Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Claire E. Jennings"'
Autor:
Sabrina Wamp, Zoe J Rutter, Jeanine Rismondo, Claire E Jennings, Lars Möller, Richard J Lewis, Sven Halbedel
Publikováno v:
eLife, Vol 9 (2020)
Peptidoglycan (PG) is the main component of bacterial cell walls and the target for many antibiotics. PG biosynthesis is tightly coordinated with cell wall growth and turnover, and many of these control activities depend upon PASTA-domain containing
Externí odkaz:
https://doaj.org/article/1c1d44765c49471f9399ff1fa5d7f7f1
Autor:
Lan Z. Wang, Miller Duncan Charles, Bernard T. Golding, Ian Hickson, Martin E.M. Noble, Celine Cano, Suzannah J. Harnor, Michael J. Waring, Harry J Shrives, Shaimaa Khalifa, Jane Totobenazara, Stephen J. Hobson, Elaine Willmore, Hannah L Stewart, Mathew P. Martin, Susan J. Tudhope, Huw D. Thomas, Islam Al-Khawaldeh, Claire E. Jennings, João V de Souza, Max J. Temple, Jane A. Endicott, Cinzia Bordoni, Honorine Lebraud, Agnieszka K. Bronowska, Ian R. Hardcastle, Amy B. Heptinstall, Stephen R. Wedge, Christine Basmadjian, Gregory G Aldred, Julie A. Tucker, Mohammed J Al Yasiri
Publikováno v:
Journal of Medicinal Chemistry. 64:10001-10018
NF-κB-inducing kinase (NIK) is a key enzyme in the noncanonical NF-κB pathway, of interest in the treatment of a variety of diseases including cancer. Validation of NIK as a drug target requires potent and selective inhibitors. The protein contains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56300566066f33b5e78d20a96b537040
https://doi.org/10.1021/acs.jmedchem.0c01249
https://doi.org/10.1021/acs.jmedchem.0c01249
Autor:
Benoit Carbain, Keisha Hearn, Ildiko Maria Buck, Burcu Anil, Sarah J. Cully, Gianni Chessari, Jane A. Endicott, John Lunec, Neil T. Thompson, Juan Castro, Roger J. Griffin, Rhian S. Holvey, Karen Haggerty, Charlotte H. Revill, Ruth H. Bawn, Stephen R. Wedge, Christiane Riedinger, Christopher N. Johnson, Bernard T. Golding, Lynsey Fazal, Ian R. Hardcastle, Mladen Vinkovic, Claire E. Jennings, Jong Sook Ahn, Bian Zhang, Pamela A. Williams, Celine Cano, Suzannah J. Harnor, Ben Cons, Stephen J. Hobson, E. Anscombe, Jeffrey D. St. Denis, Steven Howard, David R. Newell, Emiliano Tamanini, Nicola E. Wilsher, Miller Duncan Charles, Huw D. Thomas, Timothy J. Blackburn, Martin E.M. Noble, Judith Reeks, Yan Zhao, Luke Bevan
Publikováno v:
Journal of Medicinal Chemistry. 64:4071-4088
Inhibition of murine double minute 2 (MDM2)-p53 protein-protein interaction with small molecules has been shown to reactivate p53 and inhibit tumor growth. Here, we describe rational, structure-guided, design of novel isoindolinone-based MDM2 inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2c962765a3d64c4d7d02d50fd31b0d
https://doi.org/10.1021/acs.jmedchem.0c02188
https://doi.org/10.1021/acs.jmedchem.0c02188
Autor:
Sven Halbedel, Jeanine Rismondo, Zoe J. Rutter, Richard J. Lewis, Sabrina Wamp, Lars Moeller, Claire E. Jennings
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Peptidoglycan (PG) is the main component of bacterial cell walls and the target for many antibiotics. PG biosynthesis is tightly coordinated with cell wall growth and turnover, and many of these control activities depend upon PASTA-domain containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1947cdca723b4b4db31f30655ad3b98
https://pubmed.ncbi.nlm.nih.gov/32469310
https://pubmed.ncbi.nlm.nih.gov/32469310
Autor:
Claire E. Jennings, Jieman Meng, Christopher R. Coxon, Andrew G. Leach, Neshat Rozatian, Emily K. Corlett, Fazila Bunglawala, Sanne J. M. Verhoork, Judith Reeks, Martin E.M. Noble
Publikováno v:
Verhoork, S J M, Jennings, C E, Rozatian, N, Reeks, J, Meng, J, Corlett, E K, Bunglawala, F, Noble, M E M, Leach, A G & Coxon, C R 2019, ' Tuning the Binding Affinity and Selectivity of Perfluoroaryl-Stapled Peptides by Cysteine-Editing ', Chemistry-A European Journal, vol. 25, no. 1, pp. 177-182 . https://doi.org/10.1002/chem.201804163
A growing number of approaches to "staple" α-helical peptides into a bioactive conformation using cysteine cross-linking are emerging. Here, the replacement of l-cysteine with "cysteine analogues" in combinations of different stereochemistry, side c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787734c849bb48224b7905a6825d63ce
https://pubmed.ncbi.nlm.nih.gov/30255959
https://pubmed.ncbi.nlm.nih.gov/30255959
Autor:
Fiona A. Houston, Valerie Wilson, Claire E. Jennings, Catherine J. Owen, Peter Donaldson, Petros Perros, Simon H.S. Pearce
Publikováno v:
Thyroid; 7/01/2004, Vol. 14 Issue 7, p506-509, 4p
Autor:
Ilaria Gionfriddo, Lorenzo Brunetti, Federica Mezzasoma, Francesca Milano, Valeria Cardinali, Roberta Ranieri, Alessandra Venanzi, Sara Pierangeli, Calogero Vetro, Giulio Spinozzi, Erica Dorillo, Hsin Chieh Wu, Caroline Berthier, Raffaella Ciurnelli, Melanie J. Griffin, Claire E. Jennings, Enrico Tiacci, Paolo Sportoletti, Franca Falzetti, Hugues de Thé, Gareth J. Veal, Maria Paola Martelli, Brunangelo Falini
Publikováno v:
Leukemia
Acute myeloid leukemia (AML) with mutated NPM1 accounts for one-third of newly diagnosed AML. Despite recent advances, treatment of relapsed/refractory NPM1-mutated AML remains challenging, with the majority of patients eventually dying due to diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fec530b1ecbab18927d2e38c0786cff