. Rimoin, Claire Farrington-Rock, Ellen Moran, Yasemin Alanay, Daniel H. Cohn, Thomy de Ravel, Melissa Maisenbacher, Elizabeth Sweeney, Ralph S. Lachman, Yves Alembik, Kathryn Leask, Mohammad Hassan Kariminejad, Navid Al-Madani

Publikováno v: JOURNAL OF MEDICAL GENETICS, 44(2), 89-98. BMJ PUBLISHING GROUP
Bicknell, L S, Farrington-Rock, C, Shafeghati, Y, Rump, P, Alanay, Y, Alembik, Y, Al-Madani, N, Firth, H, Karimi-Nejad, M H, Kim, C A, Leask, K, Maisenbacher, M, Moran, E, Pappas, J G, Prontera, P, de Ravel, T, Fryns, J-P, Sweeney, E, Fryer, A, Unger, S, Wilson, L C, Lachman, R S, Rimoin, D L, Cohn, D H, Krakow, D & Robertson, S P 2007, ' A molecular and clinical study of Larsen syndrome caused by mutations in FLNB ', Journal of Medical Genetics, vol. 44, no. 2, pp. 89-98 . https://doi.org/10.1136/jmg.2006.043687

Background: Larsen syndrome is an autosomal dominant osteochondrodysplasia characterised by large-joint dislocations and craniofacial anomalies. Recently, Larsen syndrome was shown to be caused by missense mutations or small inframe deletions in FLNB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11d63a7f2e31be9ed58ff20b5d868bd
https://research.rug.nl/en/publications/9979a21c-a190-4254-960f-7e6348454df3