Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Claire E. McCoy"'
Autor:
Stephen Fitzsimons, María Muñoz-San Martín, Frances Nally, Eugene Dillon, Ifeolutembi A. Fashina, Moritz J. Strowitzki, Lluís Ramió-Torrentà, Jennifer K. Dowling, Chiara De Santi, Claire E. McCoy
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 941-959 (2023)
The modulation of macrophage phenotype from a pro-inflammatory to an anti-inflammatory state holds therapeutic potential in the treatment of inflammatory disease. We have previously shown that arginase-2 (Arg2), a mitochondrial enzyme, is a key regul
Externí odkaz:
https://doaj.org/article/1357adafc21b460497babab7bfbd80f7
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-16 (2023)
Abstract Background Genome-wide association studies (GWAS) have highlighted over 200 autosomal variants associated with multiple sclerosis (MS). However, variants in non-coding regions such as those encoding microRNAs have not been explored thoroughl
Externí odkaz:
https://doaj.org/article/4812792daf64487cbc529f87755aef41
Autor:
Chiara De Santi, Frances K. Nally, Remsha Afzal, Conor P. Duffy, Stephen Fitzsimons, Stephanie L. Annett, Tracy Robson, Jennifer K. Dowling, Sally-Ann Cryan, Claire E. McCoy
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 643-655 (2022)
Macrophages are plastic cells playing a crucial role in innate immunity. While fundamental in responding to infections, when persistently maintained in a pro-inflammatory state they can initiate and sustain inflammatory diseases. Therefore, a strateg
Externí odkaz:
https://doaj.org/article/ae3ff2c8f1cd481ead6fd54d5a844dba
Autor:
Glenn Fitzpatrick, Danielle Nader, Rebecca Watkin, Claire E. McCoy, Gerard F. Curley, Steven W. Kerrigan
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
The pathophysiology of sepsis and its accompanying hyper-inflammatory response are key events that lead to multi-organ failure and death. A growing body of literature now suggests that the vascular endothelium plays a critical role in driving early e
Externí odkaz:
https://doaj.org/article/7d1ac8e2372648d5bb59257b065d9182
Autor:
Jennifer K. Dowling, Remsha Afzal, Linden J. Gearing, Mariana P. Cervantes-Silva, Stephanie Annett, Gavin M. Davis, Chiara De Santi, Nadine Assmann, Katja Dettmer, Daniel J. Gough, Glenn R. Bantug, Fidinny I. Hamid, Frances K. Nally, Conor P. Duffy, Aoife L. Gorman, Alex M. Liddicoat, Ed C. Lavelle, Christoph Hess, Peter J. Oefner, David K. Finlay, Gavin P. Davey, Tracy Robson, Annie M. Curtis, Paul J. Hertzog, Bryan R. G. Williams, Claire E. McCoy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
IL-10 can limit inflammation in part by inhibiting miR-155. Here the authors show how this axis induces mitochondrial arginase-2 to alter the mitochondrial dynamics and bioenergetics of macrophages and make these cells less pro-inflammatory.
Externí odkaz:
https://doaj.org/article/fa68c802cf994295ba5c37913f6eb977
Autor:
Adrian Dervan, Antonio Franchi, Francisco R. Almeida-Gonzalez, Jennifer K. Dowling, Ohemaa B. Kwakyi, Claire E. McCoy, Fergal J. O’Brien, Alan Hibbitts
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2161 (2021)
Injury to the peripheral or central nervous systems often results in extensive loss of motor and sensory function that can greatly diminish quality of life. In both cases, macrophage infiltration into the injury site plays an integral role in the hos
Externí odkaz:
https://doaj.org/article/b6660bccd3a54e7ab924bd89e7ac282f
Autor:
Conor P. Duffy, Claire E. McCoy
Publikováno v:
Cells, Vol 9, Iss 7, p 1711 (2020)
Multiple sclerosis (MS) is an autoimmune disorder characterised by demyelination of central nervous system neurons with subsequent damage, cell death and disability. While mechanisms exist in the CNS to repair this damage, they are disrupted in MS an
Externí odkaz:
https://doaj.org/article/18cd8e08460c426b8be6c63426012bb5
Publikováno v:
Cells, Vol 8, Iss 6, p 543 (2019)
Multiple Sclerosis (MS) is a chronic demyelinating autoimmune disease primarily affecting young adults. Despite an unclear causal factor, symptoms and pathology arise from the infiltration of peripheral immune cells across the blood brain barrier. Ac
Externí odkaz:
https://doaj.org/article/3b80fba79b694654867e907155cf2a56
Autor:
Yong Ni, Thomas A. Kent, Hui-Ling Zhang, Chao Wei, Zhan-Xiang Wang, Claire E. McCoy, Yi Guo, Yong-Ming Zhu, Xian-Yong Zhou, Yuan Qin, Liang Lin, Zhong-Sheng Li
Publikováno v:
Translational Stroke Research
Graphical Abstract Necroptosis initiation relies on the receptor-interacting protein 1 kinase (RIP1K). We recently reported that genetic and pharmacological inhibition of RIP1K produces protection against ischemic stroke-induced astrocytic injury. Ho
Autor:
Devika Dahiya, Jonathan Smith, Tammy Strickland, Delphi Morris, Cristina Reschke, Tobias Engel, David Henshall, Claire E McCoy, Jennifer K Dowling
Publikováno v:
BioRxiv the preprint server for Biology
bioRxiv
bioRxiv
Hypoxic ischaemic injury (HIE) in the neonatal brain has significant consequences on neurodevelopment and increases the occurrence of neurological deficits in infants. HIE is also a leading cause of neonatal seizures. Therapeutic options for the trea