Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Claire E. Madden-Smith"'
Autor:
Andrew Parker, Jakob Sloth, Clive J. Roberts, Claire E. Madden-Smith, Nikin Patel, Jesper Jensen, Paul T. Whiteside, Jianxin Zhang
Publikováno v:
International Journal of Pharmaceutics. 455:306-311
When assessing the suitability of potential drug/polymer systems for improving drug bioavailability, substantial efficiency gains can be achieved through the development and application of rapid miniaturised screening methods. For this to be possible
Autor:
Claire E. Madden-Smith, Matthew Bunker, Nikin Patel, Jianxin Zhang, Clive J. Roberts, Andrew Parker
Publikováno v:
International Journal of Pharmaceutics. 414:210-217
Nanothermal analysis (NTA) supported by atomic force microscopy imaging has been used to study the changes that occur at the surfaces of solid dispersions of the drug felodipine and the water soluble polymer, polyvinylpyrrolidone (PVP) on exposure to
Autor:
Robert E. Johnson, Claire E. Madden-Smith, Delphine Le Roux, Saleem S. Ahmed, Dirk L. Teagarden, David O. Bates, S Rigby-Singleton, Lavinia M. Lewis, Mark Perkins, Andrew Parker, Clive J. Roberts
Publikováno v:
Journal of Pharmaceutical Sciences. 99:4616-4629
This work investigated the impact of primary drying conditions on the microstructure and protein stability of bovine serum albumin (BSA) containing lyophilized cakes. Two primary drying conditions were employed (termed ‘conservative’, slower dryi
Autor:
Nikin Patel, S Rigby-Singleton, Claire E. Madden-Smith, Jeff James, J. Ledru, Shen Y. Luk, Clive J. Roberts, Mark Perkins, Matt Bunker
Publikováno v:
European Journal of Pharmaceutical Sciences. 38:1-8
In this study we aim to explore the potential links between the mechanical properties, micronisation behaviour and surface energy of carbamazepine polymorphs using atomic force microscopy (AFM) measurements of material properties at the nanoscale. Ca
Autor:
Michael W. George, Nikin Patel, Paul Turner, Shen Y. Luk, Claire E. Madden-Smith, Paul T. Whiteside
Publikováno v:
Pharmaceutical Research. 25:2650-2656
To demonstrate the potential of monitoring H/D exchange by FT-Raman spectroscopy as a tool for the detection and quantification of low levels of amorphous lactose in formulations.Samples containing different proportions of amorphous and crystalline l